Hyaluronan receptors as mediators and modulators of the tumor microenvironmen

last updated: 2023-02-24
ProjectOncoNeoTreat :: publications list
TitleHyaluronan receptors as mediators and modulators of the tumor microenvironmen
Publication TypeReview Paper
Year of Publication2023
AuthorsCarvalho A. M., Reis R. L., and Pashkuleva I.
Abstract Text

The tumor microenvironment (TME) is a dynamic and complex matter shaped by heterogenous cancer and cancer-associated cells present at the tumor site. Hyaluronan (HA) is a major TME component that plays pro-tumorigenic and carcinogenic functions. These functions are mediated by different hyaladherins expressed by cancer and tumor-associated cells triggering downstream signaling pathways that determine cell fate and contribute to TME progression towards a carcinogenic state. Here, we review the interaction of HA with several cell-surface hyaladherins – CD44, RHAMM, TLR2 and 4, LYVE-1, HARE and layilin. We discuss the signaling pathways activated by these interactions and the respective response of different cell populations within the TME, and the modulation of the TME. Potential cancer therapies via targeting these interactions are also briefly discussed.

JournalAdvanced Healthcare Materials
Date Published2023-02-17
PublisherJohn Wiley & Sons, Ltd
KeywordsCD44, HARE/Stab2, Hyaladherins, Layilin, LYVE-1, RHAMM, TLR2/4
Peer reviewedyes

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