Macrophage cell membrane infused biomimetic liposomes for glioblastoma targeted therapy

last updated: 2024-02-02
ProjectHEALTH UNORTE :: publications list
TitleMacrophage cell membrane infused biomimetic liposomes for glioblastoma targeted therapy
Publication TypePapers in Scientific Journals
Year of Publication2023
AuthorsMendanha D., Vieira de Castro J., Casanova M. R., Gimondi S., Ferreira H., and Neves N. M.

Glioblastoma (GBM) is a highly aggressive malignant brain tumor currently without an effective treatment. Inspired by the recent advances in cell membrane biomimetic nanocarriers and by the key role of macrophages in GBM pathology, we developed macrophage membrane liposomes (MML) for GBM targeting. For the first time, it was assessed the role of macrophage polarization states in the effectiveness of these drug delivery systems. Interestingly, we observed that MML derived from M2 macrophages (M2 MML) presents higher uptake and increased delivery of the anticarcinogenic drug doxorubicin compared to M1 macrophage-derived nanocarriers (M1 MML) and control liposomes (CL). Moreover, the lowest uptake by macrophages of MML reveals promising immune escaping properties. Notably, M2 macrophages unveiled a higher expression of integrin CD49d, a crucial protein involved in the bilateral communication of macrophages with tumor cells. Therefore, our findings suggest the potential of using M2 macrophage membranes to develop novel nanocarriers targeting GBM.

JournalNanomedicine: Nanotechnology, Biology and Medicine
Date Published2023-04-03
KeywordsBiomimetic liposomes, Cell membrane, Glioblastoma, macrophages
Peer reviewedyes

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