Papers in Scientific Journals (1506)
Bessa P. C., Machado R., Nürnberger S., Dopler D., Meinl A., Banerjee A., Cunha A. M., Rodríguez-Cabello J. C., Redl H., van Griensven M., Reis R. L., and Casal M.,
"Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs",
Journal of Controlled Release, vol. 142, pp. 312-318, 2010.
Silva N. A., Salgado A. J., Sousa R. A., Oliveira J. T., Pedro A. J., Leite-Almeida H., Cerqueira R., Almeida A., Mastronardi F., Mano J. F., Neves N. M., Sousa N., and Reis R. L.,
"Development and characterization of a novel hybrid tissue engineering-based scaffold for spinal cord injury repair",
Tissue Engineering Part A, vol. 16, issue 1, pp. 45-54, 2010.
Chung S., Martins A., Correlo V. M., Oliveira J. T., Marques A. P., Neves N. M., Mano J. F., Sousa R. A., and Reis R. L.,
"Dependence of cell proliferation on the morphology of starch based scaffolds for tissue engineering",
TISSUE ENGINEERING PART A, vol. 14, issue 5, pp. 718-718, 2010.
Cerqueira M. T., Martins A., Rada T., Gomes M. E., Marques A. P., Neves N. M., and Reis R. L.,
"Human Dermal Fibroblasts, Keratinocytes and Adipose Stem Cells Behaviour on Patterned Electrospun Nanofiber Meshes",
Tissue Engineering: Part A, vol. 14,5, issue 5, pp. 742, 2010.
Bessa P. C., Balmayor E. R., Hartinger J., Zanoni G., Dopler D., Meinl A., Banerjee A., Casal M., Redl H., Reis R. L., and van Griensven M.,
"Silk fibroin microparticles as carriers for delivery of human recombinant BMP-2. In vitro and in vivo bioactivity",
Tissue Engineering Part C, 2010.
Grenha A., Gomes M. E., Rodrigues M. T., Santo V. E., Mano J. F., Neves N. M., and Reis R. L.,
"Development of newchitosan/carrageenan nanoparticles for drug delivery and tissue engineeringapplications",
Journal of Biomedical Materials Research Part A, vol. 92A, issue 4, pp. 1265-1272, 2010.
Alves da Silva, ML, Crawford A., Mundy J. M., Correlo V. M., Sol P. C., Battacharya M., Hatton P. V., Reis R. L., and Neves N. M.,
"Chitosan/Polyester-Based Scaffolds For Cartilage Tissue Engineering: Assessment of Extracellular Matrix Formation",
Acta Biomaterialia, vol. 6, issue 3, pp. 1149–1157, 2010.
Lopez-Perez P. M., da Silva R. M. P., Serra C., Pashkuleva I., and Reis R. L.,
"Surface phosphorylation of chitosan significantly improves Osteoblast cells viability, attachment and proliferation ",
Journal of Materials Chemistry, vol. 20, issue 3, pp. 483-491, 2010.
Oliveira J. M., Costa S. A., Leonor I. B., Malafaya P. B., Mano J. F., and Reis R. L.,
"Novel hydroxyapatite/carboxymethyl chitosan composite scaffolds prepared combining an innovative 'autocatalytic' electroless co-precipitation route ",
Journal Biomedical Materials Research: Part A, vol. 88A, issue 2, pp. 470-480, 2009.
Alves N. M., Shi J., Oramas E., Santos J. L., Tomás H., and Mano J. F.,
"Bioinspired superhydrophobic poly(L-lactic acid) surfaces prevent the adhesion and proliferation of bone marrow derived cells",
Journal of Biomedical Materials Research Part A, vol. 91A, pp. 480-488, 2009.
Lopéz-Álvarez M., Solla E. L., González P., Serra J., León B., Marques A. P., and Reis R. L.,
"Silicon - Hydroxyapatite Bioactive Coatings (Si-HA) from Diatomaceous Earth and SiO2. Study of adhesion and proliferation of osteoblast-like cells",
Journal of Material Science: Materials in Medicine, vol. 20, pp. 1131-1136, 2009.
Tuzlakoglu K., Pashkuleva I., Rodrigues M. T., Gomes M. E., van Lenthe G. H., Muller R., and Reis R. L.,
"A new route to produce starch-based fiber mesh scaffolds by wet spinning and subsequent surface modification as a way to improve cell attachment and proliferation",
J Biomed Mater Res, vol. 92A, pp. 369–377, 2009.
Isakov D., Martins A., de Matos Gomes E., Bdikin I., Guimarães A. C., Dekola T., Almeida B., Neves N. M., Reis R. L., and Macedo F.,
"Synthesis of polymer-based triglycine sulfate nanofibres by electrospinning",
Journal of Physics D: Applied Physics, vol. 20, pp. 205403, 2009.
Martins A. M., Pereira R. C., Leonor I. B., Azevedo H. S., and Reis R. L.,
"Chitosan scaffolds incorporating lysozyme into CaP coatings produced by a biomimetic route: a novel concept for tissue engineering combining a self-regulated degradation system with in situ pore formation",
Acta Biomaterialia, vol. 5, issue 9, pp. 3328–3336, 2009.
Alves da Silva, ML, Crawford A., Mundy J. M., Correlo V. M., Sol P. C., Bhattacharya M., Hatton P. V., Reis R. L., and Neves N. M.,
"Chitosan/ Polyester – Based Scaffolds For Cartilage Tissue Engineering: Assessment of Extracellular Matrix Formation",
Acta Biomaterialia, vol. 6, pp. 1149–1157, 2009.
Oliveira J. M., Silva S. S., Malafaya P. B., Rodrigues M. T., Kotokuki N., Hirose M., Gomes M. E., Mano J. F., Ohgushi H., and Reis R. L.,
"Macroporous hydroxyapatite scaffolds for bone tissue engineering applications: Physicochemical characterization and assessment of rat bone marrow stromal cells viability",
Journal of Biomedical Materials Research: Part A, vol. 91, issue 1, pp. 175-186, 2009.
Oliveira J. M., Malafaya P. B., Silva S. S., Kotobuki N., Hirose M., Sousa R. A., Ohgushi H., Mano J. F., and Reis R. L.,
"Carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles as an intracellular delivery system of dexamethasone for inducing stem cells osteogenic differentiation and de novo bone formation",
Tissue Engineering and Regenerative Medicine, vol. 6, issue 12, pp. S252, 2009.
Pereira V. H., Cerqueira S. R., Fraga J. S., Oliveira J. M., Mano J. F., Salgado A. J., Reis R. L., and Sousa N.,
"Dose dependent effects of FITC-labeled CMC/PAMAM dendrimer nanoparticles on central nervous system derived cells: In vitro and in vivo evaluation",
Tissue Engineering and Regenerative Medicine, vol. 6, issue 12, pp. S119, 2009.
Antunes J. C., Oliveira J. M., Reis R. L., Soria J. M., Gómez-Ribelles J. L., and Mano J. F.,
"Novel poly(L-lactic acid)/hyaluronic acid macroporous hybrid scaffolds: Physicochemical characterization and assessment of cytotoxicity in vitro",
Tissue Engineering and Regenerative Medicine, vol. 6, issue 12, pp. S34, 2009.
Martins A., Pinho E. D., Faria S., Pashkuleva I., Marques A. P., Reis R. L., and Neves N. M.,
"Surface Modification of Electrospun Polycaprolactone Nanofiber Meshes by Plasma Treatment to Enhance Biological Performance",
Small, vol. 10, pp. 1195-1206, 2009.
Martins A. M., Pham Q. P., Malafaya P. B., Raphael R. M., Kasper F. K., Reis R. L., and Mikos A. G.,
"Natural stimulus responsive scaffolds/cells for bone tissue engineering: influence of lysozyme upon scaffold degradation and osteogenic differentiation of cultured marrow stromal cells induced by CaP coatings ",
Tissue Engineering: Part A, vol. 15, issue 8, pp. 1953-1963, 2009.
Costa R. R., Custódio C. A., Testera A. M., Arias F. J., Rodríguez-Cabello J. C., Alves N. M., and Mano J. F.,
"Stimuli-Responsive Thin Coatings Using Elastin-Like Polymers for Biomedical Applications",
Advanced Functional Materials, vol. 19, issue 20, pp. 3210-3218, doi:
10.1002/adfm.200900568, 2009.
Costa-Pinto A. R., Correlo V. M., Sol P. C., Bhattacharya M., Charbord P., Delorme B., Reis R. L., and Neves N. M.,
"Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Seeded on Melt based Chitosan scaffolds for Bone Tissue Engineering Applications",
Biomacromolecules, vol. 10, issue 8, pp. 2067-2073, 2009.
Barbosa J. S., Costa R. R., Alonso M., Rodríguez-Cabello J. C., and Mano J. F.,
"Multi-Layered Films Containing a Biomimetic Stimuli-Responsive Recombinant Protein",
Nanoscale Research Letters, vol. 4, issue 10, pp. 1247-1253, doi:
10.1007/s11671-009-9388-5, 2009.
Santos M. I., Pashkuleva I., Alves C. M., Gomes M. E., Fuchs S., Unger R. E., Reis R. L., and Kirkpatrick C. J.,
"Surface-modified 3D starch-based scaffold for improved endothelialization for bone tissue engineering",
Journal of Materials Chemistry, vol. 19, issue 24, pp. 4091–4101, 2009.
Alves da Silva, ML, Crawford A., Mundy J. M., Martins A., Araujo J. V., Hatton P. V., Reis R. L., and Neves N. M.,
"Evaluation of Extracellular Matrix Formation in PCL and SPCL Nanofiber Meshes When Seeded With Bovine Articular Chondrocytes",
Tissue Engineering: Part A, vol. 15, issue 2, pp. 377-385, 2009.
Martins A., Sangwon C., Pedro A. J., Sousa R. A., Marques A. P., Reis R. L., and Neves N. M.,
"Hierarchical starch-based fibrous scaffolds for bone tissue engineering applications",
Journal of Tissue Engineering and Regenerative Medicine, vol. 3, pp. 37-42, 2009.
Salgado A. J., Sousa R. A., Fraga J. S., Pego J. M., Silva B. A., Malva J. O., Neves N. M., Reis R. L., and Sousa N.,
"Effects of Starch/ Polycaprolactone-based Blends for Spinal Cord Injury Regeneration in Neurons/Glial Cells Viability and Proliferation",
Journal of Bioactive and Biocompatible Polymers, vol. 24, pp. 235-247, 2009.
Leonor I. B., Balas F., Kawashita M., Reis R. L., Kokubo T., and Nakamura T.,
"Biomimetic apatite deposition on polymeric microspheres treated with a calcium silicate solution",
Journal of Biomedical Materials Research part B , vol. 91B, issue 1, pp. 239-247, doi:
10.1002/jbm.b.31395, 2009.
Leonor I. B., Alves C. M., Azevedo H. S., and Reis R. L.,
"Effects of protein incorporation on calcium phosphate coating",
Materials Science and Engineering C: Materials for biological applications, vol. 29, issue 3, pp. 913-918, doi:
10.1016/j.msec.2008.08.003, 2009.
Pereira R. C., Scaranari M., Castagnola P., Grandizio M., Azevedo H. S., Reis R. L., Cancedda R., and Gentili C.,
"Novel injectable gel (system) as a vehicle for human articular chondrocytes in cartilage tissue regeneration",
Journal of Tissue Engineering and Regenerative Medicine, vol. 3;Issue2, pp. 97-106, 2009.
Martins A. M., Pham Q. P., Malafaya P. B., Sousa R. A., Gomes M. E., Raphael R. M., Kasper F. K., Reis R. L., and Mikos A. G.,
"The role of lipase and alpha-amylase in both the degradation of starch/poly(epsilon-caprolactone) fiber meshes and the osteogenic differentiation of cultured marrow stromal cells",
Tissue Engineering: Part A, vol. 15, issue 2, pp. 295-305, 2009.
Caridade S. G., da Silva R. M. P., Reis R. L., and Mano J. F.,
"Effect of Solvent-Dependent Viscoelastic Properties of Chitosan Membranes on the Permeation of 2-Phenylethanol",
Carbohydrate Polymers, vol. 75, issue 4, pp. 651-659, doi:
10.1016/j.carbpol.2008.09.011, 2009.
Bessa P. C., Cerqueira M. T., Rada T., Gomes M. E., Neves N. M., Nobre A., Reis R. L., and Casal M.,
"Expression, purification and osteogenic bioactivity of recombinant human BMP-4, -9, -10, -11 and -14",
Protein Expression and Purification, vol. 63, pp. 89-94, 2009.
da Silva R. M. P., Lopez-Perez P. M., Elvira C., Mano J. F., SanRoman J., and Reis R. L.,
"Poly(N-isopropylacrylamide) surface grafted chitosan membranes as a new substrate for cell sheet engineering and manipulation",
Biotechnology and Bioengineering
, vol. 101, issue 6, pp. 1321-1331, 2008.
Mrugala D., Bony C., Neves N. M., Caillot L., Fabre S., Moukoko D., Jorgensen C., and Noel D.,
"Phenotypic and functional characterisation of ovine mesenchymal stem cells: application to a cartilage defect model",
Annals of the Rheumatic Diseases, vol. 67, issue 3, pp. 288-295, 2008.
Oliveira J. M., Sousa R. A., Kotobuki N., Tadokoro M., Hirose M., Mano J. F., Reis R. L., and Ohgushi H.,
"The Osteogenic Differentiation of Rat Bone Marrow Stromal Cells Cultured With Dexamethasone-loaded Carboxymethylchitosan/Poly(amidoamine) Dendrimer Nanoparticles",
Biomaterials, vol. 30, issue 5, pp. 804-813, 2008.
Santo V. E., Prieto S., Testera A. M., Alonso M., Arias F. J., Mano J. F., and Rodríguez-Cabello J. C.,
"Physical Properties of an Artificial Extracellular Matrix Based on a Crosslinked Elastin-like Polymer",
Materials Science Forum, vol. 587-588, pp. 47-51, 2008.
Bessa P. C., Balmayor E. R., Cerqueira M. T., Rada T., Gomes M. E., Neves N. M., Azevedo H. S., Casal M., and Reis R. L.,
"Silk nanoparticles for delivery of human BMP-2 in bone regenerative medicine applications",
Tissue Engineering Part A, vol. 14, issue 5, pp. 776-777, 2008.
Balmayor E. R., Bessa P. C., Tuzlakoglu K., Azevedo H. S., Casal M., and Reis R. L.,
"Novel biodegradable polymeric microparticles for the localized delivery of differentiation agents in bone tissue engineering applications",
Tissue Engineering Part A, vol. 14, issue 5, pp. 762-763, 2008.
Balmayor E. R., Tuzlakoglu K., Marques A. P., Azevedo H. S., and Reis R. L.,
"A novel enzymatically-mediated drug delivery carrier for bone tissue engineering applications: combining biodegradable starch-based microparticles and differentiation agents",
Journal of Materials Science-Materials in Medicine, vol. 19, issue 4, pp. 1617-1623, 2008.
da Silva R. M. P., Caridade S. G., SanRamon J., Mano J. F., and Reis R. L.,
"Transport of small anionic and neutral solutes through chitosan membranes: Dependence on cross-linking and chelation of divalent cations",
Biomacromolecules , vol. 9, issue 8, pp. 2132-2138, 2008.
Costa-Pinto A. R., Salgado A. J., Correlo V. M., Sol P. C., Bhattacharya M., Charbord P., Reis R. L., and Neves N. M.,
"Adhesion, proliferation, and osteogenic differentiation of a mouse mesenchymal stem cell line (BMC9) seeded on novel melt-based chitosan/polyester 3D porous scaffolds",
Tissue Engineering Part A, vol. 14, issue 6, pp. 1049-1057, 2008.
Pinto A. R., Correlo V. M., Bhattacharya M., Charbord P., Reis R. L., and Neves N. M.,
"Behaviour of human bone marrow mesenchymal stem cells seeded on fiber bonding chitosan polyester based for bone tissue engineering scaffolds",
Tissue Engineering, vol. 12, issue 4, pp. 1019-1019, 2008.
Mano J. F., Sousa R. A., Boesel L. F., Neves N. M., and Reis R. L.,
"Bioinert, biodegradable and injectable polymeric matrix composites for hard tissue replacement: state of the art and recent developments",
Composites Science and Technology, vol. 64, issue 6, pp. 789-817, 2008.
Oliveira J. T., Crawford A., Mundy J. M., Moreira A. R., Gomes M. E., Hatton P. V., and Reis R. L.,
"A cartilage tissue engineering approach combining starch-polycaprolactone fibre mesh scaffolds with bovine articular chondrocytes",
Journal of Materials Science-Materials in Medicine, vol. 18, issue 2, pp. 295-302, 2008.
Lima H., Araujo J. V., Neves N. M., Mano J. F., and Reis R. L.,
"Cell encapsulation in thermoresponsive chitosan based hydrogels for cartilage tissue engineering",
Tissue Engineering Part A, vol. 14, issue 5, pp. 709-710, 2008.
Cruz D. M. G., Ivirico J. L. E., Gomes M. E., Ribelles J. L., Sanchez M. S., Reis R. L., and Mano J. F.,
"Chitosan microparticles as injectable scaffolds for tissue engineering applications",
Tissue Engineering Part A, vol. 14, issue 5, pp. 821-821, 2008.
Ribeiro C. A., Salgado A. J., Fraga J. S., Neves N. M., Gimble J. M., Reis R. L., and Sousa N.,
"A comparative study on the effects of adipose tissue derived and bone marrow mesenchymal stem cells on neurons/glial cells viability, proliferation and differentiation",
Tissue Engineering Part A, vol. 14, issue 5, pp. 800-801, 2008.
Gomes M. E., Reis R. L., Cunha A. M., van Blitterswijk C. A., and deBruijn J. D.,
"Cytocompatibility and response of osteoblastic-like cells to starch-based polymers: effect of several additives and processing conditions",
Biomaterials, vol. 22, issue 13, pp. 1911-1917, 2008.
Ylikauppila H., Nikkola L., Tukiainen M., Gomes M. E., Reis R. L., Kellomäki M., and Ashammakhi N.,
"Development of bioactive glass fiber reinforced starch-polycaprolactone composite",
Cytotherapy, vol. 8, pp. 44-44, 2008.
Bessa P. C., Cerqueira M. T., Rada T., Gomes M. E., Neves N. M., Casal M., and Reis R. L.,
"Expression, purification and bioactivity of recombinant human bone morphogenetic protein-4,-9,-10,-11 and-14 produced in Escherichia coli for tissue engineering applications",
Tissue Engineering Part A, vol. 14, issue 5, pp. 852-852, 2008.
Salgado A. J., Fraga J. S., Neves N. M., Reis R. L., and Sousa N.,
"Human umbilical cord perivascular cells (HUCPVCs) as source of mesenchymal progenitors for central nervous system regenerative medicine: Role of paracrine factors and direct cell-to-cell contacts in neurons/glial cells viability, proliferation and differe",
Tissue Engineering, vol. 13, issue 7, pp. 1707-1707, 2008.
Oliveira J. M., Kotobuki N., Hirose M., Mano J. F., Reis R. L., and Ohgushi H.,
"Intracellular carboxymethylchitosan/poly(amidoamine) nanocarriers loaded with dexamethasone enhances osteogenic differentiation of RBMSCs in vitro",
Tissue Engineering, vol. 13, issue 7, pp. 1719-1719, doi:
10.1089/ten.2007.1501, 2008.
Tuzlakoglu K., Bolgen N., Salgado A. J., Gomes M. E., Piskin E., and Reis R. L.,
"Nano- and micro-fiber combined scaffolds: A new architecture for bone tissue engineering",
Journal of Materials Science-Materials in Medicine, vol. 16, issue 12, pp. 1099-1104, 2008.
Salgado A. J., Sousa R. A., Oliveira J. T., Silva N. A., Neves N. M., Reis R. L., and Sousa N.,
"Novel tissue engineering 3D scaffolds for spinal cord injury based on starch/polycaprolactone blends: Development and preliminary assessment of their biological performance",
Tissue Engineering, vol. 13, issue 7, pp. 1736-1737, 2008.
Salgado A. J., Gomes M. E., Chou A. M., Coutinho O. P., Reis R. L., and Hutmacher D. W.,
"Preliminary study on the adhesion and proliferation of human osteoblasts on starch-based scaffolds",
Materials Science & Engineering C-Biomimetic and Supramolecular Systems, vol. 20, issue 1-2, pp. 27-33, 2008.
Correlo V. M., Boesel L. F., Bhattacharya M., Mano J. F., Neves N. M., and Reis R. L.,
"Properties of melt processed chitosan and aliphatic polyester blends",
Materials Science and Engineering a-Structural Materials Properties Microstructure and Processing, vol. 403, issue 1-2, pp. 57-68, 2008.
Haltpeter, Bevis M. J., Gomes M. E., Cunha A. M., and Reis R. L.,
"Shear controlled orientation in injection moulding of starch based blends intended for medical applications",
Plastics Rubber and Composites, vol. 32, issue 4, pp. 173-181, 2008.
Silva N. A., Salgado A. J., Sousa R. A., Oliveira J. T., Neves N. M., Mano J. F., Sousa N., and Reis R. L.,
"Starch/gellan gum hybrid 3D guidance systems for spinal cord injury regeneration: Scaffolds processing, characterization and biological evaluation",
Tissue Engineering Part A, vol. 14, issue 5, pp. 779-779, 2008.
Gomes M. E., Azevedo H. S., Moreira A. R., Ella V., Kellomäki M., and Reis R. L.,
"Starch-poly(epsilon-caprolactone) and starch-poly(lactic acid) fibre-mesh scaffolds for bone tissue engineering applications: structure, mechanical properties and degradation behaviour",
Journal of Tissue Engineering and Regenerative Medicine, vol. 2, issue 5, pp. 243-252, 2008.
Ella V., Gomes M. E., Reis R. L., Törmälä P., and Kellomäki M.,
"Studies of P(L/D)LA 96/4 non-woven scaffolds and fibres; properties, wettability and cell spreading before and after intrusive treatment methods",
Journal of Materials Science-Materials in Medicine, vol. 18, issue 6, pp. 1253-1261, 2008.
Rodrigues M. T., Gomes M. E., Viegas C. A. A., Azevedo J. T., Dias I. R., and Reis R. L.,
"Tissue-engineered constructs based on SPCL scaffolds cultured with goat marrow cells: functionality in femoral defects",
Tissue Engineering, vol. 13, issue 7, pp. 1713-1713, 2008.
Cruz D. M. G., Ivirico J. L. E., Gomes M. M., Ribelles J. L., Sanchez M. S., Reis R. L., and Mano J. F.,
"Chitosan microparticles as injectable scaffolds for tissue engineering",
Journal of Tissue Engineering and Regenerative Medicine, vol. 2, issue 6, pp. 378-380, 2008.