Project | TERM - Programa Doutoramento Norte 2020 :: publications list |
Title | Innovative methodology for marine collagen-chitosan-fucoidan hydrogels production, tailoring rheological properties towards biomedical application |
Publication Type | Papers in Scientific Journals |
Year of Publication | 2021 |
Authors | Carvalho D. N., Gonçalves C., Oliveira J. M., Willliams D., Mearns Spragg A., Reis R. L., and Silva T. H. |
Abstract | Marine polymers such as collagen, chitosan, and fucoidan can be combined to form ionic-linked hydrogel networks towards applications in tissue engineering (TE). The use of greener approaches (as determined by green metrics – E-factor), including the absence of external chemical cross-linking agents, has advantages regarding the potential cytotoxicity. By tailoring the formulation of such an ionic-linked hydrogel, it is possible to fine-tune scaffold biofunctionality. In this study, a comparative study of composite hydrogels was accomplished, seeking to understand the correlation between polymer characteristics and physical behaviour to develop the applicability of this technology in soft-to-hard TE. Parameters such as polymer concentration, molecular weight, polymer-biomaterials bonds, biomaterial structural architecture, pore size, and mechanical rheological properties were directly correlated to the hydrogel’s formulation. The results highlight that the formulation with greatest potential was the 3-component hydrogel (H12, followed by H10, H11), due to its superior mechanical properties, making it suitable for cartilage TE. This research offers a valuable perspective on hydrogel formulation and a new processing methodology, as well as how tailoring the hydrogel composition influences mechanical behaviour to support selecting the best composition for tissue engineering applications. |
Journal | Green Chemistry |
Pagination | 1-14 |
Date Published | 2021-08-20 |
Publisher | The Royal Society of Chemistry |
ISSN | 1463-9270 |
DOI | 10.1039/D1GC02223G |
URL | https://pubs.rsc.org/en/content/articlelanding/2021/gc/d1gc02223g |
Keywords | cartilage tissue engineering, Gel strength, marine biomaterials, Marine origin biopolymers, Mechanical Properties |
Rights | restrictedAccess |
Peer reviewed | yes |
Status | published |