Sulfation of Glycosaminoglycans and its Implications in Human Health and Disorders

last updated: 2017-09-18
ProjectPOLARIS :: publications list
TitleSulfation of Glycosaminoglycans and its Implications in Human Health and Disorders
Publication TypeReview Paper
Year of Publication2017
AuthorsSoares da Costa D., Reis R. L., and Pashkuleva I.
Abstract Text

Sulfation is a dynamic and complex posttranslational modification process. It can occur at various positions within the glycosaminoglycan (GAG) backbone and modulates extracellular signals such as cell–cell and cell–matrix interactions; different sulfation patterns have been identified for the same organs and cells during their development. Because of their high specificity in relation to function, GAG sulfation patterns are referred to as the sulfation code. This review explores the role of GAG sulfation in different biological processes at the cell, tissue, and organism levels. We address the connection between the sulfation patterns of GAGs and several physiological processes and discuss the misregulation of GAG sulfation and its involvement in several genetic and metabolic disorders. Finally, we present the therapeutic potential of GAGs and their synthetic mimics in the biomedical field.

JournalAnnual Review of Biomedical Engineering
Date Published2017-06-05
PublisherAnnual Reviews
KeywordsBiomaterials, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin, keratan sulfate
Peer reviewedyes

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