Anti-proliferative activity of meroditerpenoids isolated from the brown alga Stypopodium flabelliforme against several cancer cell lines

last updated: 2014-05-19
TitleAnti-proliferative activity of meroditerpenoids isolated from the brown alga Stypopodium flabelliforme against several cancer cell lines
Publication TypePapers in Scientific Journals
Year of Publication2011
AuthorsPereira D. M., Cheel J., Silva L., Valentão P., Areche C., San-Martin A., and Andrade P. B.
Abstract

The sea constitutes one of the most promising sources of novel compounds with potential application in human therapeutics. In particular, algae have proved to be an interesting source of new bioactive compounds. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate,
14-ketostypodiol diacetate and stypodiol) isolated from the brown algaStypopodium flabelliforme were tested for their cell proliferation inhibitory activity in five cell lines. Cell lines tested included human colon adenocarcinoma (Caco-2), human neuroblastoma
(SH-SY5Y), rat basophilic leukemia (RBL-2H3), murine macrophages (RAW.267) and Chinese hamster fibroblasts (V79). Antimicrobial activity of the compounds was also evaluated against Staphylococcus aureus, Salmonella typhimurium, Proteus mirabilis, Bacillus cereus, Enterococcus faecalis and Micrococcus luteus. Overall, the compounds showed good activity against all cell lines, with SH-SY5Y and RAW.267 being the most susceptible. Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active. The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.

JournalMarine Drugs
Volume9
Pagination952-962
Date Published2011-10-19
Keywordsanti-proliferative, antimicrobial, meroditerpenoids, Stypopodium flabelliforme
RightsopenAccess
Peer reviewedyes
Statuspublished

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