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Patent
2005
Santos T. C.
,
Marques A. P.
,
Correlo V. M.
,
Bhattacharya M.
,
Neves N. M.
,
Castro A. G.
, and
Reis R. L.
,
"
Novel melt-processed chitosan-polyester blends for orthopaedic applications and its interactions with osteoblast-like cells
",
6th International Symposium on Frontiers in Biomedical Polymers
, 2005.
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2006
Santos T. C.
,
Marques A. P.
,
Silva S. S.
,
Oliveira J. M.
,
Mano J. F.
,
Castro A. G.
, and
Reis R. L.
,
"
In vitro
evaluation of the behaviour of polymorphonuclear neutrophils in direct contact with chitosan-based membranes
",
6th European Symposium on Biochemical Engineering Science
, 2006.
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2007
Oliveira J. T.
,
Malafaya P. B.
,
Sousa R. A.
,
Santos T. C.
,
Marques A. P.
,
Martins L.
,
Pinto L. G.
,
Fernandes R.
,
Castro A. G.
,
Mano J. F.
,
Neves N. M.
, and
Reis R. L.
,
"
GELLAN GUM HYDROGELS AS SUPPORTS FOR CARTILAGE TISSUE ENGINEERING APPROACHES: IN VITRO AND IN VIVO EVALUATION
",
4th Marie Curie Cutting Edge Conference Biocompatibility evaluation and biological behaviour of polymeric biomaterials, 9-13 October 2007, Alvor, Algarve, Portugal
, 2007.
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Santos T. C.
,
Tuzlakoglu K.
,
Morton T.
,
Lang K.
,
Reise K.
,
Marques A. P.
,
Castro A. G.
,
Redl H.
,
Reis R. L.
, and
van Griensven M.
,
"
In vivo
evaluation of the suitability of starch-based scaffolds for bone tissue engineering constructs using Adipose Derived Adult Stem Cells and transgenic mice
",
Society for Biomaterials 2007
, 2007.
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Santos T. C.
,
Hoering B.
,
Marques A. P.
,
Castro A. G.
,
Redl H.
,
van Griensven M.
, and
Reis R. L.
,
"
In Vivo
Performance of Starch-based Scaffolds: Assessment of the Inflammatory Response
",
TERMIS NA 2007
, 2007.
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Santos T. C.
,
Hoering B.
,
Marques A. P.
,
Castro A. G.
,
Redl H.
,
van Griensven M.
, and
Reis R. L.
,
"
In Vivo Assessment of the Inflammatory Response of Starch-based Scaffolds
",
4th Marie Curie Cutting Edge Conference Biocompatibility evaluation and biological behaviour of polymeric biomaterials, 9-13 October 2007, Alvor, Algarve, Portugal
, 2007.
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Santos T. C.
,
Tuzlakoglu K.
,
Morton T.
,
Lang K.
,
Reise K.
,
Marques A. P.
,
Castro A. G.
,
Redl H.
,
Reis R. L.
, and
van Griensven M.
,
"
In vivo evaluation of the suitability of starch-based scaffolds for bone tissue engineering constructs using Adipose Derived Adult Stem Cells and transgenic mice
",
4th Marie Curie Cutting Edge Conference Biocompatibility evaluation and biological behaviour of polymeric biomaterials
, 2007.
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Santos T. C.
,
Marques A. P.
,
Silva S. S.
,
Oliveira J. M.
,
Mano J. F.
,
Castro A. G.
, and
Reis R. L.
,
"
In vitro evaluation of the behaviour of human polymorphonuclear neutrophils in direct contact with chitosan-based membranes
",
Journal of Biotechnology
, vol. 132, issue 2, pp. 218-226, 2007.
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2008
Oliveira J. T.
,
Picchioci R.
,
Santos T. C.
,
Malafaya P. B.
,
Sousa R. A.
,
Castro A. G.
,
Mano J. F.
,
Neves N. M.
, and
Reis R. L.
,
"
Injectable Gellan Gum Hydrogels as Supports for Cartilage Tissue Engineering Applications: In vitro characterization and initial In vivo studies
",
8th World Biomaterials Congress
, 2008.
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Mano J. F.
,
Silva G. A.
,
Azevedo H. S.
,
Malafaya P. B.
,
Sousa R. A.
,
Silva S. S.
,
Boesel L. F.
,
Oliveira J. M.
,
Santos T. C.
,
Marques A. P.
,
Neves N. M.
, and
Reis R. L.
,
"
Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends
",
Journal of the Royal Society Interface
, vol. 4, issue 17, pp. 999-1030, 2008.
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Oliveira J. T.
,
Picciochi R.
,
Santos T. C.
,
Martins L.
,
Pinto L. G.
,
Malafaya P. B.
,
Sousa R. A.
,
Marques A. P.
,
Castro A. G.
,
Mano J. F.
,
Neves N. M.
, and
Reis R. L.
,
"
Injectable gellan gum hydrogels as supports for cartilage tissue engineering applications
",
Tissue Engineering Part A
, vol. 14, issue 5, pp. 748-748., 2008.
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RepositoriUM
Malafaya P. B.
,
Oliveira J. T.
,
Santos T. C.
,
van Griensven M.
, and
Reis R. L.
,
"
Morphometric and mechanical characterization, insulin loading and in-vivo biocompatibility of chitosan particles aggregated scaffolds for tissue engineering
",
Tissue Engineering: Part A
, vol. 14, issue 5, pp. 757, 2008.
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Malafaya P. B.
,
Santos T. C.
,
van Griensven M.
, and
Reis R. L.
,
"
Morphology, mechanical characterization and in vivo neo-vascularization of chitosan particle aggregated scaffolds architectures
",
Biomaterials
, vol. 29, pp. 3914-3926, 2008.
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Azevedo H. S.
,
Santos T. C.
, and
Reis R. L.
,
"
Controlling the Degradation of Natural Polymers for Biomedical Applications
",
Natural-based Polymers for Biomedical Applications
,
Woodhead Publishing Limited
,
Cambridge
, pp. 106-128, 2008.
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Santos T. C.
,
Marques A. P.
, and
Reis R. L.
,
"
In vivo tissue responses to natural-origin biomaterials
",
Natural-based polymers for biomedical applications
,
Woodhead Publishing in Materials
,
Cambridge
, pp. 683-698, 2008.
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Malafaya P. B.
,
Santos T. C.
,
van Griensven M.
, and
Reis R. L.
,
"
Chitosan particle aggregated architectures for osteochondral tissue engineering: development and characterization of polymeric and bilayered scaffolds
",
2008 Annual Conference of Tissue Engineering and Regenerative Medicine International Society – Asian Pacific Region (TERMIS-AP 2008)
, 2008.
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Santos T. C.
,
Morton T.
,
Reise K.
,
Marques A. P.
,
Castro A. G.
,
Redl H.
,
van Griensven M.
, and
Reis R. L.
,
"
ADIPOSE STEM CELLS AND STARCH-BASED CONSTRUCTS PERFORMANCE ON VEGFR2-LUC TRANSGENIC MICE
",
3rd International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
, 2008.
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Marques A. P.
,
Santos T. C.
,
da Silva R. M. P.
,
Silva S. S.
,
Oliveira J. M.
,
van Griensven M.
,
Mano J. F.
,
Redl H.
, and
Reis R. L.
,
"
Chitosan improves the in vivo biological response to soy-based biomaterials
",
Translational Biomaterial Research Symposium
, 2008.
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Marques A. P.
,
Santos T. C.
,
da Silva R. M. P.
,
Silva S. S.
,
Oliveira J. M.
,
van Griensven M.
,
Mano J. F.
,
Redl H.
, and
Reis R. L.
,
"
Chitosan improves the in vivo biological response to soy-based biomaterials
",
Society for biomaterials-Advancing disoveries from the laboratory to the clinic
, 2008.
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Santos T. C.
,
Marques A. P.
,
Silva S. S.
,
Oliveira J. M.
,
Mano J. F.
,
Castro A. G.
,
van Griensven M.
,
Redl H.
, and
Reis R. L.
,
"
Chitosan/soy-based membranes enhance wound reepithelialization in partial thickness skin wounds
",
TERMIS-EU 2008 Meeting, Porto, PT, Tissue Engineering (2008)
, 2008.
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Santos T. C.
,
Tuzlakoglu K.
,
Morton T.
,
Reise K.
,
Marques A. P.
,
Castro A. G.
,
Redl H.
,
Reis R. L.
, and
van Griensven M.
,
"
In vivo evaluation of the suitability of starch-based scaffolds for bone tissue engineering constructs using Adipose Derived Adult Stem Cells and transgenic mice
",
World Biomaterials Congress - 2008
, 2008.
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Oliveira J. T.
,
Picchioci R.
,
Santos T. C.
,
Martins L.
,
Pinto L. G.
,
Malafaya P. B.
,
Sousa R. A.
,
Marques A. P.
,
Castro A. G.
,
Mano J. F.
,
Neves N. M.
, and
Reis R. L.
,
"
Injectable Gellan Gum Hydrogels as Supports for Cartilage Tissue Engineering Applications
",
Tissue Engineering and Regenerative Medicine International Society (TERMIS) TERMIS-EU Porto Meeting 2008
, 2008.
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Santos T. C.
,
Marques A. P.
,
Castro A. G.
,
van Griensven M.
,
Redl H.
, and
Reis R. L.
,
"
Long term in vivo performance of starch-based scaffolds
",
TERMIS-EU 2008 Meeting, Porto, PT, Tissue Engineering (2008)
, 2008.
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Santos T. C.
,
Morton T.
,
Reise K.
,
Marques A. P.
,
Castro A. G.
,
Redl H.
,
van Griensven M.
, and
Reis R. L.
,
"
Adipose stem cells and starch-based constructs performance on VEGFR2-LUC transgenic mice
",
3rd Annual International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
, 2008.
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2009
Santos T. C.
,
Hoering B.
,
Marques A. P.
,
Castro A. G.
,
Redl H.
,
van Griensven M.
, and
Reis R. L.
,
"
Different implantation models for biomaterials host response evaluation
",
1st SPCAL Meeting
, 2009.
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2010
Oliveira J. T.
,
Santos T. C.
,
Martins L.
,
Picciochi R.
,
Marques A. P.
,
Castro A. G.
,
Neves N. M.
,
Mano J. F.
, and
Reis R. L.
,
"
Gellan Gum Injectable Hydrogels for Cartilage Tissue Engineering Applications:In Vitro Studies and Preliminary In Vivo Evaluation
",
Tissue Engineering Part A
, vol. 16, issue 1, pp. 343-353, 2010.
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Oliveira J. T.
,
Santos T. C.
,
Martins L.
,
Alves da Silva, ML
,
Marques A. P.
,
Castro A. G.
,
Neves N. M.
, and
Reis R. L.
,
"
Performance of new gellan gum hydrogelscombined with human articular chondrocytesfor cartilage regeneration when subcutaneouslyimplanted in nude mice
",
Journal of Tissue Engineering and Regenerative Medicine
, vol. 3, issue 7, pp. 493-500, 2010.
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Santos T. C.
, and
Reis R. L.
,
"
Host Reaction in Tissue Engineering
",
XI Jornadas de Biologia Aplicada
, 2010.
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Santos T. C.
,
Marques A. P.
,
Silva S. S.
,
Oliveira J. M.
,
Mano J. F.
,
Castro A. G.
,
van Griensven M.
, and
Reis R. L.
,
"
Chitosan improves the biological performance of soy-based biomaterials
",
Tissue Engineering
, vol. 16, issue 9, pp. 2883-2890, 2010.
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Santos T. C.
,
Marques A. P.
,
Hoering B.
,
Martins A. R.
,
Tuzlakoglu K.
,
Castro A. G.
,
van Griensven M.
, and
Reis R. L.
,
"
In vivo short and long term host reaction to starch-based scaffolds
",
Acta Biomaterialia
, vol. 6, pp. 4314-4326, 2010.
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Silva S. S.
,
Santos T. C.
,
Marques A. P.
,
Mano J. F.
, and
Reis R. L.
,
"
Processing of new chitosan/silk hydrogels using ionic liquids to improve the healing of chronic wounds
",
TERMIS-EU
, 2010.
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Santos T. C.
,
Marques A. P.
,
van Griensven M.
, and
Reis R. L.
,
"
Starch-based Scaffolds for Bone Tissue Engineering: Host Reaction anf Functionality
",
Final EXPERTISSUES Scientific Meeting
, 2010.
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2011
Rada T.
,
Santos T. C.
,
Marques A. P.
,
Correlo V. M.
,
Frias A. M.
,
Castro A. G.
,
Neves N. M.
,
Gomes M. E.
, and
Reis R. L.
,
"
Osteogenic differentiation of two distinct subpopulations of human adipose-derived stem cells: an in vitro and in vivo study
",
Journal of Tissue Engineering and Regenerative Medicine, DOI: 10.1002/term.388
, vol. 6, pp. 1–11, 2011.
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Rada T.
,
Oliveira J. T.
,
Santos T. C.
,
Castro A. G.
,
Reis R. L.
, and
Gomes M. E.
,
"
Chondrogenic Differentiation of hASC sub-population in a nude mice model
",
Current Stem Cell Research & Therapy
, 2011.
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Pirraco R. P.
,
Ferreira B. M.
,
Santos T. C.
,
Frias A. M.
,
Marques A. P.
, and
Reis R. L.
,
"
Endothelial Progenitors Are Sustained by Osteoblasts Monolayers
",
24th European Conference on Biomaterials ESB 2011
, 2011.
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Silva S. S.
,
Duarte A. R. C.
,
Santos T. C.
,
Cerqueira M. T.
,
Marques A. P.
,
Oliveira J. M.
,
Mano J. F.
, and
Reis R. L.
,
"
Integrated strategy using ionic liquids for the design and processability of natural polymeric architectures for regenerative medicine
",
Histology and Histopathology
, vol. 26, issue S1, pp. 272, 2011.
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Santos T. C.
,
Martins A. R.
,
Frias A. M.
,
Marques A. P.
, and
Reis R. L.
,
"
Dendritic cells as relevant tools to predict the outcome of tissue engineering constructs
",
4th Joint ESAO-IFAO Congress
, 2011.
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Santos T. C.
,
Marques A. P.
,
Castro A. G.
,
van Griensven M.
, and
Reis R. L.
,
"
Host response to biomaterials evaluated through different implantation models
",
4th Joint ESAO-IFAO Congress
, 2011.
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2012
Mendes L. F.
,
Pirraco R. P.
,
Szymczyk W.
,
Santos T. C.
,
Frias A. M.
,
Reis R. L.
, and
Marques A. P.
,
"
Pericytes and endothelial cells contribute to the in vivo vascularization of osteogenic tissue formed after cell sheet transplantation
",
7th Annual International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
, 2012.
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Santos T. C.
, and
Reis R. L.
,
"
Animal Experimentation in Tissue Engineering and Regenerative Medicine
",
II SPCAL Meeting
, 2012.
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Mendes L. F.
,
Pirraco R. P.
,
Szymczyk W.
,
Frias A. M.
,
Santos T. C.
,
Reis R. L.
, and
Marques A. P.
,
"
Perivascular-Like Cells Contribute to the Stability of the Vascular Network of Osteogenic Tissue Formed from Cell Sheet-Based Constructs
",
PLoS ONE
, vol. 7, issue 7, pp. e41051, doi:
10.1371/journal.pone.0041051
, 2012.
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RepositoriUM
Mendes L. F.
,
Pirraco R. P.
,
Szymczyk W.
,
Santos T. C.
,
Frias A. M.
,
Reis R. L.
, and
Marques A. P.
,
"
Pericytes contribute to the stability of the vascular network of osteogenic tissue formed from cell sheet-based constructs
",
Journal of Tissue Engineering and Regenerative Medicine
, vol. 6, issue Suppl.1, pp. 311-311, doi:
10.1002/term.1586
, 2012.
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RepositoriUM
Silva S. S.
,
Santos T. C.
,
Cerqueira M. T.
,
Marques A. P.
,
Reys L. L.
,
Silva T. H.
,
Caridade S. G.
,
Mano J. F.
, and
Reis R. L.
,
"
The use of ionic liquids in the processing of chitosan/silk hydrogels for biomedical applications
",
Green Chemistry
, vol. 14, pp. 1463-1470, doi:
10.1039/C2GC16535J
, 2012.
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RepositoriUM
Santos T. C.
,
Cerqueira M. T.
,
Silva A. C.
,
Gama J. B.
,
Rodrigues A. I.
,
Leonor I. B.
,
Marques A. P.
,
Castro A. G.
, and
Reis R. L.
,
"
Immunomodulatory potential of tissue engineered constructs based on human adipose tissue derived stem cells and starch-based scaffolds
",
TERMIS-World 2012 Meeting
, 2012.
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2013
Pirraco R. P.
,
Ferreira B. M.
,
Santos T. C.
,
Frias A. M.
,
Marques A. P.
, and
Reis R. L.
,
"
Adipose stem cell-derived osteoblasts sustain the functionality of endothelial progenitors from the mononuclear fraction of umbilical cord blood
",
Acta Biomaterialia
, vol. 9, issue 2, pp. 5234-5242, doi:
10.1016/j.actbio.2012.09.013
, 2013.
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RepositoriUM
Santos T. C.
,
Hoering B.
,
Reise K.
,
Marques A. P.
,
Silva S. S.
,
Oliveira J. M.
,
Mano J. F.
,
Castro A. G.
,
Reis R. L.
, and
van Griensven M.
,
"
In vivo performance of chitosan/soy-based membranes as wound dressing devices for acute skin wounds
",
Tissue Engineering-A
, vol. 19, issue 7-8, pp. 860-870, doi:
10.1089/ten.TEA.2011.0651
, 2013.
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RepositoriUM
Santos T. C.
,
Morton T.
,
Moritz M.
,
Pfeifer S.
,
Reise K.
,
Marques A. P.
,
Castro A. G.
,
Reis R. L.
, and
van Griensven M.
,
"
VEGF and FGF-2 incorporation in starch-based bone tissue engineering constructs promote the in vivo expression of neovascularisation mediators
",
Tissue Engineering-A
, vol. 19, issue 7-8, pp. 834-848, doi:
DOI: 10.1089/ten.tea.2010.0741
, 2013.
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RepositoriUM
Cerqueira M. T.
,
da Silva L. P.
,
Santos T. C.
,
Pirraco R. P.
,
Martins A. R.
,
Correlo V. M.
,
Marques A. P.
, and
Reis R. L.
,
"
Pre-vascularized gellan gum-hyaluronic acid spongy-like hydrogels improve skin wound healing.
",
Society of Biomaterials Annual Meeting and Exposition
, 2013.
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Rada T.
,
Carvalho P. P.
,
Santos T. C.
,
Castro A. G.
,
Reis R. L.
, and
Gomes M. E.
,
"
Chondrogenic Potential of Two hASCs Subpopulations Loaded onto Gellan Gum Hydrogel Evaluated in a Nude Mice Model
",
Curr Stem Cell Res Ther. 2013 Jun 10. [Epub ahead of print]
, vol. 8, issue 5, pp. 357-364, doi:
10.2174/1574888X113089990049
, 2013.
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RepositoriUM
Cerqueira M. T.
,
Pirraco R. P.
,
Santos T. C.
,
Rodrigues D. B.
,
Frias A. M.
,
Martins A. R.
,
Reis R. L.
, and
Marques A. P.
,
"
Human Adipose Stem Cells Cell Sheet Constructs impact epidermal morphogenesis in full-thickness excisional wounds
",
Biomacromolecules
, vol. 14, issue 11, pp. 3997-4008, doi:
10.1021/bm4011062
, 2013.
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RepositoriUM
Santos T. C.
,
Rodrigues D. B.
,
Cerqueira M. T.
,
Silva A. C.
,
Rodrigues A. I.
,
Leonor I. B.
,
Marques A. P.
,
Castro A. G.
, and
Reis R. L.
,
"
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Human Skin Cell Fractions Fail to Self-Organize Within a Gellan Gum/Hyaluronic Acid Matrix but Positively Influence Early Wound Healing
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Gellan Gum-Hyaluronic Acid Spongy-like hydrogels and cells from adipose tissue synergize promoting neoskin vascularization
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Xenogeneic M2-polarization of Macrophages by Undifferentiated and Differentiated Adipose Tissue-derived Stem Cells
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2015
Santos T. C.
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Adipose Tissue-derived Stem Cells do not Elicit Alloreactivity after Chondrogenic and Osteogenic Differentiation
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Castro A. G.
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Gellan Gum-Hyaluronate Spongy-like Hydrogels Promote Angiogenesis in Hindlimb Ischemia.
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Cerqueira M. T.
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Santos T. C.
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Hind limb ischemia in type 1 diabetic mice as useful tool to evaluate the neovascularization of tissue engineering constructs
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2016
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Natural melanin promotes the differentiation of an early epidermal cell fraction and the scavenging of ROS.
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Pinto A. R.
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Testing Natural Biomaterials in Animal Models
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2017
Correia C.
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Reis R. L.
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Mano J. F.
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In Vivo Osteogenic Differentiation of Stem Cells Inside Compartmentalized Capsules Loaded with Co-cultured Endothelial Cells
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da Silva L. P.
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Stem Cell-Containing Hyaluronic Acid-Based Spongy Hydrogels for Integrated Diabetic Wound Healing
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da Silva L. P.
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Eumelanin-releasing spongy-like hydrogels for skin re-epithelialization purposes.
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Costa M.
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Ludovico P.
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Cell sheet engineering using the stromal vascular fraction of adipose tissue as a vascularization strategy
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da Silva L. P.
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Santos T. C.
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Stem Cell-Containing Hyaluronic Acid-Based Spongy Hydrogels for Integrated Diabetic Wound Healing
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Santos T. C.
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Can host reaction animal models be used to predict and modulate skin regeneration?
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Rodrigues D. B.
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DENDRIMER-DERIVED ARTIFICIAL ANTIGEN PRESENTATION, METHODS AND USES THEREOF
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2018
Rodrigues D. B.
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Dendrimers: Breaking the paradigm of current musculoskeletal autoimmune therapies
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Vilela C. A.
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Moreira E. S.
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In Vitro and in Vivo Performance of MethacrylatedGellan Gum Hydrogel Formulations for Cartilage Repair
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