Hydrogel Nanomaterials for Cancer Diagnosis and Therapy

last updated: 2017-06-02
ProjectComplexiTE :: publications list
TitleHydrogel Nanomaterials for Cancer Diagnosis and Therapy
Publication TypeBook Chapter
Year of Publication2017
AuthorsPires R. A., Abul-Haija Y. M., Reis R. L., Ulijn R. V., and Pashkuleva I.
EditorsSingh T. R. R., Laverty G., and Donnelly R.
Abstract Text

Biocatalytic self-assembly (BSA) has recently emerged as a promising approach for cancer diagnosis and treatment. The concept is based on the transformation of non self-assembling amphiphiles into self-assembling ones due to a physiological stimulus and/or activity of biomolecules. Overexpression of enzymes and changes in pH are the most common triggers used in cancer related BSA resulting in fibrillization at the site of expression. The generattion of nanofibers at a specific location can be used either as a diagonistic tool for early cancer detection as the assembly process changes dramatically the fluorescence intensity and thus, enables powerfull imaging strategies; or as apoptotic inducers for cancer cells. Transformation from micellar structures to nanofibers can also be used in the design of drug release systems. This chapter discusses different strategies, molecular designs and applications of BSA for cancer diagnosis and therapy.

Book TitleHydrogels: Design, Synthesis and Application in Drug Delivery & Regenerative Medicine
Pagination170 - 183
PublisherCRC Press
ISBN 9781498748612
Keywordsbiocatalysis, Cancer, carbohydrate amphiphiles, Drug delivery, enzyme-responsive, Hydrogels, peptide amphiphiles, self-assembly
Peer reviewedno

Back to top