Papers in Scientific Journals (29)
Martins A. M., Kretlow J. D., Costa-Pinto A. R., Malafaya P. B., Fernandes E. M., Neves N. M., Alves C. M., Mikos A. G., Kasper F. K., and Reis R. L.,
"Gradual pore formation in natural origin scaffolds throughout subcutaneous implantation",
Journal of Biomedical Materials Research: Part A, vol. 100, issue 3, pp. 599-612, doi:
10.1002/jbm.a.33261, 2012.
Oliveira J. M., Sousa R. A., Malafaya P. B., Silva S. S., Hirose M., Ohgushi H., Mano J. F., and Reis R. L.,
"In vivo study of dendron-like nanoparticles for stem cells tune-up: From nano to tissues",
Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 7, pp. 914–924, doi:
10.1016/j.nano.2011.03.002, 2011.
Oliveira J. T., Martins L., Picciochi R., Malafaya P. B., Sousa R. A., Neves N. M., Mano J. F., and Reis R. L.,
"Gellan gum: A new biomaterial for cartilage tissue engineering applications",
Journal of Biomedical Materials Research 93A: 852–863, 2010, vol. 93, issue 3, pp. 852-863, doi:
10.1002/jbm.a.32574., 2010.
Oliveira J. T., Correlo V. M., Sol P. C., Costa-Pinto A. R., Malafaya P. B., Salgado A. J., Bhattacharya M., Charbord P., Neves N. M., and Reis R. L.,
"Assessment of the Suitability of Chitosan/PolyButylene Succinate Scaffolds Seeded with Mouse Mesenchymal Progenitor Cells for a Cartilage Tissue Engineering Approach",
Tissue Engineering - Part A , vol. 14, issue 10, pp. 1651-1661, 2010.
Oliveira J. M., Costa S. A., Leonor I. B., Malafaya P. B., Mano J. F., and Reis R. L.,
"Novel hydroxyapatite/carboxymethyl chitosan composite scaffolds prepared combining an innovative 'autocatalytic' electroless co-precipitation route ",
Journal Biomedical Materials Research: Part A, vol. 88A, issue 2, pp. 470-480, 2009.
Oliveira J. M., Silva S. S., Malafaya P. B., Rodrigues M. T., Kotokuki N., Hirose M., Gomes M. E., Mano J. F., Ohgushi H., and Reis R. L.,
"Macroporous hydroxyapatite scaffolds for bone tissue engineering applications: Physicochemical characterization and assessment of rat bone marrow stromal cells viability",
Journal of Biomedical Materials Research: Part A, vol. 91, issue 1, pp. 175-186, 2009.
Oliveira J. M., Malafaya P. B., Silva S. S., Kotobuki N., Hirose M., Sousa R. A., Ohgushi H., Mano J. F., and Reis R. L.,
"Carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles as an intracellular delivery system of dexamethasone for inducing stem cells osteogenic differentiation and de novo bone formation",
Tissue Engineering and Regenerative Medicine, vol. 6, issue 12, pp. S252, 2009.
Martins A. M., Pham Q. P., Malafaya P. B., Raphael R. M., Kasper F. K., Reis R. L., and Mikos A. G.,
"Natural stimulus responsive scaffolds/cells for bone tissue engineering: influence of lysozyme upon scaffold degradation and osteogenic differentiation of cultured marrow stromal cells induced by CaP coatings ",
Tissue Engineering: Part A, vol. 15, issue 8, pp. 1953-1963, 2009.
Martins A. M., Pham Q. P., Malafaya P. B., Sousa R. A., Gomes M. E., Raphael R. M., Kasper F. K., Reis R. L., and Mikos A. G.,
"The role of lipase and alpha-amylase in both the degradation of starch/poly(epsilon-caprolactone) fiber meshes and the osteogenic differentiation of cultured marrow stromal cells",
Tissue Engineering: Part A, vol. 15, issue 2, pp. 295-305, 2009.
Martins A. M., Pham Q. P., Malafaya P. B., Raphael R. M., Kasper F. K., Reis R. L., and Mikos A. G.,
""Smart'' and stimulus responsive chitosan-based scaffolds/cells for bone tissue engineering: Influence of lysozyme upon scaffold degradation and osteogenic differentiation of cultured marrow stromal cells induced by cap coatings",
Tissue Engineering Part A, vol. 14, issue 5, pp. 795-795, 2008.
Martins A. M., Santos M. I., Azevedo H. S., Malafaya P. B., and Reis R. L.,
"Natural origin scaffolds with in situ pore forming capability for bone tissue engineering applications",
Acta Biomaterialia, vol. 4, issue 6, pp. 1637-1645, 2008.
Mano J. F., Oliveira J. T., Alves C. M., Malafaya P. B., and Reis R. L.,
"Bone, cartilage and osteochondral tissue engineering strategies using natural origin polymers and ceramics, growth factors and progenitor cells",
Tissue Engineering: Part A, vol. 14, issue 5, pp. 707, 2008.
Malafaya P. B., Oliveira J. T., Santos T. C., van Griensven M., and Reis R. L.,
"Morphometric and mechanical characterization, insulin loading and in-vivo biocompatibility of chitosan particles aggregated scaffolds for tissue engineering",
Tissue Engineering: Part A, vol. 14, issue 5, pp. 757, 2008.
Oliveira A. L., Malafaya P. B., Costa S. A., Sousa R. A., and Reis R. L.,
"Micro-computed tomography (mu-CT) as a potential tool to assess the effect of dynamic coating routes on the formation of biomimetic apatite layers on 3D-plotted biodegradable polymeric scaffolds",
Journal of Materials Science-Materials in Medicine, vol. 18, issue 2, pp. 211-223, 2007.
Gomes M. E., Ribeiro A. S., Malafaya P. B., Reis R. L., and Cunha A. M.,
"A New Approach Based on Injection Moulding to Produce Biodegradable Starch Based Polymeric Scaffolds: Morphology, Mechanical and Degradation Behaviour",
Biomaterials, vol. 22, pp. 883, 2007.
Oliveira J. M., Rodrigues M. T., Silva S. S., Malafaya P. B., Gomes M. E., Viegas C. A. A., Azevedo J. T., Dias I. R., Mano J. F., and Reis R. L.,
"Novel hydroxyapatite/chitosan bilayered scaffold for osteochondral tissue-engineering applications: scaffold design and its performance when seeded with goat bone marrow stromal cells",
Biomaterials, vol. 27, pp. 6123-6137, 2006.
Malafaya P. B., Pedro A. J., Peterbauer A., Gabriel C., Redl H., and Reis R. L.,
"Chitosan particles agglomerated scaffolds for cartilage and osteochondral tissue engineering approaches with adipose tissue derived stem cells (vol 17, pg 675, 2006)",
Journal of Materials Science-Materials in Medicine, vol. 17, issue 7, pp. 675-675, 2006.
Malafaya P. B., Pedro A. J., Peterbauer A., Gabriel C., Redl H., and Reis R. L.,
"Chitosan particles agglomerated scaffolds for cartilage and osteochondral tissue engineering approaches with adipose tissue derived stem cells",
Journal of Materials Science: Materials in Medicine, vol. 16, pp. 1077-1085, 2005.
Malafaya P. B., Elvira C., Gallardo A., Roman J. S., and Reis R. L.,
"Porous starch-based drug delivery system processed by a microwave route",
Journal of Biomaterials Science: Polymer Edition, vol. 12, issue 11, pp. 1227-1241, 2001.
Review Paper (1)
Mano J. F., Silva G. A., Azevedo H. S., Malafaya P. B., Sousa R. A., Silva S. S., Boesel L. F., Oliveira J. M., Santos T. C., Marques A. P., Neves N. M., and Reis R. L.,
"Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends",
Journal of the Royal Society Interface , vol. 4, issue 17, pp. 999-1030, 2008.
Book Chapter (21)
Correlo V. M., Gomes M. E., Tuzlakoglu K., Oliveira J. M., Malafaya P. B., Mano J. F., Neves N. M., and Reis R. L.,
"Tissue Engineering Using Natural Polymers",
Biomedical Polymers ,
Eds. Jenkins M.,
Woodhead publishing Ltd ,
Cambridge, pp. 197-217, 2008.
Gomes M. E., Azevedo H. S., Malafaya P. B., Silva S. S., Oliveira J. M., Silva G. A., Sousa R. A., Mano J. F., and Reis R. L.,
"Natural Polymers in tissue engineering applications",
Textbook on tissue engineering,
Eds. van Blitterswijk C.,
Elsevier,
Amsterdam, 2007.
Invited Journal Paper (1)
Book Chapter (21)
Azevedo H. S., Gomes M. E., Malafaya P. B., Marques A. P., Salgado A. J., and Reis R. L.,
"Natural Origin Degradable Polymers in Biomedical Applications",
Handbook of Biodegradable Polymeric Materials and Their Applications,
American Scientific Publishers,
California, pp. 13-31, 2006.
Malafaya P. B., Gomes M. E., Salgado A. J., and Reis R. L.,
"Polymer based scaffolds and carriers for bioactive agents from different natural origin materials",
Tissue Engineering, Stem Cells, and Gene Therapies - Advances in Experimental Medicine and Biology S,
Kluwer Academic/Plenum Publishers,
London, pp. 534:201-233, 2003.
Oliveira A. L., Leonor I. B., Malafaya P. B., Alves C. M., Azevedo H. S., and Reis R. L.,
"Tailoring the bioactivity of natural origin based polymers systems: from bone-analogue composites to an all range of biomimetic calcium-phosphate coating methodologies",
Bioceramics 15,
Trans Tech Pub,
Zurich, pp. 111-142, 2002.
Malafaya P. B., Ribeiro A. S., Fernandes M. H., Correia R. N., and Reis R. L.,
"Innovative Methodologies for Producing Bioactive Glass-Ceramics and Porous HA/TCP Bi-phasic Ceramics",
Bioceramics 12,
World Scientific Publishers,
Singapore, pp. 387-401, 1999.
Invited Lecture (3)
Conference Abstract -ISI Web of Science Indexed (3)
Martins A., Pinho E. D., Malafaya P. B., Marques A. P., Reis R. L., and Neves N. M.,
"Micro-nano composite mesh scaffold in mouse MPC osteogenic differentiation",
TISSUE ENGINEERING , vol. 13, pp. 1727, 2010.
Oliveira J. M., Sousa R. A., Kotobuki N., Malafaya P. B., Hirose M., Mano J. F., Reis R. L., and Ohgushi H.,
"Dexamethasone-loaded Carboxymethylchitosan/poly(amidoamine) Dendrimer Nanoparticles Enhances Bone Formation In Vivo",
Tissue Engineering: Part A, vol. 14, pp. 721, 2008.
Oliveira J. T., Picciochi R., Santos T. C., Martins L., Pinto L. G., Malafaya P. B., Sousa R. A., Marques A. P., Castro A. G., Mano J. F., Neves N. M., and Reis R. L.,
"Injectable gellan gum hydrogels as supports for cartilage tissue engineering applications",
Tissue Engineering Part A, vol. 14, issue 5, pp. 748-748., 2008.
Comunications - Poster (30)
Oliveira J. M., Malafaya P. B., Silva S. S., Kotokuki N., Hirose M., Sousa R. A., Ohgushi H., Mano J. F., and Reis R. L.,
"Carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles as an intracellular delivery system of dexamethasone for inducing stem cells osteogenic differentiation and de novo bone formation ",
TERMIS 2nd World Congress 2009, 2009.
Martins A. M., Kasper F. K., Kretlow J. D., Costa-Pinto A. R., Malafaya P. B., Neves N. M., Alves C. M., Reis R. L., and Mikos A. G.,
"In Vivo Responsive Scaffolds with the Ability of In Situ Pore Formation: A Novel Strategy for Bone Tissue Engineering",
2nd TERMIS World Congress, 2009.
Comunication - Oral (30)
Oliveira J. M., Sousa R. A., Kotobuki N., Malafaya P. B., Silva S. S., Hirose M., Ohgushi H., Mano J. F., and Reis R. L.,
"Dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles as a intracellular delivery system for bone tissue engineering",
1st IBB Meeting , 2009.
Oliveira J. T., Picchioci R., Santos T. C., Martins L., Pinto L. G., Malafaya P. B., Sousa R. A., Marques A. P., Castro A. G., Mano J. F., Neves N. M., and Reis R. L.,
"Injectable Gellan Gum Hydrogels as Supports for Cartilage Tissue Engineering Applications",
Tissue Engineering and Regenerative Medicine International Society (TERMIS) TERMIS-EU Porto Meeting 2008, 2008.
Oliveira J. M., Sousa R. A., Kotobuki N., Malafaya P. B., Hirose M., Mano J. F., Reis R. L., and Ohgushi H.,
"Dexamethasone-loaded Carboxymethylchitosan/poly(amidoamine) Dendrimer Nanoparticles Enhances Bone Formation In Vivo",
Annual Tissue Engineering and Regenerative Medicine International Society - TERMIS-EU Meeting, 2008.
Oliveira J. T., Picchioci R., Santos T. C., Malafaya P. B., Sousa R. A., Castro A. G., Mano J. F., Neves N. M., and Reis R. L.,
"Injectable Gellan Gum Hydrogels as Supports for Cartilage Tissue Engineering Applications: In vitro characterization and initial In vivo studies",
8th World Biomaterials Congress, 2008.
Oliveira J. T., Malafaya P. B., Sousa R. A., Santos T. C., Marques A. P., Martins L., Pinto L. G., Fernandes R., Castro A. G., Mano J. F., Neves N. M., and Reis R. L.,
"GELLAN GUM HYDROGELS AS SUPPORTS FOR CARTILAGE TISSUE ENGINEERING APPROACHES: IN VITRO AND IN VIVO EVALUATION ",
4th Marie Curie Cutting Edge Conference
Biocompatibility evaluation and biological behaviour of polymeric biomaterials, 9-13 October 2007, Alvor, Algarve, Portugal , 2007.