Epitope-imprinted polymers: Design principles of synthetic binding partners for natural biomacromolecules

last updated: 2021-11-04
ProjectSmarTendon :: publications list
TitleEpitope-imprinted polymers: Design principles of synthetic binding partners for natural biomacromolecules
Publication TypeReview Paper
Year of Publication2021
AuthorsTeixeira S. P. B., Reis R. L., Peppas N. A., Gomes M. E., and Domingues R. M. A.
Abstract Text

Molecular imprinting (MI) has been explored as an increasingly viable tool for molecular recognition in various fields. However, imprinting of biologically relevant molecules like proteins is severely hampered by several problems. Inspired by natural antibodies, the use of epitopes as imprinting templates has been explored to circumvent those limitations, offering lower costs and greater versatility. Here, we review the latest innovations in this technology, as well as different applications where MI polymers (MIPs) have been used to target biomolecules of interest. We discuss the several steps in MI, from the choice of epitope and functional monomers to the different production methods and possible applications. We also critically explore how MIP performance can be assessed by various parameters. Last, we present perspectives on future breakthroughs and advances, offering insights into how MI techniques can be expanded to new fields such as tissue engineering.

JournalScience Advances
Pagination eabi9884
Date Published2021-10-29
PublisherAmerican Association for the Advancement of Science
Keywordsbiomacromolecules, epitopes, Molecular imprinting, Molecular recognition, Polymers
Peer reviewedyes

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