Magnetic-responsive hydrogels for cartilage tissue engineering

last updated: 2013-10-15
TitleMagnetic-responsive hydrogels for cartilage tissue engineering
Publication TypeConference Abstract -ISI Web of Science Indexed
Year of Publication2013
AuthorsPopa E. G., Rodrigues M. T., Santo V. E., Gonçalves A. I., Reis R. L., and Gomes M. E.

The use of magnetic nanoparticles (MNPs) has been explored as an alternative approach to overcome current limitations of regenerative medicine strategies. Cell engineering approaches where MNPs are incorporated within three-dimensional constructs, such as scaffolds or hydrogels may constitute a novel and attractive approach towards the development of a magnetically-responsive system. These systems would enable remote controlled actions over tissue engineered constructs in vitro and in vivo. Moreover, growing evidence suggests that the application of a magnetic field may enhance biological performance over commonly used static culture conditions providing stimulation for cell proliferation, migration and differentiation.

In this work we analyze the role of magnetic stimulation on the behavior of human adipose derived stem cells (hASCs) laden in k-carrageenan hydrogels aiming at cartilage tissue engineering approaches. Thermo-responsive natural-based κ-carrageenan hydrogels were used as 3D templates since previous studies(1) report the adequate environment provided by these materials to support the viability and chondrogenic differentiation of several types of cells.

JournalJournal of Tissue Engineering and Regenerative Medicine
Conference NameTerm Stem 2013
Date Published2013-09-30
PublisherWiley & Sons, Inc.
Conference LocationPorto
DOI 10.1002/term.1822
KeywordsCartilage TE, Hydrogels, Magnetic nanoparticles, Stem cells
Peer reviewedyes

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