Release of Bioactive Agent from Liposomes Immobilized on Electrospun Nanofibers Targeting Tissue Engineering Applications

last updated: 2013-08-04
TitleRelease of Bioactive Agent from Liposomes Immobilized on Electrospun Nanofibers Targeting Tissue Engineering Applications
Publication TypeComunications - Poster
Year of Publication2013
AuthorsMonteiro N., Martins A., Pires R. A., Faria S., Fonseca N. A., Moreira J. N., Reis R. L., and Neves N. M.
Abstract

The ability to manipulate and control the surface properties is of crucial importance in the designing of scaffolds for Tissue Engineering (TE) and Regenerative Medicine. Electrospun nanofibers (NFM), due to their morphology and fibrous structure have received much attention as potential biomedical devices, TE scaffolds and drug delivery carriers. Liposomes, a nanoparticle release system made by physiological material (phospholipids), hold tremendous promise as release systems. Liposomes may be combined with scaffolds to maintain a sustained and local delivery of the loaded drugs. The main objective of the present study is to evaluate the efficacy of dexamethasone (Dex) loaded liposomes immobilized on the surface of polycaprolactone (PCL) electrospun NFM as release system, for the induction of the osteogenic differentiation of mesenchymal stem cells (MSCs). 

Conference Name2013 Annual Meeting of the Society For Biomaterials (SFB)
Date Published2013-04-10
Conference LocationBoston, USA
KeywordsLiposome, nanofibers, Stem cells
RightsopenAccess
Peer reviewedno
Statuspublished

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