Papers in Scientific Journals (33)
Andrade A. L. M., da Silva L. P., Brassolatti P., Liebano R. E., Parizotto N. A., and Marques A. P.,
"Effect of photobiomodulation on the behaviour of mesenchymal stem cells in three-dimensional cultures",
Lasers in Medical Science, 38, vol. 25, issue 1, pp. 221, doi:
10.1007/s10103-023-03883-2, 2023.
Castro V. I. B., Araújo A. R., Duarte F., Sousa-Franco A., Reis R. L., Pashkuleva I., and Pires R. A.,
"Glycopeptide-based supramolecular hydrogels induce differentiation of adipose stem cells into neural lineages",
Acs Applied Materials & Interfaces, vol. 15 , issue 25, pp. 29998 - 30007, doi:
10.1021/acsami.3c05309, 2023.
Fontelo R., Soares da Costa D., Reis R. L., Novoa-Carballal R., and Pashkuleva I.,
"Block copolymer nanopatterns affect cell spreading: stem versus cancer bone cells",
Colloids and Surfaces B: Biointerfaces, vol. 219, pp. 112774, doi:
10.1016/j.colsurfb.2022.112774, 2022.
Graça A. L., Gómez-Florit M., Osório H., Rodrigues M. T., Domingues R. M. A., Reis R. L., and Gomes M. E.,
"Controlling the fate of regenerative cells with engineered platelet-derived extracellular vesicles",
Nanoscale, vol. 14, issue 17, pp. 6543-6556, doi:
10.1039/D1NR08108J, 2022.
Araszkiewicz A. M., Oliveira E. P., Svendsen T., Drela K., Rogujski P., Malysz-Cymborska I., Fiedorowicz M., Reis R. L., Oliveira J. M., Walczak P., Janowski M., Lukomska B., and Stanaszek L.,
"Manganese-Labeled Alginate Hydrogels for Image-Guided Cell Transplantation",
International Journal Of Molecular Sciences, doi:
10.3390/ijms23052465, 2022.
Pereira D. R., Silva-Correia J., Oliveira J. M., Reis R. L., and Pandit A.,
"Macromolecular modulation of a 3D hydrogel construct differentially regulates human stem cell tissue-to-tissue interface",
Materials Science & Engineering C, vol. 133, issue 2022, pp. 112611, doi:
10.1016/j.msec.2021.112611, 2021.
Lee G. W., Thangavelu M., Choi M. J., Shin E. Y., Kim H. S., Baek J. S., Jeong Y. W., Song J. E., Carlomagno C., Oliveira J. M., Reis R. L., and Khang G.,
"Exosome mediated transfer of miRNA‐140 promotes enhanced chondrogenic differentiation of bone marrow stem cells for enhanced cartilage repair and regeneration",
Journal Cellular Biochemistry, pp. 1-11, doi:
10.1002/jcb.29657, 2020.
Bastos R., Mathias M., Andrade R., Bastos R., Balduino A., Schott B., Amaral R. J. F. C., Oliveira J. M., Reis R. L., Rodeo S., and Espregueira-Mendes J.,
"Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial",
Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA, vol. 28, pp. 1989–1999, doi:
10.1007/s00167-019-05732-8, 2019.
Ballarin L., Rinkevich B., Bartscherer K., Burzynski A., Cambier S., Cammarata M., Domart-Coulon I., Drobne D., Encinas J., Frank U., Geneviere A. - M., Hobmayer B., Löhelaid H., Lyons D., Martinez P., Oliveri P., Peric L., Piraino S., Ramšak A., Rakers S.,,
"Maristem—Stem Cells of Marine/Aquatic Invertebrates: From Basic Research to Innovative Applications",
Sustainability, vol. 10, pp. 526, doi:
10.3390/su10020526, 2018.
Oliveira N. M., Martins-Cruz C., Oliveira M. B., Reis R. L., and Mano J. F.,
"Coculture of Spheroids/2D Cell Layers Using a Miniaturized Patterned Platform as a Versatile Method to Produce Scaffold-Free Tissue Engineering Building Blocks",
Advanced Biosystems, vol. 2, issue 1, pp. 1-8, doi:
10.1002/adbi.201700069, 2018.
Alves da Silva, ML, Martins A., Costa-Pinto A. R., Monteiro N., Faria S., Reis R. L., and Neves N. M.,
"Electrospun Nanofibrous Meshes Cultured With Wharton’s Jelly Stem Cell: An Alternative for Cartilage Regeneration, Without the Need of Growth Factors",
Biotechnology Journal, doi:
10.1002/biot.201700073, 2017.
da Silva L. P., Cerqueira M. T., Rodrigues D. B., Pirraco R. P., Santos T. C., Reis R. L., Correlo V. M., and Marques A. P.,
"Stem Cell-Containing Hyaluronic Acid-Based Spongy Hydrogels for Integrated Diabetic Wound Healing",
JID, vol. 137, issue 7, pp. 1541-1551, doi:
10.1016/j.jid.2017.02.976, 2017.
da Silva L. P., Santos T. C., Rodrigues D. B., Pirraco R. P., Cerqueira M. T., Reis R. L., Correlo V. M., and Marques A. P.,
"Stem Cell-Containing Hyaluronic Acid-Based Spongy Hydrogels for Integrated Diabetic Wound Healing",
Journal Of Investigative Dermatology, vol. 137, pp. 1541-1551, doi:
10.1016/j.jid.2017.02.976, 2017.
Martins M., Ribeiro D., Martins A., Reis R. L., and Neves N. M.,
"Extracellular Vesicles Derived from Osteogenically Induced Human Bone Marrow Mesenchymal Stem Cells Can Modulate Lineage Commitment",
Stem Cell Reports , vol. 6, issue 3, pp. 284-291, doi:
10.1016/j.stemcr.2016.01.001, 2016.
Popa E. G., Santo V. E., Rodrigues M. T., and Gomes M. E.,
"Magnetically-responsive hydrogels for modulation of chondrogenic differentiation",
Polymers, vol. 8, issue 2, pp. 28, doi:
10.3390/polym8020028, 2016.
Pereira D. R., López-Cebral R., Silva-Correia J., Pereira H., Espregueira-Mendes J., Silva T. H., Reis R. L., and Oliveira J. M.,
"Hyaluronic acid, stem cells and PRP/growth factors in the treatment of osteochondral lesions/Ácido hialurónico, células madre y factores de crecimiento/PRP en el tratamiento de lesiones osteocondrales.",
Trauma (Mapfre Foundation Journal), vol. In press, 2015.
Cerqueira M. T., da Silva L. P., Santos T. C., Pirraco R. P., Correlo V. M., Reis R. L., and Marques A. P.,
"Gellan Gum-Hyaluronic Acid Spongy-like hydrogels and cells from adipose tissue synergize promoting neoskin vascularization",
ACS Applied Materials & Interfaces, doi:
10.1021/am504520j, 2014.
Requicha J. F., Viegas C. A., Muñoz F., Reis R. L., and Gomes M. E.,
"Periodontal Tissue Engineering Strategies Based on Nonoral Stem Cells",
The Anatomical Record, vol. 297, issue 1, pp. 6-15, doi:
10.1002/ar.22797, 2014.
Gonçalves A. I., Rodrigues M. T., Lee S. J., Atala A., Yoo J., Reis R. L., and Gomes M. E.,
"Understanding the Role of Growth Factors in Modulating Stem Cell Tenogenesis",
PlosOne, vol. 8, issue 12, pp. 1-10, doi:
10.1371/journal.pone.0083734, 2013.
Alves da Silva, ML, Costa-Pinto A. R., Martins A., Correlo V. M., Sol P. C., Bhattacharya M., Faria S., Reis R. L., and Neves N. M.,
"Conditioned medium as a strategy for human stem cells chondrogenic differentiation",
Journal of Tissue Engineering and Regenerative Medicine, doi:
10.1002/term.1812, 2013.
Gaharwar A. K., Mihaila S. M., Swami A., Patel A., Sant A., Reis R. L., Marques A. P., Gomes M. E., and Khademhosseini A.,
"Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells.",
Advanced Materials, doi:
10.1002/adma.201300584, 2013.
Zonari A., Novikoff S., Electo N. R. P., Breyner N. M., Gomes D. A., Martins A., Neves N. M., Reis R. L., and Goes A. M.,
"Endothelial Differentiation of Human Stem Cells Seeded onto Electrospun Polyhydroxybutyrate/Polyhydroxybutyrate-Co-Hydroxyvalerate Fiber Mesh.",
PLoS One, vol. 7, issue 4, pp. e35422, doi:
10.1371/journal.pone.0035422, 2012.
Ribeiro C. A., Fraga J. S., Grãos M., Neves N. M., Reis R. L., and Khademhosseini A.,
"The secretome of stem cells isolated from the adipose tissue and Wharton jelly acts differently on central nervous system derived cell populations",
Stem Cell Research & Therapy, vol. 3, pp. 1-7, doi:
10.1186/scrt109., 2012.
Oliveira J. M., Sousa R. A., Malafaya P. B., Silva S. S., Hirose M., Ohgushi H., Mano J. F., and Reis R. L.,
"In vivo study of dendron-like nanoparticles for stem cells tune-up: From nano to tissues",
Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 7, pp. 914–924, doi:
10.1016/j.nano.2011.03.002, 2011.
Gomes S., Numata K., Leonor I. B., Mano J. F., Reis R. L., and Kaplan D. L.,
"Spider silk-bone sialoprotein fusion proteins for bone tissue engineering",
Soft Matter, vol. 7, issue 10, pp. 4964-4973, doi:
10.1039/C1SM05024A, 2011.
Rada T., Santos T. C., Marques A. P., Correlo V. M., Frias A. M., Castro A. G., Neves N. M., Gomes M. E., and Reis R. L.,
"Osteogenic differentiation of two distinct subpopulations of human adipose-derived stem cells: an in vitro and in vivo study",
Journal of Tissue Engineering and Regenerative Medicine, DOI: 10.1002/term.388, vol. 6, pp. 1–11, 2011.
Oliveira J. M., Sousa R. A., Kotobuki N., Tadokoro M., Hirose M., Mano J. F., Reis R. L., and Ohgushi H.,
"The Osteogenic Differentiation of Rat Bone Marrow Stromal Cells Cultured With Dexamethasone-loaded Carboxymethylchitosan/Poly(amidoamine) Dendrimer Nanoparticles",
Biomaterials, vol. 30, issue 5, pp. 804-813, 2008.
Cruz D. M. G., Ivirico J. L. E., Gomes M. E., Ribelles J. L., Sanchez M. S., Reis R. L., and Mano J. F.,
"Chitosan microparticles as injectable scaffolds for tissue engineering applications",
Tissue Engineering Part A, vol. 14, issue 5, pp. 821-821, 2008.
Costa P. F., Martins A., Neves N. M., Gomes M. E., and Reis R. L.,
"A novel bioreactor design for enhanced stem cells proliferation and differentiation in tissue engineered constructs",
Tissue Engineering: Part A, vol. 14, issue 5, pp. 802, 2008.
Review Paper (7)
Romano G., Mariana A., Coelho A. V., Cutignano A., Gonçalves L. G., Hansen E., Khnykin D., Mass T., Ramšak A., Rocha M. S., Silva T. H., Sugni M., Ballarin L., and Geneviere A. - M.,
"Biomaterials and Bioactive Natural Products from Marine Invertebrates: From Basic Research to Innovative Applications",
Marine Drugs, vol. 20, issue 4, pp. 219, doi:
10.3390/md20040219, 2022.
Oliveira E. P., Malysz-Cymborska I., Golubczyk D., Kalkowski L., Kwiatkowska J., Reis R. L., Oliveira J. M., and Walczak P.,
"Advances in bioinks andin vivoimaging of biomaterials for CNS applications",
Acta Biomaterialia, vol. 95, pp. 60-72, doi:
10.1016/j.actbio.2019.05.006, 2019.
Cengiz I. F., Pereira H., de Girolamo L., Cucchiarini M., Espregueira-Mendes J. D., Reis R. L., and Oliveira J. M.,
"Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room",
Journal of Experimental Orthopaedics, vol. 5, issue 1, pp. 14, doi:
10.1186/s40634-018-0133-9, 2018.
Cucchiarini M., de Girolamo L., Filardo G., Oliveira J. M., Orth P., Pape D., and Reboul P.,
"Basic science of osteoarthritis",
Journal of Experimental Orthopaedics, vol. 3, issue 22, pp. 1-18, doi:
10.1186/s40634-016-0060-6, 2016.
Monteiro N., Martins A., Reis R. L., and Neves N. M.,
"Liposomes in tissue engineering and regenerative medicine",
Journal of the Royal Society Interface, vol. 11, issue 101, pp. 20140459, doi:
10.1098/rsif.2014.0459, 2014.
Book (1)
Book Chapter (13)
Ferreira H., Fangueiro J. F., and Neves N. M.,
"The Role of Natural-Based Biomaterials in Advanced Therapies for Autoimmune Diseases",
Novel Biomaterials for Regenerative Medicine, Advances in Experimental Medicine and Biology,
Eds. Chun H. J., Park K., Kim C. - H., and Khang G.,
Springer Nature Singapore Pte Ltd., vol. 1077, pp. 127 - 146, doi:
10.1007/978-981-13-0947-2_8, 2018.
da Silva Morais A., Oliveira J. M., and Reis R. L.,
"Small Animal Models",
Osteochondral Tissue Engineering: Challenges, Current Strategies, and Technological Advances,
Eds. Oliveira J. M., Pina S., Reis R. L., and San-Román J.,
Springer, Cham, vol. 1059, pp. 423-439, doi:
10.1007/978-3-319-76735-2_19, 2018.
Canadas R. F., Pirraco R. P., Oliveira J. M., Reis R. L., and Marques A. P.,
"Stem Cells for Osteochondral Regeneration",
Osteochondral Tissue Engineering,
Eds. Oliveira J. M., Pina S., Reis R. L., and Roman J. S.,
Springer, pp. 219-240, doi:
10.1007/978-3-319-76735-2_10, 2018.
Pereira D. R., Silva-Correia J., Kon E., Pereira H., Volpi P., Espregueira-Mendes J. D., Reis R. L., and Oliveira J. M.,
"Hyaluronic acid, PRP/Growth factors and Stem cells in the Treatment of Osteochondral Lesions",
Injuries and Health Problems in Football,
Eds. Espregueira-Mendes J. D., van Dijk C. N., Neyret P., Cohen M., Villa S., Pereira H., and Oliveira J. M.,
Springer, pp. 659-677 , 2017.
da Silva Morais A., Oliveira J. M., and Reis R. L.,
"Cartilage Tissue Engineering and Regenerative Strategies",
Regenerative Strategies for the Treatment of Knee Joint Disabilities,
Eds. Oliveira J. M., and Reis R. L.,
Springer International Publishing, vol. 21, pp. 73-96, doi:
10.1007/978-3-319-44785-8_5, 2016.
Canadas R. F., Marques A. P., Reis R. L., and Oliveira J. M.,
"Osteochondral Tissue Engineering and Regenerative Strategies",
Regenerative Strategies for the Treatment of Knee Joint Disabilities,
Eds. Oliveira J. M., and Reis R. L.,
Springer International Publishing, 1, vol. 21, pp. 213-233, doi:
10.1007/978-3-319-44785-8_11, 2016.
Correia C. R., Reis R. L., and Mano J. F.,
"Multiphasic, Multistructured and Hierarchical Strategies for Cartilage Regeneration",
Engineering Mineralized and Load Bearing Tissues,
Eds. Bertassoni L. E., and Coelho P. G.,
Springer International Publishing, 1, vol. 881, issue 1, pp. 143-160, doi:
10.1007/978-3-319-22345-2, 2015.
Correia C. R., Reis R. L., and Mano J. F.,
"Nanostructured Capsules for Cartilage Tissue Engineering",
Methods in Molecular Biology,
Eds. Doran P. M.,
Springer, vol. 1340, pp. 181-189, doi:
10.1007/978-1-4939-2938-2_13, 2015.
Gonçalves A. I., Costa-Almeida R., Gershovich P., Rodrigues M. T., Reis R. L., and Gomes M. E.,
"Cell-Based Approaches for Tendon Regeneration",
Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes,
Eds. Gomes M. E., Reis R. L., and Rodrigues M. T.,
Elsevier , pp. 187–203, doi:
10.1016/B978-0-12-801590-2.00006-5, 2015.
Canadas R. F., Pina S., Marques A. P., Oliveira J. M., and Reis R. L.,
"Cartilage and Bone Regeneration – How close are we to bedside?",
Translating Regenerative Medicine to the Clinic,
Eds. Laurence J., Van Beusekom M., Baptista P., and Atala A.,
Elsevier, 1, vol. 1, pp. 89-106, doi:
http://dx.doi.org/10.1016/B978-0-12-800548-4.00007-3, 2014.
Randelli P., Menon A., Ragone V., Carmont M. R., Espregueira-Mendes J. D., Marcacci M., Neil J., Oliveira J. M., Ortolani A., Azzalini E., Pereira H., Silva-Correia J., Reis R. L., Ripóll P., Russo A., Cabitza P., and Banfi G.,
"Head, Low-Back and Muscle Injuries in Athletes: PRP and Stem Cells in Sports-Related Diseases",
ESSKA Instructional Course Lecture Book,
Eds. Zaffagnini S., Becker R., Kerkhoffs G. M. M. J., Espregueira-Mendes J. D., and Niek V. D. C.,
Springer Berlin Heidelberg, pp. 273-311, 2014.
Salgado A. J., Oliveira J. M., Martins A., Teixeira F. G., Silva N. A., Neves N. M., Sousa N., and Reis R. L.,
"Tissue Engineering and Regenerative Medicine: Past, Present, and Future",
Tissue Engineering of the Peripheral Nerve: Stem Cells and Regeneration Promoting FactorsAcademic Press,
Eds. Geuna S., Perroteau I., Tos P., and Battiston B.,
Academic Press, vol. 108, pp. 1-33, doi:
10.1016/B978-0-12-410499-0.00001-0, 2013.
Oliveira J. M., Mano J. F., Ohgushi H., and Reis R. L.,
"Nanotechnology and Stem Cell-based Strategies for Regenerative Medicine Applications",
Making Research Visible to the World, In Canon Foundation in Europe - Canon Alumni Book,
Eds. Europe C. F.,
Published by Canon Foundation in Europe,
Amstelveen, pp. 50-53, 2010.
Invited Review Paper (4)
Teixeira S. P. B., Domingues R. M. A., Shevchuk M., Gomes M. E., Peppas N. A., and Reis R. L.,
"Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior",
Advanced Functional Materials, vol. 30, issue 44, pp. 1909011, doi:
10.1002/adfm.201909011, 2020.
Invited Lecture (10)
Conference Abstract -ISI Web of Science Indexed (10)
Teixeira S. P. B., Pardo A., Bakht S. M., Gómez-Florit M., Reis R. L., Gomes M. E., and Domingues R. M. A.,
"3D Biomimetic Constructs Steer Stem Cell Commitment By Synergistic Modulation Of Biophysical Cues And Growth Factor Signalling",
Orthopaedic Proceedings, vol. 106-B, issue SUPP_1, pp. 13, doi:
10.1302/1358-992X.2024.1.013, 2024.
Costa-Pinto A. R., Serre-Miranda C., Cerqueira-Rodrigues B., Martins A., Alves da Silva M. L., Correia-Neves M., and Neves N. M.,
"Artificial thymus_ a tissue engineering strategy",
Tissue Engineering Part A, vol. 21, pp. S-1-S-413, doi:
10.1089/ten.tea.2015.5000.abstracts., 2015.
Correia C. R., Gil S., Reis R. L., and Mano J. F.,
"Chondrogenic Differentiation Within Magnetic-multilayered Liquified Capsules Containing Collagen II/TGF-β3 Microparticles",
Tissue Engineering Part A, vol. 21, issue S1, pp. S1-S413, doi:
10.1089/ten.tea.2015.5000.abstracts, 2015.
Correia C. R., Pirraco R. P., Cerqueira M. T., Marques A. P., Reis R. L., and Mano J. F.,
"Osteogenic Differentiation of Adipose Stem Cells by Endothelial Cells Co-culture Within Liquified Capsules",
Tissue Engineering Part A, vol. 21, issue S1, pp. S1-S413, doi:
10.1089/ten.tea.2015.5000.abstracts, 2015.
Correia C. R., Pirraco R. P., Cerqueira M. T., Marques A. P., Reis R. L., and Mano J. F.,
"Paracrine signalling between adipose tissue stem and microvascular endothelial cells within multilayered capsules trigger osteoblastogenesis.",
Journal of Tissue Engineering and Regenerative Medicine, vol. 8, issue s1, pp. 39-206, doi:
10.1002/term.1931, 2014.
Gonçalves A. I., Rodrigues M. T., Santo V. E., Reis R. L., and Gomes M. E.,
"Magnetic nanoparticles potential for stem cell functionalization",
Journal of Tissue Engineering and Regenerative Medicine, vol. 7, issue s1, pp. 26-26, doi:
10.1002/term.1822, 2013.
Popa E. G., Rodrigues M. T., Santo V. E., Gonçalves A. I., Reis R. L., and Gomes M. E.,
"Magnetic-responsive hydrogels for cartilage tissue engineering",
Journal of Tissue Engineering and Regenerative Medicine, vol. 7, issue s1, pp. 22-22, doi:
10.1002/term.1822, 2013.
Costa-Pinto A. R., Aleixo I., Cerqueira M. T., Frias A. M., Fernandes S., Barros A., Reis R. L., and Neves N. M.,
"Fetal stem cells obtained from amniotic fluid and wharton's jelly expanded using platelet lysate for tissue engineering applications.",
Journal of Tissue Engineering and Regenerative Medicine, vol. 6, pp. 9-9, doi:
10.1002/term.1608, 2012.
Silva S. S., Popa E. G., Gomes M. E., Oliveira M. B., Mano J. F., and Reis R. L.,
"Designing silk fibroin-based matrices with ionic liquids for tissue engineering strategies using human adipose stem cells",
Journal of Tissue Engineering and Regenerative Medicine, vol. 6, issue Suppl 2, pp. 17, 2012.
Frias A. M., Dias I. R., Viegas C. A. A., Fernandes S., Barros A., Azevedo J. T., Neves N. M., and Reis R. L.,
"In Vivo Engraftment Potential of human Bone Marrow and Amniotic Fluid Stem Cells Cultured under Osteogenic Conditions",
Tissue Engineering: Part A, vol. 14, issue 5, pp. 746, doi:
10.1089/tea.2008.1504, 2008.