Project | SponGES :: publications list |
Title | 3D Biocomposites Comprising Marine Collagen and Silica-Based Materials Inspired on the Composition of Marine Sponge Skeletons Envisaging Bone Tissue Regeneration |
Publication Type | Papers in Scientific Journals |
Year of Publication | 2022 |
Authors | Martins E. G., Diogo G. S., Pires R. A., Reis R. L., and Silva T. H. |
Abstract | Ocean resources are a priceless repository of unique species and bioactive compounds with denouement properties that can be used in the fabrication of advanced biomaterials as new templates for supporting the cell culture envisaging tissue engineering approaches. The collagen of marine origin can be sustainably isolated from the underrated fish processing industry by-products, while silica and related materials can be found in the spicules of marine sponges and diatoms frustules. Aiming to address the potential of biomaterials composed from marine collagen and silica-based materials in the context of bone regeneration, four different 3D porous structure formulations (COL, COL:BG, COL:D.E, and COL:BS) were fabricated by freeze-drying. The skins of Atlantic cod (Gadus morhua) were used as raw materials for the collagen (COL) isolation, which was successfully characterized by SDS-PAGE, FTIR, CD, and amino acid analyses, and identified as a type I collagen, |
Journal | Marine Drugs |
Volume | 20 |
Issue | 11 |
Pagination | 718 |
Date Published | 2022-11-16 |
Publisher | MDPI |
ISSN | 1660-3397 |
DOI | 10.3390/md20110718 |
URL | https://www.mdpi.com/1660-3397/20/11/718 |
Keywords | 3D composites scaffold, biosilica, marine biomaterials, marine by-products, marine collagen |
Rights | openAccess |
Peer reviewed | yes |
Status | published |