Sweet building blocks for selfassembling biomaterials with molecular recognition

last updated: 2018-10-17
ProjectCytoNanoHeal :: publications list
TitleSweet building blocks for selfassembling biomaterials with molecular recognition
Publication TypeBook Chapter
Year of Publication2018
AuthorsBrito A., Reis R. L., Pires R. A., and Pashkuleva I.
EditorsAzevedo H. S., and da Silva R. M. P.
Abstract Text

After billions of years of evolution not a single live cell has emerged that does not cover itself with a dense code of glycans: carbohydrates are involved in all essential processes within the life cycle of cells and organisms. They exercise their bioactivities via simultaneous multivalent non-covalent interactions with other biomolecules such as proteins. Supramolecular polymers are ideal systems to generate polyvalent architectures for studying and modulating these interactions: the inherent reversibility of the self-assembling process and the translation of monomers into polymers provides control over ligand density and assembly architecture. We present briefly some recent approaches to develop such systems and to use them in different biomedical applications.

Book TitleSelf-Assembling Biomaterials - Molecular Design, Characterization and Application in Biology and Medicine
PublisherWoodhead Publishing
ISBN 9780081020159
Keywordscarbohydrates, glycodendrimers, glycopeptides, glycopolymers, Glycosaminoglycans, GLYCOSYLATION, lectins, supramolecular systems
RightsembargoedAccess (2 Years)
Peer reviewedno

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