Papers in Scientific Journals (28)
Vilela C. A., Correia C., da Silva Morais A., Santos T. C., Gertrudes A. C., Moreira E. S., Frias A. M., Learmonth D. A., Oliveira P., Oliveira J. M., Sousa R. A., Espregueira-Mendes J., and Reis R. L.,
"In Vitro and in Vivo Performance of MethacrylatedGellan Gum Hydrogel Formulations for Cartilage Repair",
Journal of Biomedical Materials Research Part A, vol. 106A, issue 7, pp. 1987-1996, doi:
10.1002/jbm.a.36406, 2018.
da Silva L. P., Cerqueira M. T., Rodrigues D. B., Pirraco R. P., Santos T. C., Reis R. L., Correlo V. M., and Marques A. P.,
"Stem Cell-Containing Hyaluronic Acid-Based Spongy Hydrogels for Integrated Diabetic Wound Healing",
JID, vol. 137, issue 7, pp. 1541-1551, doi:
10.1016/j.jid.2017.02.976, 2017.
Costa M., Cerqueira M. T., Santos T. C., Sampaio-Marques B., Ludovico P., Marques A. P., Pirraco R. P., and Reis R. L.,
"Cell sheet engineering using the stromal vascular fraction of adipose tissue as a vascularization strategy",
Acta Biomaterialia, vol. 55, pp. 131-143, doi:
10.1016/j.actbio.2017.03.034, 2017.
da Silva L. P., Oliveira S., Pirraco R. P., Santos T. C., Reis R. L., Marques A. P., and Correlo V. M.,
"Eumelanin-releasing spongy-like hydrogels for skin re-epithelialization purposes.",
Biomedical Materials, vol. 12, issue 2, doi:
10.1088/1748-605X/aa5f79, 2017.
da Silva L. P., Santos T. C., Rodrigues D. B., Pirraco R. P., Cerqueira M. T., Reis R. L., Correlo V. M., and Marques A. P.,
"Stem Cell-Containing Hyaluronic Acid-Based Spongy Hydrogels for Integrated Diabetic Wound Healing",
Journal Of Investigative Dermatology, vol. 137, pp. 1541-1551, doi:
10.1016/j.jid.2017.02.976, 2017.
Correia C., Santos T. C., Pirraco R. P., Cerqueira M. T., Marques A. P., Reis R. L., and Mano J. F.,
"In Vivo Osteogenic Differentiation of Stem Cells Inside Compartmentalized Capsules Loaded with Co-cultured Endothelial Cells",
Acta Biomaterialia, doi:
10.1016/j.actbio.2017.02.007, 2017.
da Silva L. P., Pirraco R. P., Santos T. C., Novoa-Carballal R., Cerqueira M. T., Reis R. L., Correlo V. M., and Marques A. P.,
"Neovascularization Induced by the Hyaluronic Acid-Based Spongy-Like Hydrogels Degradation Products",
ACS Applied Materials and Interfaces, doi:
10.1021/acsami.6b11684, 2016.
Cerqueira M. T., da Silva L. P., Santos T. C., Pirraco R. P., Correlo V. M., Reis R. L., and Marques A. P.,
"Gellan Gum-Hyaluronic Acid Spongy-like hydrogels and cells from adipose tissue synergize promoting neoskin vascularization",
ACS Applied Materials & Interfaces, doi:
10.1021/am504520j, 2014.
Cerqueira M. T., da Silva L. P., Santos T. C., Pirraco R. P., Correlo V. M., Marques A. P., and Reis R. L.,
"Human Skin Cell Fractions Fail to Self-Organize Within a Gellan Gum/Hyaluronic Acid Matrix but Positively Influence Early Wound Healing",
Tissue Engineering, Part A, pp. 1369-1378, doi:
doi:10.1089/ten.tea.2013.0460., 2014.
Cerqueira M. T., Pirraco R. P., Santos T. C., Rodrigues D. B., Frias A. M., Martins A. R., Reis R. L., and Marques A. P.,
"Cell Sheet Technology-Driven Re-epithelialization and Neovascularization of Skin Wounds",
Acta Biomaterialia, doi:
doi:10.1016/j.actbio.2014.03.006, 2014.
Popa E. G., Carvalho P. P., Dias A. F., Santos T. C., Santo V. E., Marques A. P., Viegas C. A., Dias I. R., Gomes M. E., and Reis R. L.,
"Evaluation of the in vitro and in vivo biocompatibility of carrageenan based hydrogels",
Journal of Biomedical Materials Research part A, doi:
10.1002/jbm.a.35081, 2014.
Cerqueira M. T., Pirraco R. P., Santos T. C., Rodrigues D. B., Frias A. M., Martins A. R., Reis R. L., and Marques A. P.,
"Human Adipose Stem Cells Cell Sheet Constructs impact epidermal morphogenesis in full-thickness excisional wounds",
Biomacromolecules, vol. 14, issue 11, pp. 3997-4008, doi:
10.1021/bm4011062, 2013.
Rada T., Carvalho P. P., Santos T. C., Castro A. G., Reis R. L., and Gomes M. E.,
"Chondrogenic Potential of Two hASCs Subpopulations Loaded onto Gellan Gum Hydrogel Evaluated in a Nude Mice Model",
Curr Stem Cell Res Ther. 2013 Jun 10. [Epub ahead of print], vol. 8, issue 5, pp. 357-364, doi:
10.2174/1574888X113089990049 , 2013.
Santos T. C., Hoering B., Reise K., Marques A. P., Silva S. S., Oliveira J. M., Mano J. F., Castro A. G., Reis R. L., and van Griensven M.,
"In vivo performance of chitosan/soy-based membranes as wound dressing devices for acute skin wounds",
Tissue Engineering-A, vol. 19, issue 7-8, pp. 860-870, doi:
10.1089/ten.TEA.2011.0651, 2013.
Santos T. C., Morton T., Moritz M., Pfeifer S., Reise K., Marques A. P., Castro A. G., Reis R. L., and van Griensven M.,
"VEGF and FGF-2 incorporation in starch-based bone tissue engineering constructs promote the in vivo expression of neovascularisation mediators",
Tissue Engineering-A, vol. 19, issue 7-8, pp. 834-848, doi:
DOI: 10.1089/ten.tea.2010.0741, 2013.
Pirraco R. P., Ferreira B. M., Santos T. C., Frias A. M., Marques A. P., and Reis R. L.,
"Adipose stem cell-derived osteoblasts sustain the functionality of endothelial progenitors from the mononuclear fraction of umbilical cord blood",
Acta Biomaterialia , vol. 9, issue 2, pp. 5234-5242, doi:
10.1016/j.actbio.2012.09.013, 2013.
Silva S. S., Santos T. C., Cerqueira M. T., Marques A. P., Reys L. L., Silva T. H., Caridade S. G., Mano J. F., and Reis R. L.,
"The use of ionic liquids in the processing of chitosan/silk hydrogels for biomedical applications",
Green Chemistry , vol. 14, pp. 1463-1470, doi:
10.1039/C2GC16535J, 2012.
Mendes L. F., Pirraco R. P., Szymczyk W., Frias A. M., Santos T. C., Reis R. L., and Marques A. P.,
"Perivascular-Like Cells Contribute to the Stability of the Vascular Network of Osteogenic Tissue Formed from Cell Sheet-Based Constructs",
PLoS ONE, vol. 7, issue 7, pp. e41051, doi:
10.1371/journal.pone.0041051, 2012.
Rada T., Santos T. C., Marques A. P., Correlo V. M., Frias A. M., Castro A. G., Neves N. M., Gomes M. E., and Reis R. L.,
"Osteogenic differentiation of two distinct subpopulations of human adipose-derived stem cells: an in vitro and in vivo study",
Journal of Tissue Engineering and Regenerative Medicine, DOI: 10.1002/term.388, vol. 6, pp. 1–11, 2011.
Santos T. C., Marques A. P., Silva S. S., Oliveira J. M., Mano J. F., Castro A. G., van Griensven M., and Reis R. L.,
"Chitosan improves the biological performance of soy-based biomaterials",
Tissue Engineering, vol. 16, issue 9, pp. 2883-2890, 2010.
Santos T. C., Marques A. P., Hoering B., Martins A. R., Tuzlakoglu K., Castro A. G., van Griensven M., and Reis R. L.,
"In vivo short and long term host reaction to starch-based scaffolds",
Acta Biomaterialia, vol. 6, pp. 4314-4326, 2010.
Oliveira J. T., Santos T. C., Martins L., Picciochi R., Marques A. P., Castro A. G., Neves N. M., Mano J. F., and Reis R. L.,
"Gellan Gum Injectable Hydrogels for Cartilage Tissue Engineering Applications:In Vitro Studies and Preliminary In Vivo Evaluation",
Tissue Engineering Part A, vol. 16, issue 1, pp. 343-353, 2010.
Oliveira J. T., Santos T. C., Martins L., Alves da Silva, ML, Marques A. P., Castro A. G., Neves N. M., and Reis R. L.,
"Performance of new gellan gum hydrogelscombined with human articular chondrocytesfor cartilage regeneration when subcutaneouslyimplanted in nude mice",
Journal of Tissue Engineering and Regenerative Medicine, vol. 3, issue 7, pp. 493-500, 2010.
Malafaya P. B., Oliveira J. T., Santos T. C., van Griensven M., and Reis R. L.,
"Morphometric and mechanical characterization, insulin loading and in-vivo biocompatibility of chitosan particles aggregated scaffolds for tissue engineering",
Tissue Engineering: Part A, vol. 14, issue 5, pp. 757, 2008.
Santos T. C., Marques A. P., Silva S. S., Oliveira J. M., Mano J. F., Castro A. G., and Reis R. L.,
"In vitro evaluation of the behaviour of human polymorphonuclear neutrophils in direct contact with chitosan-based membranes",
Journal of Biotechnology, vol. 132, issue 2, pp. 218-226, 2007.
Review Paper (3)
Rodrigues D. B., Oliveira J. M., Santos T. C., and Reis R. L.,
"Dendrimers: Breaking the paradigm of current musculoskeletal autoimmune therapies",
J Tissue Eng Regen Med, vol. 12, issue 3, pp. e1796-e1812, doi:
10.1002/term.2597, 2018.
Mano J. F., Silva G. A., Azevedo H. S., Malafaya P. B., Sousa R. A., Silva S. S., Boesel L. F., Oliveira J. M., Santos T. C., Marques A. P., Neves N. M., and Reis R. L.,
"Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends",
Journal of the Royal Society Interface , vol. 4, issue 17, pp. 999-1030, 2008.
Book Chapter (3)
Pinto A. R., Santos T. C., Neves N. M., and Reis R. L.,
"Testing Natural Biomaterials in Animal Models",
Natural Biomaterials for Advanced Devices and Therapies,
Eds. Neves N. M., and Reis R. L.,
Wiley Publisher, vol. 1, doi:
10.1002/9781119126218.ch30, 2016.
Invited Lecture (2)
Conference Abstract -ISI Web of Science Indexed (12)
da Silva L. P., Oliveira S., Lago M. E. L., Cerqueira M. T., Pirraco R. P., Santos T. C., Reis R. L., Correlo V. M., and Marques A. P.,
"Natural melanin promotes the differentiation of an early epidermal cell fraction and the scavenging of ROS.",
Journal of Investigative Dermatology, vol. 136, issue 5, doi:
10.1016/j.jid.2016.02.382, 2016.
Santos T. C., Pirraco R. P., Rodrigues D. B., da Silva L. P., Reis R. L., and Marques A. P.,
"Hind limb ischemia in type 1 diabetic mice as useful tool to evaluate the neovascularization of tissue engineering constructs",
Laboratory Animals, vol. 49, issue S3, pp. 41-42, doi:
10.1177/0023677215609551, 2015.
da Silva L. P., Cerqueira M. T., Pirraco R. P., Santos T. C., Reis R. L., Correlo V. M., and Marques A. P.,
"Gellan Gum-Hyaluronate Spongy-like Hydrogels Promote Angiogenesis in Hindlimb Ischemia.",
2015 4th TERMIS World Congress , doi:
10.1089/ten.tea.2015.5000.abstracts, 2015.
Santos T. C., Rodrigues D. B., Cerqueira M. T., Pirraco R. P., Castro A. G., Reis R. L., and Marques A. P.,
"Adipose Tissue-derived Stem Cells do not Elicit Alloreactivity after Chondrogenic and Osteogenic Differentiation",
Tissue Engineering Part A, vol. 21, issue S1, pp. S-1-S-413, doi:
10.1089/ten.tea.2015.5000.abstracts, 2015.
Costa M., Cerqueira M. T., Rodrigues D. B., Santos T. C., Marques A. P., Pirraco R. P., and Reis R. L.,
"Stromal Vascular Fraction Cell Sheets Angiogenic Potential for Tissue Engineering and Regenerative Medicine Applications",
Tissue Engineering Part A, vol. 21, issue S1, doi:
10.1089/ten.tea.2015.5000.abstracts., 2015.
Costa M., Cerqueira M. T., Rodrigues D. B., Santos T. C., Marques A. P., Pirraco R. P., and Reis R. L.,
"Stromal Vascular Fraction from Adipose Tissue and Cell Sheet Engineering to build Vascularization Units for Tissue Engineering and Regenerative Medicine",
Tissue Engineering Part A, doi:
10.1089/ten.tea.2014.5000.abstracts., 2014.
Santos T. C., Rodrigues D. B., Cerqueira M. T., Pirraco R. P., Marques A. P., and Reis R. L.,
"Xenogeneic M2-polarization of Macrophages by Undifferentiated and Differentiated Adipose Tissue-derived Stem Cells",
Tissue Engineering Part A, vol. 20, issue S1, pp. S113-S114, doi:
10.1089/ten.tea.2014.5000.abstracts, 2014.
Santos T. C., Rodrigues D. B., Cerqueira M. T., Silva A. C., Rodrigues A. I., Leonor I. B., Marques A. P., Castro A. G., and Reis R. L.,
"Tissue engineered constructs based on human adipose tissue derived stem cells and starch-based scaffolds for allogeneic approaches in Tissue Engineering and Regenerative Medicine",
Journal of Tissue Engineering and Regenerative Medicine, doi:
10.1002/term.2013.7.issue-s1, 2013.
Mendes L. F., Pirraco R. P., Szymczyk W., Santos T. C., Frias A. M., Reis R. L., and Marques A. P.,
"Pericytes contribute to the stability of the vascular network of osteogenic tissue formed from cell sheet-based constructs",
Journal of Tissue Engineering and Regenerative Medicine , vol. 6, issue Suppl.1, pp. 311-311, doi:
10.1002/term.1586, 2012.
Silva S. S., Duarte A. R. C., Santos T. C., Cerqueira M. T., Marques A. P., Oliveira J. M., Mano J. F., and Reis R. L.,
"Integrated strategy using ionic liquids for the design and processability of natural polymeric architectures for regenerative medicine",
Histology and Histopathology, vol. 26, issue S1, pp. 272, 2011.
Oliveira J. T., Picciochi R., Santos T. C., Martins L., Pinto L. G., Malafaya P. B., Sousa R. A., Marques A. P., Castro A. G., Mano J. F., Neves N. M., and Reis R. L.,
"Injectable gellan gum hydrogels as supports for cartilage tissue engineering applications",
Tissue Engineering Part A, vol. 14, issue 5, pp. 748-748., 2008.
Comunications - Poster (16)
Correia C., da Silva Morais A., Vilela C. A., Gertrudes A., Santos T. C., Oliveira J. M., Espregueira-Mendes J. D., Sousa R. A., and Reis R. L.,
"Stem Cells from the adipose tissue as allogenic player in cartilage repair: in vivo performance",
World Stem Cell Summi, 2014.
Cerqueira M. T., da Silva L. P., Santos T. C., Pirraco R. P., Martins A. R., Correlo V. M., Marques A. P., and Reis R. L.,
"Pre-vascularized gellan gum-hyaluronic acid spongy-like hydrogels improve skin wound healing.",
Society of Biomaterials Annual Meeting and Exposition, 2013.
Santos T. C., Cerqueira M. T., Silva A. C., Gama J. B., Rodrigues A. I., Leonor I. B., Marques A. P., Castro A. G., and Reis R. L.,
"Immunomodulatory potential of tissue engineered constructs based on human adipose tissue derived stem cells and starch-based scaffolds",
TERMIS-World 2012 Meeting, 2012.
Marques A. P., Santos T. C., da Silva R. M. P., Silva S. S., Oliveira J. M., van Griensven M., Mano J. F., Redl H., and Reis R. L.,
"Chitosan improves the in vivo biological response to soy-based biomaterials",
Society for biomaterials-Advancing disoveries from the laboratory to the clinic, 2008.
Santos T. C., Tuzlakoglu K., Morton T., Reise K., Marques A. P., Castro A. G., Redl H., Reis R. L., and van Griensven M.,
"In vivo evaluation of the suitability of starch-based scaffolds for bone tissue engineering constructs using Adipose Derived Adult Stem Cells and transgenic mice",
World Biomaterials Congress - 2008, 2008.
Santos T. C., Tuzlakoglu K., Morton T., Lang K., Reise K., Marques A. P., Castro A. G., Redl H., Reis R. L., and van Griensven M.,
"In vivo evaluation of the suitability of starch-based scaffolds for bone tissue engineering constructs using Adipose Derived Adult Stem Cells and transgenic mice",
Society for Biomaterials 2007, 2007.
Santos T. C., Tuzlakoglu K., Morton T., Lang K., Reise K., Marques A. P., Castro A. G., Redl H., Reis R. L., and van Griensven M.,
"In vivo evaluation of the suitability of starch-based scaffolds for bone tissue engineering constructs using Adipose Derived Adult Stem Cells and transgenic mice",
4th Marie Curie Cutting Edge Conference Biocompatibility evaluation and biological behaviour of polymeric biomaterials, 2007.
Comunication - Oral (24)
da Silva L. P., Pirraco R. P., Santos T. C., Novoa-Carballal R., Cerqueira M. T., Reis R. L., Correlo V. M., and Marques A. P.,
"Hyaluronidase‐mediated degradation products of hyaluronic acid‐based spongylike hydrogels promote neovascularization",
Chem2Nature Conference, 2016.
da Silva L. P., Santos T. C., Rodrigues D. B., Pirraco R. P., Cerqueira M. T., Reis R. L., Correlo V. M., and Marques A. P.,
"Stem cell-laden hyaluronic acid spongy-like hydrogels balance inflammation and promote neoinnervation of diabetic wounds",
The Gene2Skin Conference, 2016.
Santos T. C., Rodrigues D. B., Cerqueira M. T., Pirraco R. P., Castro A. G., Reis R. L., and Marques A. P.,
"Adipose Tissue-derived Stem Cells do Not Elicit Alloreactivity After Chondrogenic and Osteogenic Differentiation",
TERMIS-World-2015, doi:
10.1089/ten.tea.2015.5000.abstracts, 2015.
da Silva L. P., Oliveira S., Pirraco R. P., Santos T. C., Reis R. L., Marques A. P., and Correlo V. M.,
"Gellan gum spongy-like hydrogels containing melanin microparticles for optoelectronics",
5th International NanoMedicine Conference Sydney’s Coogee Beach, Sydney, Australia, 2014.
da Silva Morais A., Correia C., Vilela C. A., Gertrudes A., Santos T. C., Oliveira J. M., Espregueira-Mendes J. D., Sousa R. A., and Reis R. L.,
"A one-step combined therapy for cartilage repair: development and performance assessment",
EU Meeting -2014 , vol. 8, pp. 205-205, doi:
10.1002/term.1931, 2014.
Santos T. C., Morton T., Reise K., Marques A. P., Castro A. G., Redl H., van Griensven M., and Reis R. L.,
"Adipose stem cells and starch-based constructs performance on VEGFR2-LUC transgenic mice",
3rd Annual International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2008.
Santos T. C., Morton T., Reise K., Marques A. P., Castro A. G., Redl H., van Griensven M., and Reis R. L.,
"ADIPOSE STEM CELLS AND STARCH-BASED CONSTRUCTS PERFORMANCE ON VEGFR2-LUC TRANSGENIC MICE",
3rd International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2008.
Marques A. P., Santos T. C., da Silva R. M. P., Silva S. S., Oliveira J. M., van Griensven M., Mano J. F., Redl H., and Reis R. L.,
"Chitosan improves the in vivo biological response to soy-based biomaterials",
Translational Biomaterial Research Symposium, 2008.
Santos T. C., Marques A. P., Silva S. S., Oliveira J. M., Mano J. F., Castro A. G., van Griensven M., Redl H., and Reis R. L.,
"Chitosan/soy-based membranes enhance wound reepithelialization in partial thickness skin wounds",
TERMIS-EU 2008 Meeting, Porto, PT, Tissue Engineering (2008), 2008.
Oliveira J. T., Picchioci R., Santos T. C., Martins L., Pinto L. G., Malafaya P. B., Sousa R. A., Marques A. P., Castro A. G., Mano J. F., Neves N. M., and Reis R. L.,
"Injectable Gellan Gum Hydrogels as Supports for Cartilage Tissue Engineering Applications",
Tissue Engineering and Regenerative Medicine International Society (TERMIS) TERMIS-EU Porto Meeting 2008, 2008.
Santos T. C., Marques A. P., Castro A. G., van Griensven M., Redl H., and Reis R. L.,
"Long term in vivo performance of starch-based scaffolds",
TERMIS-EU 2008 Meeting, Porto, PT, Tissue Engineering (2008), 2008.
Oliveira J. T., Picchioci R., Santos T. C., Malafaya P. B., Sousa R. A., Castro A. G., Mano J. F., Neves N. M., and Reis R. L.,
"Injectable Gellan Gum Hydrogels as Supports for Cartilage Tissue Engineering Applications: In vitro characterization and initial In vivo studies",
8th World Biomaterials Congress, 2008.
Oliveira J. T., Malafaya P. B., Sousa R. A., Santos T. C., Marques A. P., Martins L., Pinto L. G., Fernandes R., Castro A. G., Mano J. F., Neves N. M., and Reis R. L.,
"GELLAN GUM HYDROGELS AS SUPPORTS FOR CARTILAGE TISSUE ENGINEERING APPROACHES: IN VITRO AND IN VIVO EVALUATION ",
4th Marie Curie Cutting Edge Conference
Biocompatibility evaluation and biological behaviour of polymeric biomaterials, 9-13 October 2007, Alvor, Algarve, Portugal , 2007.
Santos T. C., Hoering B., Marques A. P., Castro A. G., Redl H., van Griensven M., and Reis R. L.,
"In Vivo Assessment of the Inflammatory Response of Starch-based Scaffolds",
4th Marie Curie Cutting Edge Conference Biocompatibility evaluation and biological behaviour of polymeric biomaterials, 9-13 October 2007, Alvor, Algarve, Portugal, 2007.
Patent (3)
Sousa R. A., Gertrudes A., Correia C., da Silva Morais A., Gonçalves C., Radhouani H., Vilela C. A., Santos T. C., Oliveira J. M., Espregueira-Mendes J. D., and Reis R. L.,
"Viscosupplement composition comprising ulvan for treating arthritis",
WO/2015/174872, 2015.
Reis R. L., Sousa R. A., Correia C., Vilela C. A., da Silva Morais A., Gertrudes A., Oliveira J. M., Santos T. C., and Espregueira-Mendes J. D.,
"PRODUCTS FOR REPAIRING CARTILAGE LESIONS, METHOD OF PREPARATION AND USES THEREOF",
Nº: 107642 H, 2014.