Harnessing magnetic-mechano actuation in regenerative medicine and tissue engineering

last updated: 2015-11-09
ProjectPOLARIS :: publications list
TitleHarnessing magnetic-mechano actuation in regenerative medicine and tissue engineering
Publication TypeReview Paper
Year of Publication2015
AuthorsSantos L., Reis R. L., and Gomes M. E.
Abstract Text

Mechanical stimulus is of upmost importance in tissues developmental and regeneration processes as well as in maintaining body homeostasis. Classical physiological reactions encompass an increase of blood vessel diameter upon exposure to high blood pressure, or the expansion of cortical bone after continuous high-impact exercise. At a cellular level, it is well established that extracellular stiffness, topography, and remote magnetic actuation are instructive mechanical signals for stem cell differentiation. Based on this, biomaterials and their properties can be designed to act as true stem cell regulators, eventually leading to important advances in conventional tissue engineering techniques. This review identifies the latest advances and tremendous potential of magnetic actuation within the scope of regenerative medicine and tissue engineering. 

JournalTrends in Biotechnology
Date Published2015-06-26
Keywordsmagnetic actuation, regenerative medicine, Stem cells
Peer reviewedyes

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