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Papers in Scientific Journals (91)
Correia C.
,
Cruz-Moreira D.
,
Gonçalves F. S.
,
Cardoso V. F.
,
Paiva M. C.
,
Reis R. L.
,
Pashkuleva I.
,
Peixoto D.
, and
Alves N. M.
,
"
Multifunctional Hyaluronic Acid/Graphite Nanoplatelet Hydrogels as Tools for Spinal Cord Regeneration
",
Acs Applied Materials & Interfaces
, vol. 17, issue 51, pp. 69196 - 69208, doi:
10.1021/acsami.5c20777
, 2025.
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Puertas-Segura A.
,
Laganá A.
,
Rathee G.
,
Savage P.
,
Todorova K.
,
Dimitrov P.
,
Pashkuleva I.
,
Reis R. L.
,
Ciardelli G.
, and
Tzanov T.
,
"
Ceragenin nanogel coating prevents biofilms formation on urinary catheters
",
ACS Applied Materials and Interfaces
, vol. 17, issue 31, pp. 44319 - 44332, doi:
10.1021/acsami.5c13979
, 2025.
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Castro V. I. B.
,
Araújo A. R.
,
Reis R. L.
,
Pashkuleva I.
, and
Pires R. A.
,
"
Nanoengineered self-assembling peptides with increased proteolytic stability promote wound healing
",
Acs Applied Materials & Interfaces
, vol. 17, issue 8, pp. 11624 - 11633, doi:
10.1021/acsami.4c18221
, 2025.
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Correia C.
,
Peixoto D.
,
Soares da Costa D.
,
Reis R. L.
,
Pashkuleva I.
, and
Alves N. M.
,
"
Development and in vitro assessment of injectable, adhesive, and self-healing chitosan-based hydrogels for treatment of spinal cord injury
",
Biomaterials Advances
, vol. 167, pp. 214090, doi:
10.1016/j.bioadv.2024.214090
, 2025.
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RepositoriUM
Castro V. I. B.
,
Amorim S.
,
Caballero D.
,
Abreu C. M.
,
Kundu S. C.
,
Reis R. L.
,
Pashkuleva I.
, and
Pires R. A.
,
"
Patterned glycopeptide-based supramolecular hydrogel promotes the alignment and contractility of iPSC-derived cardiomyocytes
",
Biomaterials Advances
, vol. 167, pp. 214091, doi:
10.1016/j.bioadv.2024.214091
, 2025.
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RepositoriUM
Albuquerque A. V.
,
Soares da Costa D.
,
Correia C.
,
Reis R. L.
,
Alves N. M.
,
Costa R. R.
, and
Pashkuleva I.
,
"
Effect of hyaluronan molecular weight on the stability and biofunctionality of microfibers assembled by interfacial polyelectrolyte complexation
",
Acs Applied Materials & Interfaces
, vol. 17, issue 2, pp. 4199 - 4209, doi:
10.1021/acsami.4c18335
, 2025.
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RepositoriUM
Costa R. R.
,
Domínguez-Arca V.
,
Velasco B.
,
Reis R. L.
,
Rodríguez-Cabello J. C.
,
Pashkuleva I.
,
Taboada P.
, and
Prieto G.
,
"
Cholesterol Conjugated Elastin-like Recombinamers: Molecular Dynamics Simulations, Conformational Changes, and Bioactivity
",
Acs Applied Materials & Interfaces
, vol. 16, issue 48, pp. 66327–66340, doi:
10.1021/acsami.4c07285
, 2024.
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RepositoriUM
Gonçalves R. R.
,
Peixoto D.
,
Costa R. R.
,
Franco A. R.
,
Castro V. I. B.
,
Pires R. A.
,
Reis R. L.
,
Pashkuleva I.
,
Maniglio D.
,
Tirella A.
,
Motta A.
, and
Alves N. M.
,
"
Antibacterial properties of photo-crosslinked chitosan/methacrylated hyaluronic acid nanoparticles loaded with bacitracin
",
International Journal of Biological Macromolecules
, vol. 227, pp. 134250, doi:
10.1016/j.ijbiomac.2024.134250
, 2024.
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Castro V. I. B.
,
Gao Y.
,
Brito A.
,
Chen J.
,
Reis R. L.
,
Pashkuleva I.
, and
Pires R. A.
,
"
Cooling rate uncovers epimer-dependent supramolecular organization of carbohydrate amphiphiles
",
Journal Of Materials Chemistry B
, vol. 12, pp. 6996-7000, 2024.
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RepositoriUM
Martins S. A.
,
Costa R. R.
,
Brito A.
,
Reis R. L.
,
Alves N. M.
,
Pashkuleva I.
, and
Soares da Costa D.
,
"
Multifunctional calcium-based nanocarriers for synergistic treatment of triple-negative breast cancer
",
Journal Of Colloid And Interface Science
, vol. 674, pp. 500 - 512, doi:
10.1016/j.jcis.2024.06.159
, 2024.
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RepositoriUM
Fernandes E.
,
Costa R. R.
,
Machado R.
,
Reis R. L.
,
Pashkuleva I.
, and
Lucio M.
,
"
A label-free multitechnique approach to characterize the interaction of bioactive compounds with biomimetic interfaces
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Small Science
, vol. 4, issue 4, pp. 2300271, doi:
10.1002/smsc.202300271
, 2024.
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RepositoriUM
Duarte D.
,
Correia C.
,
Reis R. L.
,
Pashkuleva I.
,
Peixoto D.
, and
Alves N. M.
,
"
Bioadhesive hyaluronic acid-based hydrogels for spinal cord injury
",
Biomacromolecules
, vol. 25, issue 3, pp. 1592-1601, doi:
10.1021/acs.biomac.3c01186
, 2024.
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RepositoriUM
Amaral S.
,
Lozano-Fernández T.
,
Sabin J.
,
Gallego A.
,
da Silva Morais A.
,
Reis R. L.
,
Gonzalez-Fernández A.
,
Pashkuleva I.
, and
Novoa-Carballal R.
,
"
End-on PEGylation of heparin: Effect on anticoagulant activity and complexation with protamine
",
International Journal of Biological Macromolecules
, vol. 249, pp. 125957, doi:
10.1016/j.ijbiomac.2023.125957
, 2023.
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RepositoriUM
Bastos F. R.
,
Soares da Costa D.
,
Reis R. L.
,
Alves N. M.
,
Pashkuleva I.
, and
Costa R. R.
,
"
Layer-by-layer coated calcium carbonate nanoparticles for targeting breast cancer cells
",
Biomaterials Advances
, vol. 153, pp. 213563, doi:
10.1016/j.bioadv.2023.213563
, 2023.
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RepositoriUM
Costa R. R.
,
Caballero D.
,
Soares da Costa D.
,
Rodriguez-Trujillo R.
,
Kundu S. C.
,
Reis R. L.
, and
Pashkuleva I.
,
"
Microfluidic-assisted interfacial complexation of extracellular matrix components to mimic the properties of neural tissues
",
Advanced Materials Technologies
, vol. 8, issue 19, pp. 2300983, doi:
10.1002/admt.202300983
, 2023.
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RepositoriUM
Castro V. I. B.
,
Araújo A. R.
,
Duarte F.
,
Sousa-Franco A.
,
Reis R. L.
,
Pashkuleva I.
, and
Pires R. A.
,
"
Glycopeptide-based supramolecular hydrogels induce differentiation of adipose stem cells into neural lineages
",
Acs Applied Materials & Interfaces
, vol. 15 , issue 25, pp. 29998 - 30007, doi:
10.1021/acsami.3c05309
, 2023.
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RepositoriUM
Martins A. M.
,
Brito A.
,
Barbato M. G.
,
Felici A.
,
Reis R. L.
,
Pires R. A.
,
Pashkuleva I.
, and
Decuzzi P.
,
"
Efficacy of molecular and nano-therapies on brain tumor models in microfluidic devices
",
Biomaterials Advances
, vol. 144, pp. 213227, doi:
10.1016/j.bioadv.2022.213227
, 2023.
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RepositoriUM
Correia C.
,
Soares da Costa D.
,
Inácio A. R.
,
Vale A. C.
,
Peixoto D.
,
Silva T. H.
,
Reis R. L.
,
Pashkuleva I.
, and
Alves N. M.
,
"
Adhesive and antibacterial films based on marine-derived fucoidan and chitosan
",
Acs Sustainable Chemistry & Engineering
, vol. 10, issue 50, pp. 16770 - 16779, doi:
10.1021/acssuschemeng.2c05144
, 2022.
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RepositoriUM
Fontelo R.
,
Soares da Costa D.
,
Gómez-Florit M.
,
Tiainen H.
,
Reis R. L.
,
Novoa-Carballal R.
, and
Pashkuleva I.
,
"
Antibacterial nanopatterned coatings for dental implants
",
Journal Of Materials Chemistry B
, vol. 10, pp. 8710 - 8718, doi:
10.1039/D2TB01352E
, 2022.
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RepositoriUM
Carvalho A. M.
,
Valcarcel J.
,
Soares da Costa D.
,
Gomes M.
,
Vázquez J. A.
,
Reis R. L.
,
Novoa-Carballal R.
, and
Pashkuleva I.
,
"
Hyaluronan brush-like copolymers promote CD44 declustering in breast cancer cells
",
Acs Applied Materials & Interfaces
, vol. 14, issue 37, pp. 41779 - 41789, doi:
10.1021/acsami.2c11864
, 2022.
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RepositoriUM
Fontelo R.
,
Soares da Costa D.
,
Reis R. L.
,
Novoa-Carballal R.
, and
Pashkuleva I.
,
"
Block copolymer nanopatterns affect cell spreading: stem versus cancer bone cells
",
Colloids and Surfaces B: Biointerfaces
, vol. 219, pp. 112774, doi:
10.1016/j.colsurfb.2022.112774
, 2022.
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RepositoriUM
Correia C.
,
Sousa R. O.
,
Vale A. C.
,
Peixoto D.
,
Silva T. H.
,
Reis R. L.
,
Pashkuleva I.
, and
Alves N. M.
,
"
Adhesive and biodegradable membranes made of sustainable catechol-functionalized marine collagen and chitosan
",
Colloids And Surfaces B-biointerfaces
, vol. 213, pp. 112409, doi:
10.1016/j.colsurfb.2022.112409
, 2022.
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Carvalho A. M.
,
Soares da Costa D.
,
Reis R. L.
, and
Pashkuleva I.
,
"
RHAMM expression tunes the response of breast cancer cell lines to hyaluronan
",
Acta Biomaterialia
, vol. 146, pp. 187 - 196, doi:
10.1016/j.actbio.2022.05.013
, 2022.
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Carvalho A. M.
,
Soares da Costa D.
,
Reis R. L.
, and
Pashkuleva I.
,
"
Influence of hyaluronan density on the behavior of breast cancer cells with different CD44 expression
",
Advanced Healthcare Materials
, vol. 11, issue 4, pp. 2101309, doi:
10.1002/adhm.202101309
, 2022.
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RepositoriUM
Fontelo R.
,
Soares da Costa D.
,
Reis R. L.
,
Novoa-Carballal R.
, and
Pashkuleva I.
,
"
Antithrombotic and hemocompatible properties of nanostructured coatings assembled from block copolymers
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Journal of Colloid and Interface Science
, vol. 608, issue part 2, pp. 1608-1618, doi:
10.1016/j.jcis.2021.10.076
, 2022.
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RepositoriUM
Brito A.
,
Dave D.
,
Lampel A.
,
Castro V. I. B.
,
Kroiss D.
,
Reis R. L.
,
Tuttle T.
,
Ulijn R. V.
,
Pires R. A.
, and
Pashkuleva I.
,
"
Expanding the conformational landscape of minimalistic tripeptides by their O‑glycosylation
",
Journal of the American Chemical Society
, vol. 143, issue 47, pp. 19703 - 19710, doi:
10.1021/jacs.1c07592
, 2021.
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RepositoriUM
Amorim S.
,
Soares da Costa D.
,
Mereiter S.
,
Pashkuleva I.
,
Reis C. A.
,
Reis R. L.
, and
Pires R. A.
,
"
Multilayer Platform to Model the Bioactivity of Hyaluronic Acid in Gastric Cancer
",
Materials Science and Engineering C
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10.1016/j.msec.2020.111616
, 2021.
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Domínguez-Arca V.
,
Costa R. R.
,
Carvalho A. M.
,
Taboada P.
,
Reis R. L.
,
Prieto G.
, and
Pashkuleva I.
,
"
Liposomes embedded in layer by layer constructs as simplistic extracellular vesicles transfer model
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Materials Science and Engineering C
, vol. 121, pp. 111813, doi:
10.1016/j.msec.2020.111813
, 2021.
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RepositoriUM
Amorim S.
,
Soares da Costa D.
,
Pashkuleva I.
,
Reis C. A.
,
Reis R. L.
, and
Pires R. A.
,
"
3D hydrogel mimics of the tumor microenvironment: the interplay among hyaluronic acid, stem cells and cancer cells
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Biomaterials Science
, vol. 9, issue 1, pp. 252-260, doi:
10.1039/D0BM00843E
, 2021.
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RepositoriUM
Carvalho A. M.
,
Soares da Costa D.
,
Paulo P. M. R.
,
Reis R. L.
, and
Pashkuleva I.
,
"
Co-localization and crosstalk between CD44 and RHAMM depend on hyaluronan presentation
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Acta Biomaterialia
, vol. 119, pp. 114-124, doi:
10.1016/j.actbio.2020.10.024
, 2021.
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Amorim S.
,
Soares da Costa D.
,
Pashkuleva I.
,
Reis C. A.
,
Reis R. L.
, and
Pires R. A.
,
"
Hyaluronic Acid of Low Molecular Weight Triggers the Invasive “Hummingbird” Phenotype on Gastric Cancer Cells
",
Advanced Biosystems
, pp. 2000122, doi:
10.1002/adbi.202000122
, 2020.
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RepositoriUM
Brito A.
,
Pereira P. M. R.
,
Reis R. L.
,
Ulijn R. V.
,
Lewis J. S.
,
Pires R. A.
, and
Pashkuleva I.
,
"
Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse
",
Nanoscale
, vol. 12, pp. 19088 - 19092, doi:
10.1039/D0NR05008C
, 2020.
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RepositoriUM
Yankova I.
,
Shestakova P.
,
Reis R. L.
,
Pashkuleva I.
, and
Vassileva E.
,
"
Gelatin micro- and nanocapsules obtained via sonochemical method
",
Journal Of Applied Polymer Science
, vol. 137, issue 48, pp. e49584, doi:
10.1002/app.49584
, 2020.
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Fontelo R.
,
Soares da Costa D.
,
Reis R. L.
,
Novoa-Carballal R.
, and
Pashkuleva I.
,
"
Bactericidal nanopatterns generated by block copolymer self-assembly
",
Acta Biomaterialia
, vol. 112, pp. 174-181, doi:
10.1016/j.actbio.2020.06.003
, 2020.
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Brito A.
,
Pereira P. M. R.
,
Soares da Costa D.
,
Reis R. L.
,
Ulijn R. V.
,
Lewis J. S.
,
Pires R. A.
, and
Pashkuleva I.
,
"
Inhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as antagonists of the glucose transporter GLUT1
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Chemical Science
, vol. 11, issue 14, pp. 3737-3744, doi:
10.1039/D0SC00954G
, 2020.
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RepositoriUM
Amorim S.
,
Pashkuleva I.
,
Reis C. A.
,
Reis R. L.
, and
Pires R. A.
,
"
Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44
",
Journal Of Materials Chemistry B
, vol. 17, pp. 3880-3885, doi:
10.1039/d0tb00407c
, 2020.
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Soares da Costa D.
,
Sousa J. C.
,
da Mesquita S.
,
Petkova-Yankova N.
,
Marques F.
,
Reis R. L.
,
Sousa N.
, and
Pashkuleva I.
,
"
Bioorthogonal Labeling Reveals Different Expression of Glycans in Mouse Hippocampal Neuron Cultures during Their Development
",
Molecules
, vol. 25, issue 4, pp. 795, doi:
10.3390/molecules25040795
, 2020.
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Rial R.
,
Costa R. R.
,
Reis R. L.
,
Liu Z.
,
Pashkuleva I.
, and
Ruso J. M.
,
"
Mineralization of layer-by-layer ultrathin films containing microfluidic-produced hydroxyapatite nanorods
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Crystal Growth & Design
, vol. 19, issue 11, pp. 6351 - 6359, doi:
10.1021/acs.cgd.9b00831
, 2019.
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Brito A.
,
Abul-Haija Y. M.
,
Soares da Costa D.
,
Novoa-Carballal R.
,
Reis R. L.
,
Ulijn R. V.
,
Pires R. A.
, and
Pashkuleva I.
,
"
Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles
",
Chemical Science
, vol. 10, pp. 2385 - 2390, doi:
10.1039/c8sc04361b
, 2019.
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Costa R. R.
,
Soares da Costa D.
,
Reis R. L.
, and
Pashkuleva I.
,
"
Bioinspired baroplastic glycosaminoglycan sealants for soft tissues
",
Acta Biomaterialia
, pp. 108 - 117, doi:
10.1016/j.actbio.2019.01.040
, 2019.
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Amorim S.
,
Soares da Costa D.
,
Freitas D.
,
Reis C. A.
,
Reis R. L.
,
Pashkuleva I.
, and
Pires R. A.
,
"
Molecular weight of surface immobilized hyaluronic acid influences CD44-mediated binding of gastric cancer cells
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Scientific Reports
, vol. 8, pp. 16058, doi:
10.1038/s41598-018-34445-0
, 2018.
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Novoa-Carballal R.
,
Carretero A. C.
,
Pacheco R.
,
Reis R. L.
, and
Pashkuleva I.
,
"
Star-like glycosaminoglycans with superior bioactivity assemble with proteins into microfibers
",
Chemistry: A European Journal
, vol. 24, pp. 14341 - 14345, doi:
10.1002/chem.201802243
, 2018.
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Costa R. R.
,
González-Pérez M.
,
Herrero-Gutiérrez M.
,
Pires R. A.
,
Alonso M.
,
Rodríguez-Cabello J. C.
,
Reis R. L.
, and
Pashkuleva I.
,
"
Tuning the stiffness of surfaces by assembling genetically engineered polypeptides with tailored amino acid sequence
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Biomacromolecules
, vol. 19, issue 8, pp. 3401–3411, doi:
10.1021/acs.biomac.8b00723
, 2018.
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Carvalho A. M.
,
Teixeira R.
,
Novoa-Carballal R.
,
Pires R. A.
,
Reis R. L.
, and
Pashkuleva I.
,
"
Redox-responsive micellar nanoparticles from glycosaminoglycans for CD44 targeted drug delivery
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Biomacromolecules
, vol. 19, issue 7, pp. 2991 - 2999, doi:
10.1021/acs.biomac.8b00561
, 2018.
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Ribeiro V. P.
,
Almeida L.
,
Martins A. R.
,
Pashkuleva I.
,
Marques A. P.
,
Ribeiro A. S.
,
Silva C. J.
,
Bonifácio G.
,
Sousa R. A.
,
Oliveira A. L.
, and
Reis R. L.
,
"
Modulating cell adhesion to polybutylene succinate biotextile constructs for tissue engineering applications
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Journal of Tissue Engineering and Regenerative Medicine
, vol. 11, issue 10, doi:
10.1002/term.2189
, 2017.
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Silva C.
,
Carretero A. C.
,
Soares da Costa D.
,
Reis R. L.
,
Novoa-Carballal R.
, and
Pashkuleva I.
,
"
Design of protein delivery systems by mimicking extracellular mechanisms for protection of growth factors
",
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The Key Role of Sulfation and Branching on Fucoidan Antitumor Activity
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Extracellular matrix-inspired assembly of glycosaminoglycan-collagen fibers
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Teixeira R.
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Yang Y.
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Silva C.
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Following the enzymatic digestion of chondroitin sulfate by a simple GPC analysis
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Adhesion of adipose-derived mesenchymal stem cells to glycosaminoglycan surfaces with different protein patterns
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Ribeiro V. P.
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Pires R. A.
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Controlling Cancer Cell Fate Using Localized Biocatalytic Self-Assembly of an Aromatic Carbohydrate Amphiphile
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Tunable nano-carriers from clicked glycosaminoglycan block copolymers
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Erratum: New biotextiles for tissue engineering: Development, characterization and in vitro cellular viability
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New biotextiles for tissue engineering: Development, characterization and in vitro cellular viability
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Altgärde N.
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Probing the biofunctionality of biotinylated hyaluronan and chondroitin sulfate by hyaluronidase degradation and aggrecan interaction
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Amorim S.
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Interactions between exogenous FGF-2 and sulfonic groups: in situ characterization and impact on the morphology of human adipose-derived stem cells
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Francesko A.
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Functional biopolymer-based matrices for modulation of chronic wound enzyme activities
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Francesko A.
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GAGs-thiolated chitosan assemblies for chronic wounds treatment: control of enzyme activity and cell attachment
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Sulphonic groups induce formation of filopodia in mesenchymal stem cells
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Synthesis and functionalization ofsuperparamagnetic polycaprolactone microparticles for the selective isolation of subpopulations ofhuman adipose-derived stem cells
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Highly porous and interconnected starch-based scaffolds: production, characterization and surface modification
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Pashkuleva I.
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Surface Modification of Starch Based Biomaterials by Oxygen Plasma or UV-Irradiation
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Surface phosphorylation of chitosan significantly improves Osteoblast cells viability, attachment and proliferation
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A new route to produce starch-based fiber mesh scaffolds by wet spinning and subsequent surface modification as a way to improve cell attachment and proliferation
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Martins A.
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Surface Modification of Electrospun Polycaprolactone Nanofiber Meshes by Plasma Treatment to Enhance Biological Performance
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Santos M. I.
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Pashkuleva I.
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Surface Structural Investigation of Starch-Based Biomaterials
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Coutinho D. F.
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Plasma Surface Modification of Chitosan Membranes: Characterization and Preliminary Cell Response Studies
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Lopez-Perez P. M.
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Effect of chitosan membrane surface modification via plasma induced polymerization on the adhesion of osteoblast-like cells
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Correlo V. M.
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Water Absorption and Degradation Characteristics of Chitosan-based polyesters and Hydroxyapatite Composites
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Pashkuleva I.
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Surface modification of starch based blends using potassium permanganate-nitric acid system and its effect on the adhesion and proliferation of osteoblast-like cells
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Dryanska V.
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A convenient synthesis of threo-4-amino-3, 4-diphenylbutanoic acid and its derivatives
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Ivanova D.
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Synthesis and stereochemistry of 1,2,4,5-tetraarylimidazolidines
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A simple and efficient synthesis of g-aminobutyric acid (GABA) derivatives
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Review Paper (10)
Castro V. I. B.
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Bioinspired helical systems with defined chirality assembled from discrete peptide and glycan amphiphiles
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Fontelo R.
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Correia C.
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Adhesive and self-healing materials for central nervous system repair
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Carvalho A. M.
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Hyaluronan receptors as mediators and modulators of the tumor microenvironmen
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Costa R. R.
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Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices
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Brito A.
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Carbohydrate amphiphiles for supramolecular biomaterials: Design, self-assembly, and applications
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Sulfation of Glycosaminoglycans and its Implications in Human Health and Disorders
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Controlling Cell Behavior Through the Design of Polymer Surfaces
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