Lysozyme incorporation in biomimetic coated chitosan scaffolds: Development and behaviour in contact with osteoblastic-like cells

last updated: 2013-02-25
TitleLysozyme incorporation in biomimetic coated chitosan scaffolds: Development and behaviour in contact with osteoblastic-like cells
Publication TypeConference Abstract -ISI Web of Science Indexed
Year of Publication2006
AuthorsMartins A. M., Salgado A. J., Azevedo H. S., Leonor I. B., and Reis R. L.
Abstract

This work aimed at developing an in-vivo smart and responsive scaffold, presenting properties that will be regulated by the bone regeneration process, leading to the gradual formation of pores in-situ and consequent resorption. The approach consists in the incorporation of lysozyme into a calcium-phosphate (Ca-P) coating generated by a biomimetic route [1] on the surface of biodegradable chitosan scaffolds as way to tailor their degradation rate. Furthermore, since lysozyme has antibacterial properties, these coatings may act as carriers for its sustained release, preventing infection upon implantation.

References: [1] R. L. Reis et al., J. Mater. Sci: Mater. Med. 1997; 8: 897-905.

JournalTissue Engineering
Volume12
Issue4
Pagination1018-1019
Date Published2006-04-24
PublisherMARY ANN LIEBERT INC
ISSN1076-3279
KeywordsBiomimetic coatings, proteins
RightsrestrictedAccess
Peer reviewedyes
Statuspublished

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