Title | Adipose Tissue-derived Stem Cells do Not Elicit Alloreactivity After Chondrogenic and Osteogenic Differentiation |
Publication Type | Comunication - Oral |
Year of Publication | 2015 |
Authors | Santos T. C., Rodrigues D. B., Cerqueira M. T., Pirraco R. P., Castro A. G., Reis R. L., and Marques A. P. |
Abstract | Mesenchymal stem cells lack or express low levels of major histocompatibility complex (MHC) class II and other immunoactive co-stimulatory molecules rendering them “immunoincompetent”. We have shown that human adipose tissue-derived stem cells (hASCs) implanted subcutaneously in mice did not elicit adverse immune responses 1. In this study we hypothesised that undifferentiated hASCs, and derived osteoblasts and chondrocytes, are able to evade xenogeneic immune system by failing activating murine bone marrow-derived macrophages (mBMMØs) and dendritic cells (DCs). 1-Santos, TC et al., Tissue Eng A, 19(7-8): 83, 2013. |
Conference Name | TERMIS-World-2015 |
Date Published | 2015-09-08 |
Conference Location | Boston |
DOI | 10.1089/ten.tea.2015.5000.abstracts |
Keywords | Human Adipose tissue-derived stem cells, Immunomodulation, Murine Dendritic Cells, Murine Macrophages, Tissue Engineering & Regenerative Medicine, Xenogenic Approach |
Rights | openAccess |
Peer reviewed | no |
Status | published |