Papers in Scientific Journals (27)
Soares da Costa D., Sousa J. C., da Mesquita S., Petkova-Yankova N., Marques F., Reis R. L., Sousa N., and Pashkuleva I.,
"Bioorthogonal Labeling Reveals Different Expression of Glycans in Mouse Hippocampal Neuron Cultures during Their Development",
Molecules, vol. 25, issue 4, pp. 795, doi:
10.3390/molecules25040795, 2020.
Chowdury H. H., Cerqueira S. R., Sousa N., Oliveira J. M., Reis R. L., and Zorec R.,
"The Uptake, Retention and Clearance of Drug-Loaded Dendrimer Nanoparticles in Astrocytes - Electrophysiological Quantification",
Biomaterials Science, vol. 6, issue 2, pp. 388-397, doi:
10.1039/C7BM00886D, 2018.
Cengiz I. F., Pereira H., Pego J. M., Sousa N., Espregueira-Mendes J., Oliveira J. M., and Reis R. L.,
"Segmental and regional quantification of 3D cellular density of human meniscus from osteoarthritic knee",
Journal of Tissue Engineering and Regenerative Medicine, vol. 11, pp. 1844-1852, doi:
10.1002/term.2082, 2017.
Duarte A. R. C., Maniglio D., Sousa N., Mano J. F., Reis R. L., and Migliaresi C.,
"From honeycomb- to microsphere-patterned surfaces of poly(lactic acid) and a starch-poly(lactic acid) blend via the breath figure method",
Journal of Applied Biomaterials & Functional Materials, vol. 15, issue 1, pp. e31-e42, doi:
10.5301/jabfm.5000281, 2017.
Canha-Gouveia A., Costa-Pinto A. R., Martins A., Silva N. A., Faria S., Sousa R. A., Salgado A. J., Sousa N., Reis R. L., and Neves N. M.,
"Hierarchical scaffolds enhance osteogenic differentiation of human Wharton’s Jelly derived Stem Cells",
Biofabrication, vol. 7, issue 3, pp. 035009, doi:
10.1088/1758-5090/7/3/035009, 2015.
Ribeiro-Samy S. M., Silva N. A., Correlo V. M., Fraga J. S., Pinto L. A., Teixeira-Castro A., Leite-Almeida H., Almeida A., Gimble J. M., Sousa N., Salgado A. J., and Reis R. L.,
"Development and Characterization of a PHB-HV-based 3D Scaffold for a Tissue Engineering and Cell-therapy Combinatorial Approach for Spinal Cord Injury Regeneration",
Macromolecular Bioscience, doi:
10.1002/mabi.201300178, 2013.
Fraga J. S., Silva N. A., Lourenço A. S., Gonçalves V., Neves N. M., Reis R. L., Rodrigues A. J., Manadas B., Sousa N., and Salgado A. J.,
"Unveiling the effects of the Secretome of Mesenchymal Progenitors from the Umbilical Cord in Different Neuronal Cell Populations",
Biochemie, vol. 95, issue 12, pp. 2297-2303, doi:
10.1016/j.biochi.2013.06.028, 2013.
Silva N. A., Gimble J. M., Sousa N., Reis R. L., and Salgado A. J.,
"Modulation of Bone Marrow Mesenchymal Stem Cell Secretome by ECM-Like Hydrogels.",
STEM CELLS AND DEVELOPMENT olume 22, Number 8, 2013, vol. 22, issue 8, pp. 1232-1240, doi:
doi: 10.1089/scd.2012.0524, 2013.
Pojo M., Cerqueira S. R., Mota T., Xavier-Magalhães A., Oliveira J. M., Samy S. M., Mano J. F., Reis R. L., Costa B. M., Sousa N., and Salgado A. J.,
"In vitro evaluation of the cytotoxicity and cellular uptake of CMCht/PAMAM dendrimer nanoparticles by glioblastoma cell models",
Journal of Nanoparticle Research (NANO), doi:
10.1007/s11051-013-1621-6, 2013.
Cerqueira S. R., Oliveira J. M., Silva N. A., Leite-Almeida H., Samy S. M., Almeida A., Mano J. F., Sousa N., Salgado A. J., and Reis R. L.,
"Microglia response and in vivo therapeutic potential of methylprednisolone-loaded dendrimer nanoparticles in spinal cord injury",
Small, vol. 9, issue 5, pp. 738-749, 2013.
Silva-Correia J., Miranda-Gonçalves V., Salgado A. J., Sousa N., Oliveira J. M., Reis R. M., and Reis R. L.,
"Angiogenic potential of gellan gum-based hydrogels for application in nucleus pulposus regeneration: In vivo study",
Tissue Engineering Part A, vol. 18, issue 11-12, pp. 1203-1212, doi:
10.1089/ten.TEA.2011.0632, 2012.
Silva N. A., Sousa R. A., Pires A. O., Sousa N., Salgado A. J., and Reis R. L.,
"Interactions Between Schwann and Olfactory Ensheathing Cells with a Starch/Polycaprolactone Scaffold aimed at Spinal Cord Injury Repair",
Journal of Biomedical Materials Research Part A, vol. 100A, issue 2, pp. 470-476, 2011.
Pereira V. H., Salgado A. J., Oliveira J. M., Cerqueira S. R., Frias A. M., Fraga J. S., Roque S., Falcão A. M., Marques F. M., Neves N. M., Mano J. F., Reis R. L., and Sousa N.,
"In Vivo Biodistribution of Carboxymethylchitosan/Poly(amidoamine) Dendrimer Nanoparticles in Rats",
Journal of Bioactive and Compatible Polymers, vol. 26, issue 6, pp. 619–627, 2011.
Pereira D. R., Silva-Correia J., Caridade S. G., Oliveira J. T., Sousa R. A., Salgado A. J., Oliveira J. M., Mano J. F., Sousa N., and Reis R. L.,
"Development of Gellan-Gum based Microparticles/Hydrogel Matrices for Application in the Intervertebral Disc Regeneration",
Tissue Engineering Part C: Methods, vol. 17, issue 10, pp. 961-972, doi:
10.1089/ten.TEC.2011.0115, 2011.
Cerqueira S. R., Silva B. L., Oliveira J. M., Mano J. F., Sousa N., Salgado A. J., and Reis R. L.,
"Multifunctionalized CMCht/PAMAM Dendrimer Nanoparticles Modulate theCellular Uptake by Astrocytes and Oligodendrocytes in Primary Cultures of Glial Cells",
Macromolecular Bioscience, vol. 12, pp. 591–597, doi:
10.1002/mabi.201100294, 2011.
Salgado A. J., Oliveira J. M., Pirraco R. P., Pereira V. H., Fraga J. S., Marques A. P., Neves N. M., Mano J. F., Reis R. L., and Sousa N.,
"Carboxymethyl-chitosan/Poly(amidoamine) Dendrimer Nanoparticles in Central Nervous System Regenerative Medicine: Effects on Neurons/Glial Cells Viability and Internalization efficiency",
Macromolecular Bioscience, vol. 10, issue 10, pp. 1130-1140, 2011.
Salgado A. J., Fraga J. S., Mesquita A. R., Neves N. M., Reis R. L., and Sousa N.,
"Role of human cord mesenchymal progenitors conditioned media in neuronal/glial cell densities, viability, and proliferation",
Stem Cells And Development, doi:
10.1089/scd.2009.0279., 2010.
Silva N. A., Salgado A. J., Sousa R. A., Oliveira J. T., Pedro A. J., Leite-Almeida H., Cerqueira R., Almeida A., Mastronardi F., Mano J. F., Neves N. M., Sousa N., and Reis R. L.,
"Development and characterization of a novel hybrid tissue engineering-based scaffold for spinal cord injury repair",
Tissue Engineering Part A, vol. 16, issue 1, pp. 45-54, 2010.
Pereira V. H., Cerqueira S. R., Fraga J. S., Oliveira J. M., Mano J. F., Salgado A. J., Reis R. L., and Sousa N.,
"Dose dependent effects of FITC-labeled CMC/PAMAM dendrimer nanoparticles on central nervous system derived cells: In vitro and in vivo evaluation",
Tissue Engineering and Regenerative Medicine, vol. 6, issue 12, pp. S119, 2009.
Salgado A. J., Sousa R. A., Fraga J. S., Pego J. M., Silva B. A., Malva J. O., Neves N. M., Reis R. L., and Sousa N.,
"Effects of Starch/ Polycaprolactone-based Blends for Spinal Cord Injury Regeneration in Neurons/Glial Cells Viability and Proliferation",
Journal of Bioactive and Biocompatible Polymers, vol. 24, pp. 235-247, 2009.
Ribeiro C. A., Salgado A. J., Fraga J. S., Neves N. M., Gimble J. M., Reis R. L., and Sousa N.,
"A comparative study on the effects of adipose tissue derived and bone marrow mesenchymal stem cells on neurons/glial cells viability, proliferation and differentiation",
Tissue Engineering Part A, vol. 14, issue 5, pp. 800-801, 2008.
Salgado A. J., Fraga J. S., Neves N. M., Reis R. L., and Sousa N.,
"Human umbilical cord perivascular cells (HUCPVCs) as source of mesenchymal progenitors for central nervous system regenerative medicine: Role of paracrine factors and direct cell-to-cell contacts in neurons/glial cells viability, proliferation and differe",
Tissue Engineering, vol. 13, issue 7, pp. 1707-1707, 2008.
Salgado A. J., Sousa R. A., Oliveira J. T., Silva N. A., Neves N. M., Reis R. L., and Sousa N.,
"Novel tissue engineering 3D scaffolds for spinal cord injury based on starch/polycaprolactone blends: Development and preliminary assessment of their biological performance",
Tissue Engineering, vol. 13, issue 7, pp. 1736-1737, 2008.
Silva N. A., Salgado A. J., Sousa R. A., Oliveira J. T., Neves N. M., Mano J. F., Sousa N., and Reis R. L.,
"Starch/gellan gum hybrid 3D guidance systems for spinal cord injury regeneration: Scaffolds processing, characterization and biological evaluation",
Tissue Engineering Part A, vol. 14, issue 5, pp. 779-779, 2008.
Salgado A. J., Fraga J. S., Neves N. M., Reis R. L., and Sousa N.,
"Role of paracrine factors released by mesenchymal progenitors from the umbilical cord in neurons/glial cell viability, proliferation and differentiation",
Tissue Engineering Part A, vol. 14, issue 5, pp. 695-695, 2008.
Review Paper (3)
Salgado A. J., Oliveira J. M., Matins A., Teixeira F. G., Silva N. A., Neves N. M., Reis R. L., and Sousa N.,
"Tissue Engineering and Regenerative Medicine: Past, Present, and Future",
Int Rev Neurobiol., vol. 108, pp. 11-33, 2013.
Oliveira J. M., Salgado A. J., Sousa N., Mano J. F., and Reis R. L.,
"Dendrimers and Derivatives as a Potential Therapeutic Tool in Regenerative Medicine Strategies - A Review",
Progress in Polymer Science , vol. 35, issue 9, pp. 1163-1194, doi:
10.1016/j.progpolymsci.2010.04.006, 2012.
Mano J. F., Sousa N., Boesel L. F., Neves N. M., and Reis R. L.,
"Bioinert, biodegradable and injectable polymeric matrix composites for hard tissue replacement: state of the art and recent developments",
Composites Science and Technology, vol. 64, pp. 789–817, 2004.
Book Chapter (2)
Salgado A. J., Oliveira J. M., Martins A., Teixeira F. G., Silva N. A., Neves N. M., Sousa N., and Reis R. L.,
"Tissue Engineering and Regenerative Medicine: Past, Present, and Future",
Tissue Engineering of the Peripheral Nerve: Stem Cells and Regeneration Promoting FactorsAcademic Press,
Eds. Geuna S., Perroteau I., Tos P., and Battiston B.,
Academic Press, vol. 108, pp. 1-33, doi:
10.1016/B978-0-12-410499-0.00001-0, 2013.
Salgado A. J., Silva N. A., Neves N. M., Reis R. L., and Sousa N.,
"Hydrogel Based Systems for Spinal Cord Injury Regeneration",
Handbook of Natural-based Polymers for Biomedical Applications,
Reis RL,
Cambridge, pp. in press, 2007.
Invited Lecture (4)
Cerqueira S. R., Oliveira J. M., Salgado A. J., Sousa N., and Reis R. L.,
"Nanoparticle-mediated drug delivery systems for spinal cord injury repair",
Miami Project Lecture Series, The Miami Project To Cure Paralysis, Miller School of Medicine, University of Miami, 2012.
Conference Abstract -ISI Web of Science Indexed (9)
Cerqueira S. R., Chowdhury H. H., Mano J. F., Oliveira J. M., Sousa N., Zorec R., and Reis R. L.,
"Unveiling the intracellular trafficking of drug-loaded dendrimer nanoparticles in astrocytes",
J Tissue Eng Regen Med, vol. 8, issue 1, pp. 39-206, doi:
10.1002/term.1931, 2014.
Cerqueira S. R., Oliveira J. M., Silva B. L., Silva N. A., Mano J. F., Sousa N., Salgado A. J., and Reis R. L.,
"Intracellular delivery of methylprednisolone by dendrimer-based nanoparticles improves the locomotor outcomes after spinal cord injury",
Journal of Tissue Engineering and Regenerative Medicine, vol. 6, issue Suppl.2, pp. 19-19, doi:
10.1002/term.1608, 2012.
Cerqueira S. R., Pereira V. H., Oliveira J. M., Sousa N., Salgado A. J., and Reis R. L.,
"Biodistribution and preliminary therapeutic potential of CMCht/PAMAM dendrimer nanoparticles administration in rats",
Journal of Tissue Engineering and Regenerative Medicine, vol. 6, issue Suppl.1, pp. 88, doi:
10.1002/term.1586, 2012.
Silva B. L., Cerqueira S. R., Fevereiro J. P., Pirraco R. P., Marques A. P., Oliveira J. M., Reis R. L., Sousa N., and Salgado A. J.,
"Hyaluronic acid/poly(amidoamine) dendrimer nanoparticles for central nervous system applications: In vitro and in vivo studies",
Journal of Tissue Engineering and Regenerative Medicine, vol. 6, issue Suppl.1, pp. 361-361, doi:
10.1002/term.1586, 2012.
Teixeira F. G., Carvalho M. M., Silva N. A., Marques F., Mesquita S. D., Neves N. M., Reis R. L., Pinto L., Sousa N., and Salgado A. J.,
"Using the secretome of mesenchymal progenitors of the umbilical cord as a modulator of neural and glial survival, viability and differentiation",
Journal of Tissue Engineering and Regenerative Medicine, vol. 6, issue Suppl. 1, pp. 281-282, doi:
10.1002/term.1586, 2012.
Cerqueira S. R., Oliveira J. M., Mano J. F., Salgado A. J., Sousa N., and Reis R. L.,
"Intracellular Methylprednisolone Release to Glial Cells Using An Engineered Dendrimer Nanoparticle System",
The International Journal of Artificial Organs, vol. 34, issue 8, pp. 639, 2011.
Cerqueira S. R., Oliveira J. M., Mano J. F., Sousa N., Salgado A. J., and Reis R. L.,
"Dendrimer-based nanoparticle delivery system for the sustained and intracellular delivery of methylprednisolone to CNS cells: potential application in spinal cord injury treatment",
Histology and Histopathology, vol. 26, issue supplement1, pp. 323-324, 2011.
Oliveira J. M., Salgado A. J., Pirraco R. P., Pereira V. H., Fraga J. S., Marques A. P., Neves N. M., Mano J. F., Sousa N., and Reis R. L.,
"In Vitro Characterization on the Interactions Between Carboxymethyl-chitosan/Poly(amidoamine) Dendrimer Nanoparticles and Neurons/Glial Cells",
Tissue Engineering: Part A, vol. 14, pp. 744, 2010.
Cerqueira S. R., Oliveira J. M., Mano J. F., Sousa N., Salgado A. J., and Reis R. L.,
"Cell targeted nano-based drug delivery systems for spinal cord injury regeneration",
Tissue Engineering and Regenerative Medicine, vol. 6, issue 12, pp. S82, 2009.