Project | NORTE45_3Bs :: publications list |
Title | Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo |
Publication Type | Papers in Scientific Journals |
Year of Publication | 2019 |
Authors | Oliveira C., Granja S., Neves N. M., Reis R. L., Baltazar F., Silva T. H., and Martins A. |
Abstract | Fucoidan is a marine-origin sulfated polysaccharide that can show anticancer activity, to which both pro- and anti-angiogenic responses have been reported. Due to this unpredictability, the angiogenic potential of an effective anticancer crude fucoidan (CF), at a concentration of 0.5 mg mL−1, was evaluated. Tube formation assays demonstrated that CF, either administered while endothelial cells seeding or after their adhesion, migration and organization, inhibited or disrupted the formation of tubular-like structures, respectively. Although CF did not significantly reduced vascular endothelial growth factor (VEGF) secretion, it significantly reduced the expression of platelet-derived growth factor (PDGF), compromising the blood vessels maturation. Two chicken embryo chorioallantoic membrane (CAM) assays were performed: one without tumor (CAM I) and the other with an onplanted tumor mass (CAM II); the CF injection reduced the number of blood of vessels and significantly decreased the tumor size, respectively. In vitro and in vivoresults support the effectiveness of fucoidan as a natural antitumor therapeutic agent. |
Journal | Carbohydrate Polymers |
Volume | 223 |
Date Published | 2019-06-28 |
Publisher | Elsevier |
ISSN | 0144-8617 |
DOI | 10.1016/j.carbpol.2019.115034 |
URL | https://www.sciencedirect.com/science/article/pii/S0144861719307015 |
Keywords | Angiogenesis, Anticancer, Fucoidan, Tumor |
Rights | openAccess |
Peer reviewed | yes |
Status | published |