tiago.silva | I3Bs - 3B's Research Group in Biomaterials, Biodegradables and Biomimetics

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Papers in Scientific Journals (85)

Rocha M. S., Carvalho A. C., Marques C. F., Carneiro F., Sousa R. O., Martins E., Tassara E., Reis R. L., and Silva T. H., "Unraveling the Potential of Chondrosia reniformis Collagen for Tissue Engineering Scaffolds, with Particular Insights into Chondrogenic Differentiation", Biomacromolecules, doi:10.1021/acs.biomac.4c01793, 2026.

Rocha M. S., Marques C. F., Pina S., Oliveira J. M., Reis R. L., and Silva T. H., "3D-Printed Cell-Instructive Scaffolds Based on Chondrosia reniformis Collagen and Sr-Doped Calcium Phosphates for Bone Tissue Engineering", ACS Biomaterials Science & Engineering, doi:10.1021/acsbiomaterials.4c01926, 2025.

Almeida M., Silva T. H., Solstad R. G., Lillebo A. I., Calado R., and Vieira H., "How Significant Are Marine Invertebrate Collagens? Exploring Trends in Research and Innovation", Marine Drugs, vol. 23, issue 1, pp. 2, doi:10.3390/md23010002, 2024.

Rocha M. S., Marques C. F., Carvalho A. C., Martins E., Ereskovsky A., Reis R. L., and Silva T. H., "The Characterization and Cytotoxic Evaluation of Chondrosia reniformis Collagen Isolated from Different Body Parts (Ectosome and Choanosome) Envisaging the Development of Biomaterials", Marine Drugs, 2, vol. 22, issue 55, doi:10.3390/md22020055, 2024.

Gomes J. M., Marques C. F., Rodrigues, L.C., Silva T. H., Silva S. S., and Reis R. L., "3D bioactive ionic liquid-based architectures: An anti-inflammatory approach for early-stage osteoarthritis", Acta Biomaterialia , vol. 173, pp. 298-313, doi:https://doi.org/10.1016/j.actbio.2023.11.014, 2024.

Carvalho D. N., Dani S., Sotelo C. G., Perez-Martin R. I., Reis R. L., Silva T. H., and Gelinsky M., "Assessing non-synthetic crosslinkers in biomaterial inks based on polymers of marine origin to increase the shape fidelity in 3D extrusion printing", Biomedical Materials, vol. 18, issue 5, pp. 055017, doi:10.1088/1748-605X/acecec, 2023.

Amorim S., Dudik O., Soares da Costa D., Reis R. L., Silva T. H., and Pires R. A., "Fucoidan-Coated Silica Nanoparticles Promote the Differentiation of Human Mesenchymal Stem Cells into the Osteogenic Lineage", ACS Biomaterials Science & Engineering, vol. 9, issue 8, pp. 4442-5097, doi:10.1021/acsbiomaterials.3c00265, 2023.

Reys L. L., Silva S. S., Costa D., Soares da Costa D., Rodrigues, L.C., Reis R. L., and Silva T. H., "Building Fucoidan/Agarose-Based Hydrogels as a Platform for the Development of Therapeutic Approaches against Diabetes", Molecules, vol. 28, pp. 4523, doi:https://doi.org/10.3390/ molecules28114523, 2023.

Wang L., Oliveira C., Li Q., Ferreira A. S., Nunes C., Coimbra M. A., Reis R. L., Martins A., Wang C., Silva T. H., and Feng X., "Fucoidan from Fucus vesiculosus Inhibits Inflammatory Response, Both In Vitro and In Vivo", Marine Drugs, vol. 21, issue 5, pp. 302, doi:10.3390/md21050302, 2023.

Escobar A., Carvalho M. R., Silva T. H., Reis R. L., and Oliveira J. M., "Longitudinally aligned inner-patterned silk fibroin conduits for peripheral nerve regeneration", In vitro models, pp. 1-11, doi:10.1007/s44164-023-00050-3, 2023.

Rodrigues C. V., Sousa R. O., Carvalho A. C., Alves A. L., Marques C. F., Cerqueira M. T., Reis R. L., and Silva T. H., "Potential of Atlantic Codfish (Gadus morhua) Skin Collagen for Skincare Biomaterials", Molecules, vol. 28, issue 8, pp. 3394, doi:https://doi.org/10.3390/molecules28083394, 2023.

Machado I., Marques C. F., Martins E., Alves A. L., Reis R. L., and Silva T. H., "Marine Gelatin-Methacryloyl-Based Hydrogels as Cell Templates for Cartilage Tissue Engineering", Polymers, vol. 15, issue 7, pp. 1674, doi:https://doi.org/10.3390/polym15071674, 2023.

Carvalho D. N., Lobo F. C. M., Rodrigues L. C., Fernandes E. M., Williams D. S., Mearns Spragg A., Sotelo C. G., Perez-Martin R. I., Reis R. L., Gelinsky M., and Silva T. H., "Advanced Polymeric Membranes as Biomaterials Based on Marine Sources Envisaging the Regeneration of Human Tissues", Gels, vol. 9, issue 3, pp. 247, doi:https://doi.org/10.3390/gels9030247, 2023.

Almeida M. A., Fernandes E. M., Marques C. F., Lobo F. C. M., Sousa R. O., Reis R. L., and Silva T. H., "Structure and Composition of the Cuticle of the Goose Barnacle Pollicipes pollicipes: A Flexible Composite Biomaterial", Marine Drugs, vol. 21, issue 2, pp. 96, doi:10.3390/md21020096, 2023.

Fernandes E. M., Lobo F. C. M., Faria S. I., Gomes L. C., Silva T. H., Mergulhão F. J. M., and Reis R. L., "Development of Cork Biocomposites Enriched with Chitosan Targeting Antibacterial and Antifouling Properties", Molecules, vol. 28, issue 3, pp. 990, doi:10.3390/molecules28030990, 2023.

Martins E., Reis R. L., and Silva T. H., "In Vivo Skin Hydrating Efficacy of Fish Collagen from Greenland Halibut as a High-Value Active Ingredient for Cosmetic Applications", Marine Drugs, vol. 21, pp. 57, doi:10.3390/md21020057, 2023.

Alves A. L., Carvalho A. C., Machado I., Diogo G. S., Fernandes E. M., Castro V. I. B., Pires R. A., Vázquez J. A., Perez-Martin R. I., Alaminos M., Reis R. L., and Silva T. H., "Cell-Laden Marine Gelatin Methacryloyl Hydrogels Enriched with Ascorbic Acid for Corneal Stroma Regeneration", Bioengineering, vol. 10, issue 1, pp. 62, doi:https://doi.org/10.3390/bioengineering10010062, 2023.

Ferreira A. S., Pereira L., Canfora F., Silva T. H., Coimbra M. A., and Nunes C., "Stabilization of Natural Pigments in Ethanolic Solutions for Food Applications: The Case Study of Chlorella vulgaris", Molecules, vol. 28, issue 1, pp. 408, doi:https://doi.org/10.3390/molecules28010408, 2023.

Correia C., Soares da Costa D., Inácio A. R., Vale A. C., Peixoto D., Silva T. H., Reis R. L., Pashkuleva I., and Alves N. M., "Adhesive and antibacterial films based on marine-derived fucoidan and chitosan", Acs Sustainable Chemistry & Engineering, vol. 10, issue 50, pp. 16770 - 16779, doi:10.1021/acssuschemeng.2c05144, 2022.

Martins E. G., Diogo G. S., Pires R. A., Reis R. L., and Silva T. H., "3D Biocomposites Comprising Marine Collagen and Silica-Based Materials Inspired on the Composition of Marine Sponge Skeletons Envisaging Bone Tissue Regeneration", Marine Drugs, vol. 20, issue 11, pp. 718, doi:10.3390/md20110718, 2022.

Escobar A., Carvalho M. R., Maia F. R., Reis R. L., Silva T. H., and Oliveira J. M., "Glial Cell Line-Derived Neurotrophic Factor-Loaded CMCht/PAMAM Dendrimer Nanoparticles for Peripheral Nerve Repair", Pharmaceutics, vol. 14, issue 11, doi:10.3390/pharmaceutics14112408, 2022.

Martins E., Fernandes R., Alves A. L., Sousa R. O., Reis R. L., and Silva T. H., "Skin Byproducts of Reinhardtius hippoglossoides (Greenland Halibut) as Ecosustainable Source of Marine Collagen", Applied Sciences, vol. 12, pp. 11282, doi:10.3390/app122111282, 2022.

Freitas-Ribeiro S., Diogo G. S., Oliveira C., Martins A., Silva T. H., Jarnalo M., Horta R., Reis R. L., and Pirraco R. P., "Growth Factor-Free Vascularization of Marine-Origin Collagen Sponges Using Cryopreserved Stromal Vascular Fractions from Human Adipose Tissue", Marine Drugs, vol. 20, issue 10, pp. 623, doi:10.3390/md20100623, 2022.

Reys L. L., Silva S. S., Soares da Costa D., Reis R. L., and Silva T. H., "Fucoidan-based hydrogels particles as versatile carriers for diabetes treatment strategies", Journal of Biomaterials Science, Polymer Edition , vol. 33, issue 15, pp. 1339-1954, doi:https://doi.org/10.1080/09205063.2022.2088533, 2022.

Monteiro N. O., Oliveira C., Silva T. H., Martins A., Fangueiro J. F., Reis R. L., and Neves N. M., "Biomimetic Surface Topography from the Rubus fruticosus Leaf as a Guidance of Angiogenesis in Tissue Engineering Applications", ACS Biomaterials Science & Engineering, vol. 8, doi:10.1021/acsbiomaterials.2c00264, 2022.

Correia C., Sousa R. O., Vale A. C., Peixoto D., Silva T. H., Reis R. L., Pashkuleva I., and Alves N. M., "Adhesive and biodegradable membranes made of sustainable catechol-functionalized marine collagen and chitosan", Colloids And Surfaces B-biointerfaces, vol. 213, pp. 112409, doi:10.1016/j.colsurfb.2022.112409, 2022.

Carvalho D. N., Gonçalves C., Oliveira J. M., Williams D. S., Mearns Spragg A., Reis R. L., and Silva T. H., "A Design of Experiments (DoE) Approach to Optimize Cryogel Manufacturing for Tissue Engineering Applications", Polymers, vol. 14, pp. 2026-2046, doi:10.3390/polym14102026, 2022.

Carvalho D. N., Williams D. S., Sotelo C. G., Pérez-Marin R. I., Mearns Spragg A., Reis R. L., and Silva T. H., "Marine origin biomaterials using a compressive and absorption methodology as cell-laden hydrogel envisaging cartilage tissue engineering", Biomaterials Advances, doi:10.1016/j.bioadv.2022.212843, 2022.

Alves A. L., Fraguas F. J., Carvalho A. C., Valcarcel J., Pérez-Martín R. I., Reis R. L., Vázquez J. A., and Silva T. H., "Characterization of codfish gelatin: A comparative study of fresh and salted skins and different extraction methods", Food Hydrocolloids, vol. 124, issue PA, doi:10.1016/J.FOODHYD.2021.107238, 2022.

Rahman A., and Silva T. H., "Collagens from Marine Organisms towards Biomedical Applications", Marine Drugs, vol. 20, issue 3, pp. 170, doi:10.3390/md20030170, 2022.

Diogo G. S., Marques C. F., Freitas-Ribeiro S., Sotelo C. G., Pérez-Marin R. I., Pirraco R. P., Reis R. L., and Silva T. H., "Mineralized collagen as a bioactive ink to support encapsulation of human adipose stem cells: A step towards the future of bone regeneration", Biomaterials Advances, doi:10.1016/j.msec.2021.112600, 2022.

Alves A. L., Costa-Gouveia J., Vieira de Castro J., Sotelo C. G., Vázquez J. A., Pérez Martín R. I., Torrado E., Neves N. M., Reis R. L., Castro A. G., and Silva T. H., "Study of the immunologic response of marine-derived collagen and gelatin extracts for tissue engineering applications", Acta Biomaterialia, vol. 141, pp. 123-131, doi:10.1016/j.actbio.2022.01.009, 2022.

Carvalho D. N., Gonçalves C., Oliveira J. M., Willliams D., Mearns Spragg A., Reis R. L., and Silva T. H., "Innovative methodology for marine collagen-chitosan-fucoidan hydrogels production, tailoring rheological properties towards biomedical application", Green Chemistry, pp. 1-14, doi:10.1039/D1GC02223G, 2021.

Reys L. L., Silva S. S., Oliveira C., Neves N. M., Martins A., Reis R. L., and Silva T. H., "Angiogenic potential of airbrushed fucoidan/polycaprolactone nanofibrous meshes", International Journal Of Biological Macromolecules, vol. 183, pp. 695-706, doi:10.1016/j.ijbiomac.2021.04.166, 2021.

Reys L. L., Vaithilingam V., Sthijns M. M. J. P. E., Soares E., Rademakers T., de Vries R., Mohammed S. M., de Bont D., Jetten M., Hermanns C., Filho O. P. S., Stell A., Mourad N. I., Gianello P., Lapointe V. L. S., Silva S. S., Reis R. L., Silva T. H., and van Apeldoorn A. A., "Fucoidan hydrogels significantly alleviate oxidative stress and enhance the endocrine function of encapsulated beta cells", Advanced Functional Materials, vol. 31, pp. 2011205, doi:10.1002/adfm.202011205, 2021.

Frazão L. P., Fernandes A. M., Oliveira C., Martins A., Silva T. H., Vieira de Castro J., Nogueira-Silva C., and Neves N. M., "A new vascular graft using the decellularized human chorion membrane", ACS Biomaterials Science & Engineering, vol. 7, issue 7, pp. 3423–3433, doi:10.1021/acsbiomaterials.1c00293, 2021.

Dudik O., Amorim S., Xavier J. R., Rapp H. T., Silva T. H., Pires R. A., and Reis R. L., "Bioactivity of Biosilica Obtained From North Atlantic Deep-Sea Sponges", Frontiers in Marine Science, vol. 8, pp. 637810, doi:10.3389/fmars.2021.637810, 2021.

Oliveira C., Gonçalves C. S., Martins E. P., Neves N. M., Reis R. L., Costa B. M., Silva T. H., and Martins A., "Fucoidan/chitosan nanoparticles functionalized with anti-ErbB-2 target breast cancer cells and impair tumor growth in vivo", International Journal of Pharmaceutics, vol. 600, pp. 120548, doi:10.1016/j.ijpharm.2021.120548, 2021.

Backes E. H., Fernandes E. M., Diogo G. S., Marques C. F., Silva T. H., Costa L. C., Passador F. R., Reis R. L., and Pessan L. A., "Engineering 3D printed bioactive composite scaffolds based on the combination of aliphatic polyester and calcium phosphates for bone tissue regeneration", Materials Science & Engineering C, vol. 122, pp. 111928, doi:10.1016/j.msec.2021.111928, 2021.

Martins E., Rapp T. H., Xavier J. R., Diogo G. S., Reis R. L., and Silva T. H., "Macro and Microstructural Characteristics of North Atlantic Deep-Sea Sponges as Bioinspired Models for Tissue Engineering Scaffolding", Frontiers in Marine Science, vol. 15, doi:10.3389/fmars.2020.613647, 2021.

Diogo G. S., Carneiro F., Freitas-Ribeiro S., Sotelo C. G., Pérez Martín R. I., Pirraco R. P., Reis R. L., and Silva T. H., "Prionace glauca skin collagen bioengineered constructs as a promising approach to trigger cartilage regeneration", Materials Science and Engineering:C, doi:10.1016/j.msec.2020.111587, 2021.

Gokalp M., Kooistra T., Rocha M. S., Silva T. H., Osinga R., Murk A., and Wijgerde T., "The Effect of Depth on the Morphology, Bacterial Clearance, and Respiration of the Mediterranean Sponge Chondrosia reniformis (Nardo, 1847)", Marine Drugs, vol. 18, issue 7, pp. 358, doi:10.3390/md18070358, 2020.

Carvalho D. N., López-Cebral R., Sousa R. O., Alves A. L., Silva S. S., Oliveira J. M., Reys L. L., Reis R. L., and Silva T. H., "Marine collagen-chitosan-fucoidan cryogels as cell-laden biocomposites envisaging tissue engineering", Biomedical Materials, vol. 15, issue 5, pp. 055030, doi:10.1088/1748-605X/ab9f04, 2020.

Diogo G. S., Marques C. F., Sotelo C. G., Pérez-Marin R. I., Pirraco R. P., Reis R. L., and Silva T. H., "Cell-Laden Biomimetially Mineralized Shark-Skin-Collagen-Based 3D Printed Hydrogels for the Engineering of Hard Tissues ", ACS Biomaterials Science & Engineering, vol. 6, issue 6, pp. 3664–3672, doi:10.1021/acsbiomaterials.0c00436, 2020.

Casanova M. R., Oliveira C., Fernandes E. M., Reis R. L., Silva T. H., Martins A., and Neves N. M., "Spatial immobilization of endogenous growth factors to control vascularization in bone tissue engineering", Biomaterials Science, vol. 8, issue 9, pp. 2577-2589, doi:10.1039/D0BM00087F, 2020.

Sousa R. O., Martins E., Carvalho D. N., Alves A. L., Oliveira C., Duarte A. R. C., Silva T. H., and Reis R. L., "Collagen from Atlantic cod (Gadus morhua) skins extracted using CO2 acidified water with potential application in healthcare", Journal Of Polymer Research, vol. 27, issue 3, doi:10.1007/s10965-020-02048-x, 2020.

Seixas M. J., Martins E., Reis R. L., and Silva T. H., "Extraction and Characterization of Collagen from Elasmobranch Byproducts for Potential Biomaterial Use", Marine Drugs, vol. 18, issue 617, doi:10.3390/md18120617, 2020.

Sousa R. O., Alves A. L., Carvalho D. N., Martins E., Oliveira C., Silva T. H., and Reis R. L., "Acid and enzymatic extraction of collagen from Atlantic cod (Gadus Morhua) swim bladders envisaging health-related applications", Journal of Biomaterials Science, Polymer Edition, doi:10.1080/09205063.2019.1669313, 2019.

Matias R. S., Gregory S., Ceia F. R., Baeta A., Seco J., Rocha M. S., Fernandes E. M., Reis R. L., Silva T. H., Pereira E., Piatkowski U., Ramos J. A., and Xavier J. C., "Show your beaks and we tell you what you eat: Different ecology in sympatric Antarctic benthic octopods under a climate change context", Marine Environmental Research, vol. 150, pp. 104757, doi:10.1016/j.marenvres.2019.104757, 2019.

Oliveira C., Granja S., Neves N. M., Reis R. L., Baltazar F., Silva T. H., and Martins A., "Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo", Carbohydrate Polymers, vol. 223, doi:10.1016/j.carbpol.2019.115034, 2019.

Shen Q., Ou A., Liu S., Elango J., Wang S., Silva T. H., Wu W., Robinson J., and Bao B., "Effects of ion concentrations on the hydroxyl radical scavenging rate and reducing power of fish collagen peptides", Journal Of Food Biochemistry, vol. 43, issue 4, pp. e12789, doi:10.1111/jfbc.12789, 2019.

Carvalho A. M., Marques A. P., Silva T. H., and Reis R. L., "Evaluation of the Potential of Collagen from Codfish Skin as a Biomaterial for Biomedical Applications", Marine Drugs, vol. 16, issue 12, pp. 495-509, doi:10.3390/md16120495, 2018.

Oliveira C., Neves N. M., Reis R. L., Silva T. H., and Martins A., "Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells", Nanomedicine, doi:10.2217/nnm-2018-0004, 2018.

Diogo G. S., Senra E. L., Pirraco R. P., Canadas R. F., Fernandes E. M., Serra J., Pérez-Martín R. I., Sotelo C. G., Marques A. P., González P., Moreira-Silva J., Silva T. H., and Reis R. L., "Marine collagen/apatite composite scaffolds envisaging hard tissue applications", Marine Drugs, vol. 16, issue 8, pp. 269, doi:10.3390/md16080269, 2018.

Dudik O., Leonor I. B., Xavier J. R., Rapp H. T., Pires R. A., Silva T. H., and Reis R. L., "Sponge-derived silica for tissue regeneration: Bioceramics of deep-sea sponge", Materials Today, vol. 21, issue 5, pp. 577-578, doi:10.1016/j.mattod.2018.03.025, 2018.

Ballarin L., Rinkevich B., Bartscherer K., Burzynski A., Cambier S., Cammarata M., Domart-Coulon I., Drobne D., Encinas J., Frank U., Geneviere A. - M., Hobmayer B., Löhelaid H., Lyons D., Martinez P., Oliveri P., Peric L., Piraino S., Ramšak A., Rakers S.,, "Maristem—Stem Cells of Marine/Aquatic Invertebrates: From Basic Research to Innovative Applications", Sustainability, vol. 10, pp. 526, doi:10.3390/su10020526, 2018.

López-Cebral R., Peng G., Reys L. L., Silva S. S., Oliveira J. M., Chen J., Silva T. H., and Reis R. L., "Dual delivery of hydrophilic and hydrophobic drugs from chitosan/ diatomaceous earth composite membranes", Journal of Materials Science: Materials in Medicine, vol. 29, issue 3, pp. 21-33, doi:10.1007/s10856-018-6025-9, 2018.

Fassini D., Duarte A. R. C., Reis R. L., and Silva T. H., "Bioinspiring Chondrosia reniformis (Nardo, 1847) Collagen-Based Hydrogel: A New Extraction Method to Obtain a Sticky and Self-Healing Collagenous Material", Marine Drugs, vol. 15, issue 12, pp. 380-397, doi:10.3390/md15120380, 2017.

Alves A. L., Marques A. L., Martins E., Silva T. H., and Reis R. L., "Cosmetic Potential of Marine Fish Skin Collagen", Cosmetics, 39, vol. 4, issue 4, doi:10.3390/cosmetics4040039, 2017.

Reys L. L., Silva S. S., Pirraco R. P., Marques A. P., Mano J. F., Silva T. H., and Reis R. L., "Influence of freezing temperature and deacetylation degree on the performance of freeze-dried chitosan scaffolds towards cartilage tissue engineering", European Polymer Journal, vol. 95, issue C, pp. 232-240, doi:10.1016/j.eurpolymj.2017.08.017, 2017.

Oliveira C., Ferreira A. S., Novoa-Carballal R., Nunes C., Pashkuleva I., Neves N. M., Coimbra M. A., Reis R. L., Martins A., and Silva T. H., "The Key Role of Sulfation and Branching on Fucoidan Antitumor Activity", Macromolecular Bioscience, vol. 17, issue 5, pp. 1600340, doi:10.1002/mabi.201600340, 2017.

Coelho R. C. G., Marques A. L. P., Oliveira S. M., Diogo G. S., Pirraco R. P., Moreira-Silva J., Xavier J. C., Reis R. L., Silva T. H., and Mano J. F., "Extraction and characterization of collagen from Antarctic and Sub-Antarctic squid and its potential application in hybrid scaffolds for tissue engineering", Materials Science & Engineering C-materials For Biological Applications, vol. 78, doi:10.1016/j.msec.2017.04.122, 2017.

Novoa-Carballal R., Pérez-Martín, R.; Blanco S. M.;, Nunes C., Coimbra M. A., Silva T. H., Reis R. L., and José V. A., "By-products of Scyliorhinus canicula, Prionace glauca and Raja clavata: A valuable source of predominantly 6S sulfated chondroitin sulfate", Carbohydrate Polymers, vol. 157, pp. 31-38, doi:10.1016/j.carbpol.2016.09.050, 2017.

Carvalho C. R., López-Cebral R., Silva-Correia J., Silva J. M., Mano J. F., Silva T. H., Freier T., Reis R. L., and Oliveira J. M., "Investigation of Cell Adhesion in Chitosan Membranes for Peripheral Nerve Regeneration", Materials Science & Engineering C-materials For Biological Applications, vol. 71, pp. 1122-1134, doi:10.1016/j.msec.2016.11.100, 2017.

Barros, A. A., Aroso I. M., Silva T. H., Mano J. F., Duarte A. R. C., and Reis R. L., "In vitro bioactivity studies of ceramic structures isolated from marine sponges", Biomedical Materials, issue 11, pp. 045004, doi:10.1088/1748-6041/11/4/045004, 2016.

Raftery R. M., Woods B., Marques A. L. P., Moreira-Silva J., Silva T. H., Cryan S. - A., Reis R. L., and O'Brien F. J., "Multifunctional Biomaterials from the Sea: Assessing the effects of Chitosan incorporation into Collagen Scaffolds on Mechanical and Biological Functionality", Acta Biomaterialia, vol. 43, pp. 160-169, doi:10.1016/j.actbio.2016.07.009, 2016.

Silva J. C., Barros, A. A., Aroso I. M., Fassini D., Silva T. H., Reis R. L., and Duarte A. R. C., "Extraction of Collagen/Gelatin from the Marine Demosponge Chondrosia reniformis (Nardo, 1847) using Water Acidified with Carbon Dioxide – Process Optimization", Industrial & Engineering Chemistry Research , doi:10.1021/acs.iecr.6b00523, 2016.

Reys L. L., Silva S. S., Soares da Costa D., Oliveira N. M., Mano J. F., Reis R. L., and Silva T. H., "Fucoidan hydrogels photo-cross-linked with visible radiation as matrices for cell culture", ACS Biomaterials Science & Engineering, vol. 2, issue 7, pp. 1151–1161, doi:10.1021/acsbiomaterials.6b00180, 2016.

Pereira D. R., López-Cebral R., Silva-Correia J., Pereira H., Espregueira-Mendes J., Silva T. H., Reis R. L., and Oliveira J. M., "Hyaluronic acid, stem cells and PRP/growth factors in the treatment of osteochondral lesions/Ácido hialurónico, células madre y factores de crecimiento/PRP en el tratamiento de lesiones osteocondrales.", Trauma (Mapfre Foundation Journal), vol. In press, 2015.

Barros, A. A., Aroso I. M., Silva T. H., Mano J. F., Duarte A. R. C., and Reis R. L., "Water and Carbon Dioxide:Green Solvents for the extraction of Collagen/Gelatin from Marine Sponges", ACS Sustainable Chemistry & Engineering, doi:10.1021/sc500621z, 2014.

Barros, A. A., Aroso I. M., Silva T. H., Mano J. F., Duarte A. R. C., and Reis R. L., "Surface modification of silica-based marine sponge bioceramics induce hydroxyapatite formation", Cryst. Growth Des, doi:10.1021/cg500654u, 2014.

Zhang H., Shahbazi M. - A., Mäkilä E. M., Silva T. H., Reis R. L., Salonen J. J., Hirvonen J. T., and Santos H. A., "Diatom silica microparticles for sustained release and permeation enhancement following oral delivery of prednisone and mesalamine", Biomaterials, vol. 34, issue 36, pp. 9210 - 9219, doi:10.1016/j.biomaterials.2013.08.035, 2013.

Silva S. P., Moreira-Silva J., Silva T. H., Perez-Martin R. I., Sotelo C. G., Mano J. F., Duarte A. R. C., and Reis R. L., "Porous hydrogels from shark skin collagen crosslinked under dense carbon dioxide atmosphere", Macromolecular Bioscience, vol. 13, issue 11, pp. 1621-1631, 2013.

Oliveira S. M., Silva T. H., Reis R. L., and Mano J. F., "Nanocoatings containing sulfated polysaccharides prepared by Layer-by-Layer as models to study cell-materials interactions", Journal of Materials Chemistry B, vol. 1, issue 35, pp. 4406-4418, doi:10.1039/C3TB20624F, 2013.

Reys L. L., Silva S. S., Oliveira J. M., Caridade S. G., Mano J. F., Silva T. H., and Reis R. L., "Revealing the potential of squid chitosan-based structures for biomedical applications", Biomedical Materials, vol. 8, issue 4, doi: doi:10.1088/1748-6041/8/4/045002, 2013.

Silva-Correia J., Zavan B., Vindigni V., Silva T. H., Oliveira J. M., Abatangelo G., and Reis R. L., "Biocompatibility Evaluation of Ionic- and Photo-Crosslinked Methacrylated Gellan Gum Hydrogels: In Vitro and In Vivo Study", Advanced Healthcare Materials, vol. 2, issue 4, pp. 568-575, 2013.

Duarte A. R. C., Santo V. E., Alves A., Silva S. S., Moreira-Silva J., Silva T. H., Marques A. P., Gomes M. E., Sousa R. A., Mano J. F., and Reis R. L., "Unleashing the potential of supercritical fluids for polymer processing in tissue engineering and regenerative medicine", The Journal of Supercritical Fluids, vol. 79, pp. 177-185, doi:10.1016/j.supflu.2013.01.004, 2013.

Silva S. S., Santos T. C., Cerqueira M. T., Marques A. P., Reys L. L., Silva T. H., Caridade S. G., Mano J. F., and Reis R. L., "The use of ionic liquids in the processing of chitosan/silk hydrogels for biomedical applications", Green Chemistry , vol. 14, pp. 1463-1470, doi:10.1039/C2GC16535J, 2012.

Oliveira S. M., Silva T. H., Reis R. L., and Mano J. F., "Hierarchical fibrillar scaffolds obtained by non-conventional layer-by-layer electrostatic self-assembly", Advanced Healthcare Materials, doi:10.1002/adhm.201200204 , 2012.

Reys L. L., Silva S. S., Oliveira J. M., Frias A. M., Mano J. F., Silva T. H., and Reis R. L., "Valorization of chitosan from squid pens and further use on the development of scaffolds for biomedicalapplications", The International Journal of Artificial Organs, vol. 34, issue 8, pp. 704, 2012.

Sá Miranda E., Silva T. H., Reis R. L., and Mano J. F., "Nanostructured Natural-based Polyelectrolyte Multilayers to agglomerate Chitosan Particles into scaffolds for Tissue Engineering", Tissue Engineering Part A, vol. 17, issue 21-22, pp. 2663-2674, 2011.

Silva T. H., Mano J. F., and Reis R. L., "Marine polysaccharide multilayers: PH responsive systems for the surface modification of tissue engineering scaffolds", Tissue Engineering Part A, vol. 14, issue 5, pp. 753-753, 2008.

Silva T. H., García-Morales V., Moura C., Manzanares J. A., and Silva F., "Electrochemical Impedance Spectroscopy of Polyelectrolyte Multilayer Modified Gold Electrodes: Influence of Supporting Electrolyte and Temperature", Langmuir, vol. 21, pp. 7461-7467, 2005.

García-Morales V., Silva T. H., Moura C., Manzanares J. A., and Silva F., "Ion transport through polyelectrolyte multilayers under steady state conditions", Journal of Electroanalytical Chemistry, vol. 569, pp. 111-119, 2004.

Silva T. H., Barreira S. V. P., Moura C., and Silva F., "Electrochemical characterization of a self-assembled polyelectrolyte film", Portugaliae Electrochimica Acta, vol. 21, pp. 281-292, 2003.

Review Paper (14)

García-González M., Vidal-Negreira F., González-Cantalapiedra A., Reis R. L., and Silva T. H., "Use of collagen from marine origin for bone tissue regeneration in preclinical in vivo studies: a systematic review and quality evaluation", Biomaterials Advances, vol. 183, pp. 214753, doi:10.1016/j.bioadv.2026.214753, 2026.

Carvalho D. N., Gonçalves C., Sousa R. O., Reis R. L., Oliveira J. M., and Silva T. H., "Extraction and Purification of Biopolymers from Marine Origin Sources Envisaging Their Use for Biotechnological Applications", Marine Biotechnology, pp. 1-41, doi:/10.1007/s10126-024-10361-5, 2024.

Diogo G. S., Pirraco R. P., Reis R. L., and Silva T. H., "From Its Nature to Its Function: Marine-Collagen-Based-Biomaterials for Hard Tissue Applications", Tissue Engineering Part B: Reviews, vol. 30, issue 3, pp. 299–314, doi:doi.org/10.1089/ten.teb.2023.0077, 2023.

Fernandes A. S., Oliveira C., Reis R. L., Martins A., and Silva T. H., "Marine-Inspired Drugs and Biomaterials in the Perspective of Pancreatic Cancer Therapies", Marine Drugs, vol. 20, issue 11, pp. 689, doi:10.3390/md20110689, 2022.

Romano G., Mariana A., Coelho A. V., Cutignano A., Gonçalves L. G., Hansen E., Khnykin D., Mass T., Ramšak A., Rocha M. S., Silva T. H., Sugni M., Ballarin L., and Geneviere A. - M., "Biomaterials and Bioactive Natural Products from Marine Invertebrates: From Basic Research to Innovative Applications", Marine Drugs, vol. 20, issue 4, pp. 219, doi:10.3390/md20040219, 2022.

Gonçalves C., Carvalho D. N., Silva T. H., Reis R. L., and Oliveira J. M., "Engineering of Viscosupplement Biomaterials for Treatment of Osteoarthritis: A Comprehensive Review", Advanced Engineering Materials, vol. 24, issue 8, pp. 2101541 (1 of 16), doi:10.1002/adem.202101541, 2022.

Carvalho D. N., Reis R. L., and Silva T. H., "Marine origin materials on biomaterials and advanced therapies to cartilage tissue engineering and regenerative medicine", Biomaterials science, pp. 1-19, doi:10.1039/D1BM00809A, 2021.

Fassini D., Wilkie I. C., Pozzolini M., Ferrario C., Sugni M., Rocha M. S., Giovine M., Bonasoro F., Silva T. H., and Reis R. L., "Diverse and Productive Source of Biopolymer Inspiration: Marine Collagens", Biomacromolecules, doi:10.1021/acs.biomac.1c00013, 2021.

Oliveira C., Neves N. M., Reis R. L., Martins A., and Silva T. H., "A review on fucoidan antitumor strategies: From a biological active agent to a structural component of fucoidan-based systems", Carbohydrate Polymers, vol. 239, doi:10.1016/j.carbpol.2020.116131, 2020.

Almeida M., Reis R. L., and Silva T. H., "Marine invertebrates are a source of bioadhesives with biomimetic interest", Materials Science & Engineering C, vol. 108, pp. 110467, doi:10.1016/j.msec.2019.110467, 2019.

López-Cebral R., Silva-Correia J., Reis R. L., Silva T. H., and Oliveira J. M., "Peripheral nerve injury: Current challenges, conventional treatment approaches and new trends on biomaterials-based regenerative strategies", ACS Biomaterials Science & Engineering, vol. 3, issue 12, pp. 3098–3122, doi:10.1021/acsbiomaterials.7b00655, 2017.

Shavandi A., Silva T. H., Bekhit A. A., and Bekhit A. E. - D. A., "Keratin: dissolution, extraction and biomedical application", Biomaterials Science, vol. 5, pp. 1699-1735, doi:10.1039/c7bm00411g, 2017.

Silva T. H., Moreira-Silva J., Marques A. L. P., Domingues A., Bayon Y., and Reis R. L., "Marine Origin Collagens and Its Potential Applications", Marine Drugs, vol. 12, issue 12, pp. 5881-5901, doi:10.3390/md12125881, 2014.

Silva T. H., Alves A., Popa E. G., Reys L. L., Gomes M. E., Sousa R. A., Silva S. S., Mano J. F., and Reis R. L., "Marine Algae Sulfated Polysaccharides for Tissue Engineering and Drug Delivery Approaches", BioMatter, vol. 2, issue 4, pp. 278-289, doi:doi.org/10.4161/biom.22947, 2012.

Book Chapter (16)

Rocha M. S., Dudik O., Pires R. A., Silva T. H., and Reis R. L., "Marine Sponge-Derived Biomaterials and Their Biomedical Applications", Marine Sponge Biotechnology and Bioproducts, Eds. Zhang W., and Newman D. J., Springer, Cham, doi:10.1007/978-3-031-95183-1_9, 2025.

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