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Patent (70)
Casanova M. R., Casanova C. R., Maia F. R., Moreira S. P., Reis R. L., and Oliveira J. M., "A microfluidic device for liquid sample processing, methods of production and uses thereof ", International patent application PCT/EP2025/084811, filed on 28/11/2025, priority date 28/11/2024, 2025.
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Caballero D., Reis R. L., Lima A. C., Neves N. M., and Oliveira J. M., "MICROFLUIDIC DEVICE FOR PARTICLES OR BIOMOLECULES ISOLATION, METHODS, AND USES THEREOF", P1606.4 PP, 2025.
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Casanova M. R., Casanova C. R., Maia F. R., Reis R. L., and Oliveira J. M., "A microfluidic chip for capture of biological and non-biological entities, methods of production and uses thereof", PORTUGAL. National Institute of Industrial Property – INPI. Provisional application no. 119865, filed on Nov. 28, 2024, 2024.
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Casanova M. R., Martins A., Mota P., Reis R. L., Neves N. M., Dias E. C., and Barros A., "Polimeric substrates for nerve regeneration, methods and uses thereof", International patent application PCT/IB2021/06131 filling date 03/12/2021, publication of WO2022118282A1 at 09/06/2022 , 2022.
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Ribeiro V. P., Oliveira J. M., Silva-Correia J., and Reis R. L., "CARBONIC ANHIDRASE-IMMOBILIZING SILK HYDROGELS, METHODS OF PRODUCTION AND USES THEREOF", WO 2022/029739 A1, 2022.
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Pina S., Fernandes E., Rebelo R., Lobo F. C. M., Silva T. H., Correlo V. M., Oliveira J. M., and Reis R. L., Ceramic-based composite materials methods and used thereof , 2021.
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Pina S., Fernandes E. M., Rebelo R., Lobo F. C. M., Silva T. H., Correlo V. M., Oliveira J. M., and Reis R. L., "Ceramic-based composite materials methods and used thereof", Patent No. PCT/IB2021/050378, WO2021148938A1, 2021.
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Rodrigues D. B., Moreira H. R., Gasperini L., Cerqueira M. T., Marques A. P., Pirraco R. P., and Reis R. L., "HYDROGEL-LIKE PARTICLES, METHODS ANS USES THEREOF", WO/2021/064678, 2021.
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Casanova M. R., Martins A., Mota P., Reis R. L., and Neves N. M., "Polymeric substrates for nerve regeneration, methods and uses thereof", Priority national patent application nr. 116970, priority date 03/12/2020, 2020.
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Carvalho M. R., Caballero D., Carvalho C. R., Costa J. B., Ribeiro V. P., Oliveira J. M., Kundu S. C., and Reis R. L., "ENZYMATICALLY CROSSLINKED SILK FIBROIN HYDROGEL MICROFLUIDIC PLATFORM, METHODS OF PRODUCTION AND USES THEREOF", WO/2021/038507, 2019.
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Canadas R. F., Oliveira J. M., Marques A. P., and Reis R. L., "Method for distribution of active factors in an artificial tissue, products and uses thereof, deposited application", 20191000020432, 2019.
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Gonçalves C., Silva S. S., Maia F. R., Radhouani H., Oliveira J. M., and Reis R. L., "SUCROSE ACETATE ISOBUTYRATE-BASED COMPOSITIONS, METHODS AND USES THEREOF", WO/2018/225050, 2018.
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Carvalho C. R., Costa J. B., Ribeiro V. P., Silva-Correia J., Oliveira J. M., and Reis R. L., "Nerve guidance conduits derived from silk fibroin hydrogels: methods of production and uses thereof", WO/2018/025186 (Priority date: 109562 01.08.2016 PT), 2018.
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Rodrigues D. B., Santos T. C., Oliveira J. M. A., and Reis R. L., "DENDRIMER-DERIVED ARTIFICIAL ANTIGEN PRESENTATION, METHODS AND USES THEREOF", PCT/IB2017/053596, 2017.
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Oliveira J. M., Vieira S., Oliveira E., Silva-Correia J., Reis R. L., Walczak P., Malysz-Cymborska I., Golubczyk D., Kalkowski L., Majchrzak M., Janowski M., Strymecka P., Stanaszek L., Lukomska B., Svendsen T., Asdahl L. C., and Sætrang H. E. M., "Hydrogel Comprising Manganese, Methods and Uses Thereof", EP17209876.6, Priority date: 21.12.2017, 2017.
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Martins A., Alves da Silva M. L., Reis R. L., and Neves N. M., "Polymeric mesh with selective permeability, for the repair and regeneration of tissues. ", EP 2878314 B1, App nr. EP20130783091, Priority date: 27/07/2012, 2017.
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Mendes B. B., Domingues R. M. A., Babo P. S., Reis R. L., and Gomes M. E., "Blood derivatives composite material, methods of production and uses thereof.", International Application: PCT/IB2017/056699. Provisional patent No.109701. , 2017.
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Gasperini L., Marques A. P., and Reis R. L., "FIBERS WITH SEGMENTS, THEIR PREPARATION AND APPLICATIONS THEREOF", PCT/IB2017/056654, 2017.
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López-Cebral R., Novoa-Carballal R., Oliveira J. M., Silva T. H., and Reis R. L., High molecular weight chitosan, process for obtaining and uses thereof , 2017.
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Radhouani H., Gonçalves C., Oliveira J. M., and Reis R. L., "Kefiran for use in regenerative medicine and/or tissue engineering", WO/2018/042405, 2017.
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Costa J. B., Silva-Correia J., Oliveira J. M., and Reis R. L., "INKS FOR 3D PRINTING, METHODS OF PRODUCTION AND USES THEREOF", WO/2018/225049, Priority date: 10136 09.06.2017 PT, 2017.
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Vieira S., Silva-Correia J., Oliveira J. M., and Reis R. L., "Composition Comprising Polyeletrolyte Complexes, Methods and Uses Thereof", WO/2017/089974, 2017.
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Pina S., Ribeiro V. P., Oliveira J. M., and Reis R. L., "Ionic-doped composition methods and uses thereof", WO2018215997, 2017.
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Castro V. I. B., Silva J. M., Craveiro R., Reis R. L., Paiva A., and Duarte A. R. C., "Cryoprotectant and/or cryopreservants composition, methods and uses tereof", Patenten number:17179887.9-1454, 2017.
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Martins A., Oliveira C., Reis R. L., and Neves N. M., "Polymeric substrates with immobilized antibodies and method of production thereof. ", App nr. US 2017/0051050 A1, Priority date: 28/04/2014, 2017.
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Mendes B. B., Domingues R. M. A., Babo P. S., Reis R. L., and Gomes M. E., "Platelet lysate/Cellulose nanocrystals nanocomposite materials, methods of production and uses thereof.", Provisional patent No.109701., 2016.
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Canadas R. F., Oliveira J. M., Marques A. P., and Reis R. L., Multi-chambers bioreactor, methods and uses , 2016.
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Barros, A. A., Oliveira C., Lima E., Reis R. L., and Duarte A. R. C., "Biodegradable ureteral stents: new approach for urothelial tumors of upper urinary tract cancer", 109229, 2016.
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Martins A., Alves da Silva M. L., Reis R. L., and Neves N. M., "Polymeric mesh with selective permeability, for the repair and regeneration of tissues. ", App nr. US 2016/0038645 A1, Priority date: 27/07/2012 , 2016.
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Sousa R. A., Gertrudes A., Correia C., da Silva Morais A., Gonçalves C., Radhouani H., Vilela C. A., Santos T. C., Oliveira J. M., Espregueira-Mendes J. D., and Reis R. L., "Viscosupplement composition comprising ulvan for treating arthritis", WO/2015/174872, 2015.
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Martins A., Oliveira C., Reis R. L., and Neves N. M., "Polymeric substrates with immobilized antibodies and method of production thereof. ", WO/2015/166414, App nr. PCT/IB2015/053091, Priority date: 28/04/2014, 2015.
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Barros, A. A., Oliveira C., Reis R. L., Lima E., and Duarte A. R. C., "A composition for ureteral stent and the method thereof", 15169249.8, 2015.
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Moreira-Silva J., Diogo G. S., Prata M. B., Silva T. H., Marques A. P., and Reis R. L., "Marine-sponge type IV collagen membranes its production and biomedical applications thereof", patent application nº PCT/IB2015/054324, published as WO/2015/186118, 2015.
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Reis R. L., Duarte A. R. C., Mano J. F., Silva T. H., Aroso I. M., Barros, A. A., and Silva J. C., "Method to obtain collagen/gelatin from marine sponges", patent application nº PCT/IB2015/052370, published as WO/2015/151030 and EP3126382; priority date: 2014-03-31, 2015.
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Barros, A. A., Aroso I. M., Mano J. F., Duarte A. R. C., and Reis R. L., "Method to obtain collagen/gelatin from marine sponges", WO2015151030A1, 2015.
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Oliveira S. M., Reis R. L., and Mano J. F., "CELL-INSTRUCTING COMPOSITIONS COMPRISING PLATELET DERIVATIVES", PCT/IB2015/053870 , 2015.
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Reis R. L., Duarte A. R. C., Paiva A., Craveiro R., Aroso I. M., and Martins M., Processo de Produção de Estruturas Tridimensionais Porosas para Aplicações Farmacêuticas e/ou Biomédicas utilizando Solventes Eutectivos e Tecnologia Supercritica , 2015.
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Oliveira J. T., Sousa R. A., and Reis R. L., "Gellan gum based hydrogels for regenerative medicine and tissue engineering applications, its system, and processing devices", WO/2009/101518, Priority date: 103970 15.02.2008 PT., 2014.
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da Silva L. P., Cerqueira M. T., Sousa R. A., Marques A. P., Correlo V. M., and Reis R. L., Gellan gum‐based spongylike hydrogels: methods and biomedical applications thereof. , 2014.
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Canadas R. F., Oliveira J. M., Marques A. P., and Reis R. L., "Rotational dual chamber bioreactor: methods and uses thereof", Canadas RF, Oliveira JM, Marques AP, Reis RL, Rotational dual chamber bioreactor: methods and uses thereof, patent PCT/IB2014/059740, 2014, 2014.
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Reis R. L., Sousa R. A., Correia C., Vilela C. A., da Silva Morais A., Gertrudes A., Oliveira J. M., Santos T. C., and Espregueira-Mendes J. D., "PRODUCTS FOR REPAIRING CARTILAGE LESIONS, METHOD OF PREPARATION AND USES THEREOF", Nº: 107642 H, 2014.
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Martins A., Alves da Silva M. L., Reis R. L., and Neves N. M., "Polymeric mesh with selective permeability, for the repair and regeneration of tissues. ", WO/2014/016816, App nr. PCT/IB2013/056218, Priority date: 27/07/2012, 2014.
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Reis R. L., Mano J. F., Gomes M. E., Duarte A. R. C., and Santo V. E., "Método de preparação de estruturas tridimensionais à base de lisados de plaquetas processados por tecnologia supercritica", PT106220 (A), 2013.
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Silva-Correia J., Oliveira J. M., Oliveira J. T., Sousa R. A., and Reis R. L., "Photo-crosslinked Gellan gum-based hydrogels: methods and uses thereof", WO2011/119059, Priority date: 105030 26.03.2010 PT, 2013.
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Oliveira J. M., Pereira H., Yan L. P., Silva-Correia J., Oliveira A. L., Espregueira-Mendes J. D., and Reis R. L., "Scaffold that enables segmental vascularization for the engineering of complex tissue and methods of making the same", Patent number PT 106174, Priority date: 24.02.2012, 2013.
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Costa P. F., Martins A., Vaquette C., Neves N. M., Gomes M. E., Hutmacher D. W., Reis R. L., and Melchels F. P. W., "Bioreactor composed of watertight chamber and internal matrix for the generation of cellularized medical implants. ", WO/2013/103306 A1, App nr. PCT/PT2013/000001, Priority date: 05/01/2012, 2013.
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Costa P. F., Martins A., Vaquette C., Neves N. M., Gomes M. E., Hutmacher D. W., and Reis R. L., "Single-step method and device for the generation of stratified tubular tissue substitutes.", WO2013085404A1, App nr. PCT/PT2012/000047, Priority date: 07/12/2011 , 2013.
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Baran E. T., Mendes A. C., Azevedo H. S., and Reis R. L., "Device, method and system for preparing microcapsules", PT105489 (A); PT105489 (B), 2013.
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Costa P. F., Martins A., Vaquette C., Neves N. M., Gomes M. E., Hutmacher D. W., and Reis R. L., "Single-step method and device for the generation of stratified tubular tissue substitutes", EP2788469 (A1) 2014-10-15 , 2013.
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Barros, A. A., Duarte A. R. C., Pires R. A., Lima E., Mano J. F., and Reis R. L., "Cateteres à base de polímeros de origem natural produzidos utilizando tecnologias limpas", PT patent application nº 20121000079210, 2012.
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Costa P. F., Martins A., Vaquette C., Neves N. M., Gomes M. E., Hutmacher D. W., Reis R. L., and Melchels F. P. W., "Bioreactor composed of watertight chamber and internal matrix for the generation of cellularized medical implants", EP2800807 (A1) 2014-11-12 , 2012.
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Costa P. F., Martins A., Vaquette C., Neves N. M., Gomes M. E., Hutmacher D. W., Reis R. L., and Melchels F. P. W., "Bioreactor composed of watertight chamber and internal matrix for the generation of cellularized medical implants", PT106083 (A) 2013-07-05 , 2012.
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Reis R. L., Yan L. P., Oliveira A. L., Oliveira J. M., Pereira D. R., Correia C., and Sousa R. A., "Hidrogéis derivados da fibroína da seda: métodos e respectivas aplicações", PT107426 (A); PT107426 (B), 2011.
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Yan L. P., Oliveira A. L., Pereira D. R., Correia C., Sousa R. A., and Reis R. L., "Hidrogéis derivados da fibroína da seda: métodos e respectivas aplicações", PT106041 (A) 2013-06-06, 2011.
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Reis R. L., Gomes M. E., Neves N. M., Martins A., Vaquette C., and Hutmacher D. W., "Single-step method and device for the generation of stratified tubular tissue substitutes", PT106046 (A) 2013-06-07 , 2011.
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Alves A., Sousa R. A., and Reis R. L., "Processamento e aplicação industrial de polissacáridos de algas verdes", PT104370 (B); PT104370 (A), 2011.
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Fernandes E. M., Correlo V. M., Chagas J. A., and Reis R. L., "Fibre-Reinforced cork-based composites", WO 2011014085 (A2), WO 2011014085 (A3), Amorim Revestimentos S.A., 2011.
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Mano J. F., Neto A. I., Custódio C. A., Song W., and Oliveira M. B., "process for the deposition of biomaterials on water repellent substrates and resulting biomaterials", PT105960 (A) 2012-08-16, 2010.
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Costa P. F., Martins A., Gomes M. E., Neves N. M., and Reis R. L., "Multichamber bioreactor with bidirectional perfusion integrated in a culture system for tissue engineering strategies", EP2151491B1, App Nr. EP20090009863, Priority date 2008-08-06, 2010.
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Silva L., Cerqueira M. T., Sousa R. A., Correlo V. M., Marques A. P., and Reis R. L., "Gellan gum spongy-like hydrogel, its preparation and biomedical applications thereof", WO2014167513 (A1), 2010.
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Oliveira J. T., Reis R. L., and Sousa R. A., "Misturas à base de hidrogéis de goma gelana para regeneração de tecido adiposo", PT104904 (A) 2011-06-21 , 2009.
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Fernandes E. M., Correlo V. M., Chagas J. A., and Reis R. L., "Cork-Polymer composite (CPC) materials and processes to obtain the same", WO2009072914 (A1), Amorim Revestimentos S.A., 2009.
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Oliveira J. T., Pedro A. J., and Reis R. L., "Dynamic systems for culturing cells in 3d supports", WO/2009/087448, Priority date: 20.12.2007 PT103906 (A, 2009.
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Fernandes E. M., Correlo V. M., Chagas J. A., and Reis R. L., "Compósitos à base de cortiça reforçados com fibras", PT 104704, Amorim Revestimentos S.A., Granted, 2009.
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Mano J. F., and Song W., "Método para fabricar partículas de base polimérica ou de hidrogel utilizando substratos repelentes a líquidos", T104690 (A) 2011-04-06 PT104690 (B) 2012-05-15, 2009.
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Oliveira J. T., Reis R. L., Veiga D. D., and Sousa R. A., "Estruturas compósitas à base de goma gelana para utilização em medicina regenerativa e seus métodos de preparação", PT104674 (A) 2011-01-17, 2009.
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Gomes M. E., Reis R. L., and Gardel L., "Bi-directional continuous perfusion bioreactor for tridimensional culture op mammal tissue substitutes", PT104278 (A) 2010-06-04, 2008.
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Pereira H., Reis R. L., Silva S. P., and Marques A. V., "Process of cork pre-expansion by submission to microwave radiation and resulting product thereof ", WO2008115086 (A1); 2008-09-25 , 2008.
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Rada T., Gomes M. E., and Reis R. L., "Método para obtenção de células estaminais adultas a partir de tecido adiposo", PT104164 (A) 2010-03-01 , 2008.
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Fernandes E. M., Correlo V. M., Chagas J. A., and Reis R. L., "Grânulos compósitos de cortiça com polímero (CPC) e processos para obtenção dos mesmos. ", PT 103898, Amorim Revestimentos S.A., Granted, 2007.
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