Bioadhesive hyaluronic acid-based hydrogels for spinal cord injury

last updated: 2024-03-13
ProjectSHIFT :: publications list
TitleBioadhesive hyaluronic acid-based hydrogels for spinal cord injury
Publication TypePapers in Scientific Journals
Year of Publication2024
AuthorsDuarte D., Correia C., Reis R. L., Pashkuleva I., Peixoto D., and Alves N. M.

Spinal cord injuries (SCI) have devastating physical, psychological, and psycho-social consequences for patients. One challenge of nerve tissue repair is the lack of a natural extracellular matrix (ECM) that guides the regenerating axons. Hyaluronic acid (HA) is a major ECM component and plays a fundamental role in facilitating lesion healing. Herein, we developed HA-based adhesive hydrogels by modification of HA with dopamine, a mussel-inspired compound with excellent adhesive properties in anaqueous environment. The hydrogels were loaded with the anti-inflammatory drug ibuprofen and the response of neuronal cells (SH-SY5Y) was evaluated in terms of viability, morphology, and adhesion.The obtained results suggested that the developed materials can bridge lesion gaps, guide axonal growth, and simultaneously act as a vehicle for the delivery of bioactive compounds.

Date Published2024-02-21
PublisherAmerican Chemical Society
KeywordsAdhesive Hydrogels, Hyaluronic acid, Ibuprofen, Neuronal Regeneration, spinal cord injury
RightsembargoedAccess (1 Year)
Peer reviewedyes

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