Biomimetic supramolecular designs for the controlled release of growth factors in bone regeneration

last updated: 2016-01-20
ProjectPOLARIS :: publications list
Title Biomimetic supramolecular designs for the controlled release of growth factors in bone regeneration
Publication TypeReview Paper
Year of Publication2015
AuthorsPashkuleva I., and Azevedo H. S.
Abstract Text

The extracellular matrix (ECM) of tissues is an assembly of insoluble macromolecules that specifically interact with soluble bioactive molecules and regulate their distribution and availability to cells. Recapitulating this ability has been an important target in controlled growth factor delivery strategies for tissue regeneration and requires the design of multifunctional carriers. This review describes the integration of supramolecular interactions on the design of delivery strategies that encompass self-assembling and engineered affinity components to construct advanced biomimetic carriers for growth factor delivery. Several glycan- and peptide-based self-assemblies reported in the literature are highlighted and commented upon. These examples demonstrate how molecular design and chemistry are successfully employed to create versatile multifunctional molecules which self-assemble/disassemble in a precisely predicted manner, thus controlling compartmentalization, transport and delivery. Finally, we discuss whether recent advances in the design and preparation of supramolecular delivery systems have been sufficient to drive real translation towards a clinical impact. 

JournalAdvanced Drug Delivery Reviews
Volume94
Pagination63-76
Date Published2015-11-01
ISSN0169-409X
DOI10.1016/j.addr.2015.08.003
URLhttp://ac.els-cdn.com/S0169409X15001933/1-s2.0-S0169409X15001933-main.pdf?_tid=1e158fb4-bf69-11e5-bae4-00000aacb35f&acdnat=1453289570_2a89461f0586490802c08fa96644896e
KeywordsBiomimetic, Extracellular matrix, Glycosaminoglycans, growth factors, Molecular recognition, Multivalent interactions, peptides, self-assembly
RightsembargoedAccess (1 Year)
Peer reviewedyes
Statuspublished

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