Adhesive and antibacterial films based on marine-derived fucoidan and chitosan

last updated: 2022-12-21
ProjectSeaJellyBone :: publications list
TitleAdhesive and antibacterial films based on marine-derived fucoidan and chitosan
Publication TypePapers in Scientific Journals
Year of Publication2022
AuthorsCorreia C., Soares da Costa D., Inácio A. R., Vale A. C., Peixoto D., Silva T. H., Reis R. L., Pashkuleva I., and Alves N. M.

Marine-derived polymers are environmentally friendly and sustainable biomaterials that have structural similarities with the main components of the extracellular matrix. Moreover, some marine polymers have specific bioactivity that can be transferred to the systems made of these biomolecules. Herein, we developed antibacterial adhesive films combining two marine polysaccharides, namely, fucoidan and chitosan. Fucoidan was functionalized with catechol groups (FCat) to improve its adhesive properties. This modification enhanced also the fucoidan antibacterial properties: while fucoidan is active against Gram-positive bacteria, FCat showed bactericidal activity against Gram-positive and Gram-negative bacteria. To improve the processability and mechanical properties, FCat was blended with chitosan and solvent-casted to obtain films. These films exhibited an adhesion strength similar to the one of clinically used natural adhesives and no cytotoxicity: fibroblastic cells attached and remained viable on the films. Altogether our results demonstrated that the developed antibacterial and adhesive films are a feasible alternative of cytotoxic synthetic adhesives used for soft tissue healing applications.

JournalAcs Sustainable Chemistry & Engineering
Pagination16770 - 16779
Date Published2022-12-06
PublisherAmerican Chemical Society
Keywordsantibacterial films, biomimetic adhesives, marine polysaccharides, sustainable biomaterials
RightsembargoedAccess (1 Year)
Peer reviewedyes

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