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2004
Gomes M. E.
,
Bossano C. M.
,
Johnston C. M.
,
Reis R. L.
, and
Mikos A. G.
,
"
Bone Growth Factors Expressed by Marrow Stromal Cells Cultured on Starch/Poly(ƒÕ-caprolactone) Fiber Mesh Scaffolds under Flow Perfusion Conditions
",
Joint Meeting of the Tissue Engineering Society International (TESI) and the European Tissue Engineering Society (ETES)
, 2004.
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Gomes M. E.
,
Mikos A. G.
, and
Reis R. L.
,
"
A bone tissue engineering approach based degradable starch based 3-D scaffolds seeded with bone marrow stromal cells and cultured in a bioreactor
",
POLYCHAR-12 World Forum on Advanced Materials
, 2004.
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Gomes M. E.
,
Bossano C. M.
,
Johnston C. M.
,
Reis R. L.
, and
Mikos A. G.
,
"
Expression of Bone Growth Factors by MSCs Cultured on Starch/poly(ƒÕ-caprolactone) Scaffolds Using a Flow Perfusion Bioreactor
",
7th World Biomaterials Conference
, 2004.
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Gomes M. E.
,
Holtorf H. L.
,
Reis R. L.
, and
Mikos A. G.
,
"
Influence of the Porosity of Starch-Based Fiber Meshes on the Proliferation and Osteogenic Differentiation of Marrow Stromal Cells Cultured under Flow Perfusion
",
7th World Biomaterials Conference
, 2004.
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Oliveira A. L.
,
Santos M. I.
,
Coutinho O. P.
, and
Reis R. L.
,
"
Biomimetic Coatings Incorporating Bisphosphonates Aiming to Inhibit Bone Resorption
",
7th World Biomaterial Congress
, 2004.
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Oliveira A. L.
,
Alves C. M.
, and
Reis R. L.
,
"
Biomimetic Routes for Inducing In Vitro Biomineralization on Starch-Based Polymeric Structures for Bone-Related Applications
",
XVIIth Aachen Colloquium on Biomaterials
, 2004.
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Oliveira A. L.
, and
Reis R. L.
,
"
Biomimetic Strategies for the Pre-Mineralization of Porous Biodegradable Polymeric Scaffolds with a Bone-Like Apatite Layer
",
12th Annual POLYCHAR World Forum on Advanced Materials
, 2004.
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Oliveira A. L.
,
Santos M. I.
,
Pedro A. J.
, and
Reis R. L.
,
"
Bisphosphonates Incorporated on a Ca-P Biomimetic Coating Produced by a Sodium Silicate Based Methodology Stimulate Osteoblastic Activity
",
Bioceramics 17
, 2004.
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Salgado A. J.
,
Coutinho O. P.
, and
Reis R. L.
,
"
Bone Tissue Engineering: State of the Art and Future Trends
",
Macromolecular Biosciences
, vol. 4, pp. 743-765, 2004.
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Pavlov M. P.
,
Mano J. F.
,
Neves N. M.
, and
Reis R. L.
,
"
Production and characterization of fibers and 3D mesh scaffolds from biodegradable starch-based blends
",
Macromolecular Bioscience
, vol. 4, pp. 776, 2004.
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Boesel L. F.
,
Fernandes M. H.
, and
Reis R. L.
,
"
The behaviour of novel hydrophilic, composite bone cements in simulated body fluids
",
Journal of Biomedical Materials Research: Part B: Applied Biomaterials
, vol. 70B, pp. 368-377, 2004.
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Boesel L. F.
, and
Reis R. L.
,
"
Development and characterization of hydrophilic and partially degradable bone cements: an alternative to the conventional acrylic cements
",
17th Aachen Colloquim on Biomaterials
, 2004.
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Boesel L. F.
, and
Reis R. L.
,
"
Hydrophilic matrices to be used as bioactive and degradable bone cements
",
Journal of Materials Science: Materials in Medicine
, vol. 15, pp. 503-506, 2004.
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Boesel L. F.
,
Mano J. F.
,
Fernandes M. H.
,
Cachinho S. C.
, and
Reis R. L.
,
"
The influence of bone-like apatite layers on the creep and dynamic mechanical behaviour of hydrophiic bone cements
",
12th POLYCHAR World Forum on Polymer Applications and Theory
, 2004.
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Boesel L. F.
, and
Reis R. L.
,
"
Injectable biodegradable systems
",
Biodegradable Systems in Tissue Engineering and Regenerative Medicine
,
CRC Press
,
Boca Raton
, pp. 13-28, 2004.
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Boesel L. F.
,
Azevedo H. S.
, and
Reis R. L.
,
"
Novel hydrophilic, partially degradable and bioactive bone cements containing starch and a bioactive glass
",
7th World Biomaterials Congress
, 2004.
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Boesel L. F.
,
Mano J. F.
, and
Reis R. L.
,
"
Optimization of the formulation and mechanical properties of starch based partially degradable bone cements.
",
Journal of Materials Science: Materials in Medicine
, vol. 15, pp. 73-83, 2004.
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Gomes M. E.
,
Malafaya P. B.
, and
Reis R. L.
,
"
Fiber Bonding and Particle Aggregation as Promissing Methodologies For The Fabrication Of Biodegradable Scaffolds For Hard-Tissue Engineering
",
Biodegradable Systems for Tissue in Engineering and Regenerative Medicine
,
CRC Press
,
Boca Raton
, pp. 53-65, 2004.
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Baran E. T.
,
Tuzlakoglu K.
,
Salgado A. J.
, and
Reis R. L.
,
"
Multichannel mould processing of 3D structures from porous coralline hydroxyapatite granules and chitosan support material for tissue regeneration/engineering
",
Journal of Materials Science:Materials in Medicine
, vol. 15, pp. 161-165, 2004.
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Baran E. T.
,
Mano J. F.
, and
Reis R. L.
,
"
Starch-chitosan hydrogels prepared by reductive alkylation crosslinking
",
Journal of Materials Science:Materials in Medicine,
, vol. 15, pp. 759-765, 2004.
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Reis R. L.
,
"
Chitosan/starch scaffolds with in situ pore forming capability for tissue engineering applications
",
Meeting of the Tissue Engineering Society International and the European Tissue Engineering Society (TESI-ETES)
, 2004.
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Martins A. M.
,
Santos M. I.
,
Azevedo H. S.
,
Malafaya P. B.
,
Coutinho O. P.
, and
Reis R. L.
,
"
Chitosan/starch scaffolds with in situ pore forming capability for tissue engineering applications
",
Meeting of the Tissue Engineering Society International and the European Tissue Engineering Society
, 2004.
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Malafaya P. B.
, and
Reis R. L.
,
"
Development and characterization of pH responsive chitosan and chitosan/HA scaffolds processed by a microsphere-based aggregation route
",
7th World Biomaterials Congress
, 2004.
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Alves C. M.
,
Yang Y.
,
Carnes D. L.
,
Ong J. L.
,
Sylvia V. L.
,
Dean D. D.
,
Agrawal C. M.
, and
Reis R. L.
,
"
Plasma Treatment and Adsorption of Single and Complex Plasma Proteins onto Starch-based Materials Affects Adhesion and Proliferation of MG63 Human Osteoblast-like Osteosarcoma Cells
",
7th World Biomaterials Congress
, 2004.
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Silva S. S.
,
Carlos L. D.
,
Rocha J.
,
Mano J. F.
, and
Reis R. L.
,
"
EVALUATION OF THE PROPERTIES OF NOVEL CHITOSAN/SILICA HYBRIDS
",
12thAnnual Polychar World Forum on Advanced Materials
, 2004.
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Salgado A. J.
,
Coutinho O. P.
,
Hutmacher D. W.
,
Davies J. E.
, and
Reis R. L.
,
"
Extruded Starch Based Scaffolds for Bone Tissue Engineering
",
XVIIth Aachen Colloquium on Biomaterials
, 2004.
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Salgado A. J.
,
Coutinho O. P.
,
Reis R. L.
, and
Davies J. E.
,
"
In Vivo Evaluation of Extruded Starch Based Scaffolds for Bone Tissue Engineering Applications
",
7th World Biomaterials Congress
, 2004.
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Silva S. S.
,
Santos M. I.
,
Coutinho O. P.
,
Goodfellow B. J.
,
Rocha J.
,
Mano J. F.
, and
Reis R. L.
,
"
Nano-Scale Interactions, Miscibility and Physical Properties of Novel Biomedical Membranes Composed by Chitosan/Soy Protein Blends
",
7th World Biomaterials Congress
, 2004.
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Salgado A. J.
,
Coutinho O. P.
, and
Reis R. L.
,
"
Novel Starch Based Scaffolds for Bone Tissue Engineering: Cytotoxicity, Cell Culture and Protein Expression
",
Tissue Engineering
, vol. 10, issue 3-4, pp. 665-674, 2004.
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Silva S. S.
,
Oliveira J. M.
,
Mano J. F.
, and
Reis R. L.
,
"
Preparation of Novel Chitosan/Soy Protein Porous Structures for Tissue Engineering Applications
",
Biomaterials In Regeneraive Medicine: The Advent of Combination Products
, 2004.
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Boesel L. F.
,
Fernandes M. H.
, and
Reis R. L.
,
"
The behavior of novel hydrophilic composite bone cements in simulated body fluids
",
Journal of Biomedical Materials Research Part B-Applied Biomaterials
, vol. 70B, issue 2, pp. 368-377, 2004.
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Vaz C. M.
,
vanDoeveren P.
,
Dias G. R.
,
Reis R. L.
, and
Cunha A. M.
,
"
Controlled delivery achieved with bi-layer matrix devices produced by co-injection moulding
",
Macromolecular Bioscience
, vol. 4, issue 8, pp. 795-801, 2004.
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Marques A. P.
,
Reis R. L.
, and
Hunt J. A.
,
"
Cytokine secretion from mononuclear cells cultured in vitro with starch-based polymers and poly-L-lactide
",
Journal of Biomedical Materials Research Part A
, vol. 71A, issue 3, pp. 419-429, 2004.
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Souto R. M.
,
Lemus M. M.
, and
Reis R. L.
,
"
Electrochemical behavior of different preparations of plasma-sprayed hydroxyapatite coatings on Ti6Al4V substrate
",
Journal of Biomedical Materials Research Part A
, vol. 70A, issue 1, pp. 59-65, 2004.
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Costa S. A.
, and
Reis R. L.
,
"
Immobilisation of catalase on the surface of biodegradable starch-based polymers as a way to change its surface characteristics
",
Journal of Materials Science-Materials in Medicine
, vol. 15, issue 4, pp. 335-342, 2004.
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Silva R. M.
,
Elvira C.
,
Mano J. F.
,
SanRoman J.
, and
Reis R. L.
,
"
Influence of beta-radiation sterilisation in properties of new chitosan/soybean protein isolate membranes for guided bone regeneration
",
Journal of Materials Science-Materials in Medicine
, vol. 15, issue 4, pp. 523-528, 2004.
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Sousa R. A.
,
Reis R. L.
,
Cunha A. M.
, and
Bevis M. J.
,
"
Integrated compounding and injection moulding of short fibre reinforced composites
",
Plastics Rubber and Composites
, vol. 33, issue 6, pp. 249-259, 2004.
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Baran E. T.
,
Tuzlakoglu K.
,
Salgado A. J.
, and
Reis R. L.
,
"
Multichannel mould processing of 3D structures from microporous coralline hydroxyapatite granules and chitosan support materials for guided tissue regeneration/engineering
",
Journal of Materials Science-Materials in Medicine
, vol. 15, issue 2, pp. 161-165, 2004.
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Salgado A. J.
,
Coutinho O. P.
, and
Reis R. L.
,
"
Novel starch-based scaffolds for bone tissue engineering: Cytotoxicity, cell culture, and protein expression
",
Tissue Engineering
, vol. 10, issue 3-4, pp. 465-474, 2004.
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Vaz C. M.
,
deGraaf L. A.
,
Reis R. L.
, and
Cunha A. M.
,
"
pH-sensitive soy protein films for the controlled release of an anti-inflammatory drug
",
Materials Research Innovations
, vol. 8, issue 3, pp. 149-150, 2004.
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Oliveira A. L.
, and
Reis R. L.
,
"
Pre-mineralisation of starch/polycrapolactone bone tissue engineering scaffolds by a calcium-silicate-based process
",
Journal of Materials Science-Materials in Medicine
, vol. 15, issue 4, pp. 533-540, 2004.
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Silva R. M.
,
Silva G. A.
,
Coutinho O. P.
,
Mano J. F.
, and
Reis R. L.
,
"
Preparation and characterisation in simulated body conditions of glutaraldehyde crosslinked chitosan membranes
",
Journal of Materials Science-Materials in Medicine
, vol. 15, issue 10, pp. 1105-1112, 2004.
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Silva G. A.
,
Costa F. J.
,
Coutinho O. P.
,
Radin S.
,
Ducheyne P.
, and
Reis R. L.
,
"
Synthesis and evaluation of novel bioactive composite starch/bioactive glass microparticles
",
Journal of Biomedical Materials Research Part A
, vol. 70A, issue 3, pp. 442-449, 2004.
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Mano J. F.
, and
Reis R. L.
,
"
Viscoelastic monitoring of starch-based biomaterials in simulated physiological conditions
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Materials Science and Engineering a-Structural Materials Properties Microstructure and Processing
, vol. 370, issue 1-2, pp. 321-325, 2004.
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Marques A. P.
,
Reis R. L.
, and
Hunt J. A.
,
"
In Vitro and In Vivo Inflammatory Reaction to Starch-Based Biomaterials. Cellular and Chemical Mediators
",
7th World Biomaterials Congress
, 2004.
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Marques A. P.
,
Reis R. L.
, and
Hunt J. A.
,
"
Parallelism in the in vitro and in vivo evaluation of the host response to starch-based biomaterials for regenerative medicine
",
Regenerative Medicine: The Advent of Combination Products
, 2004.
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Costa D.
,
Marques A. P.
,
Reis R. L.
,
Reis S.
,
Lima J. L.
, and
Fernandes E.
,
"
Screening of antioxidant activity of dipyrone and related derivatives using cellular and non cellular in vitro assays
",
2nd Spanish and Portuguese Congress on Free Radicals
, 2004.
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Pashkuleva I.
,
Marques A. P.
,
Vaz F.
, and
Reis R. L.
,
"
Starch-based biomaterials: effect of modifying the surface properties on cell adhesion/proliferation
",
12th Annual Polychar World Forum on Advanced Materials
, 2004.
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Salgado A. J.
,
Coutinho O. P.
, and
Reis R. L.
,
"
Bone tissue engineering: State of the art and future trends
",
Macromolecular Bioscience
, vol. 4, issue 8, pp. 743-765, 2004.
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2005
Neves N. M.
,
Mano J. F.
, and
Reis R. L.
,
"
Biodegradable Composites for Biomedical Applications
",
Biodegradable Systems in Tissue Engineering and Regenerative Medicine
,
Eds.
Reis R. L.
, and
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,
CRC Press
, doi:
10.1201/9780203491232.ch7
, 2005.
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Mano J. F.
,
Neves N. M.
, and
Reis R. L.
,
"
Mechanical characterization of biomaterials
",
Biodegradable Systems in Tissue Engineering and Regenerative Medicine
,
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Reis R. L.
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CRC Press
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Silva G. A.
,
Costa F. J.
,
Neves N. M.
,
Coutinho O. P.
, and
Reis R. L.
,
"
Entrapment ability and release profile of corticosteroids from starch-based microparticles
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J Biomed Mater Res A
, vol. 73A, pp. 234-243, 2005.
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Silva G. A.
,
Pedro A. J.
,
Costa F. J.
,
Neves N. M.
,
Coutinho O. P.
, and
Reis R. L.
,
"
Soluble starch and composite starch Bioactive Glass 45S5 particles: Synthesis, bioactivity, and interaction with rat bone marrow cells
",
Materials Science and Engineering C 25 (2005) 237 – 246
, vol. 25, pp. 237 – 246, 2005.
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Azevedo H. S.
,
Leonor I. B.
,
Alves C. M.
, and
Reis R. L.
,
"
Incorporation of proteins and enzymes at different stages of the preparation of calcium phosphate coatings on a degradable substrate by a biomimetic methodology
",
Materials Science & Engineering C-Biomimetic and Supramolecular Systems
, vol. 25, issue 2, pp. 169-179, doi:
10.1016/j.msec.2005.01.007
, 2005.
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Pedro A. J.
,
Gomes M. E.
, and
Reis R. L.
,
"
Bone Matrix Deposition By Rat Bone Marrow Stem Cells On Scaffolds Designed To Be Enzymaticaly Degraded During Cell Culture
",
4<sup>th</sup> Annual Meeting Of The European Tissue Engineering Society – ETES’05
, 2005.
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Pinho E. D.
,
Boesel L. F.
, and
Reis R. L.
,
"
Optimization Of The Curing Properties Of Hydrophilic Partially Degradable Bioactive Cements Using Statistical Tools
",
30th Annual Meeting of Society For Biomaterials
, 2005.
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Leonor I. B.
,
Azevedo H. S.
,
Alves C. M.
, and
Reis R. L.
,
"
Biomimetic Coatings, Proteins and Biocatalysts: a New Approach to Tailor the Properties of Biodegradable Polymer
",
Biodegradable Systems in Tissue Engineering and Regenerative Medicine
,
CRC Press
,
Boca Raton
, pp. 223-250, 2005.
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Oliveira J. M.
,
Costa S. A.
,
Leonor I. B.
,
Mano J. F.
, and
Reis R. L.
,
"
Carboxymethylchitosan/Calcium phosphate Hybrid Materials Prepared by an Innovative Auto-Catalytic co-Precipitation Method
",
19th European Conference on Biomaterials (ESB2005)
, 2005.
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Leonor I. B.
,
Sousa R. A.
, and
Reis R. L.
,
"
Development of Bioactive Composites based on Biodegradable Systems for Bone Replacement Applications composites
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Biodegradable Systems in Tissue Engineering and Regenerative Medicine
,
CRC Press
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Boca Raton
, pp. 115-126, 2005.
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Oliveira J. M.
,
Silva S. S.
,
Mano J. F.
, and
Reis R. L.
,
"
Innovative Technique for the Preparation of Porous Bilayered Hydroxyapatite/Chitosan Scaffolds for Osteochondral Applications
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Bioceramics 18
, 2005.
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Santos M. I.
,
Gomes M. E.
,
Fuchs S.
,
Unger R. E.
,
Coutinho O. P.
,
Reis R. L.
, and
Kirkpatrick C. J.
,
"
Assessment of Endothelial Cells Response to Starch-based Fiber-Meshes for Bone Tissue Regeneration
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30th Annual Meeting & Exposition -Society for Biomaterials(SFB)
, 2005.
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Azevedo H. S.
,
Leonor I. B.
,
Pereira R. C.
, and
Reis R. L.
,
"
Biomimetic Calcium-Phosphate Coatings as Carriers of Bioactive Proteins: Incorporation, Dissolution and Release Studies
",
30th Annual Meeting of the Society for Biomaterials
, 2005.
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Santos M. I.
,
Martins A. M.
,
Fuchs S.
,
Unger R. E.
,
Reis R. L.
, and
Kirkpatrick C. J.
,
"
Endothelialization of Chitosan/Starch Scaffolds with in situ Forming Ability as a New Approach for Bone Tissue Engineering Applications
",
19th European Conference of Biomaterials, (ESB)
, 2005.
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Costa S. A.
,
Azevedo H. S.
, and
Reis R. L.
,
"
Enzyme Immobilization in Biodegradable Polymers for Biomedical Applications
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CRC Press
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, pp. 301-323, 2005.
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Santos M. I.
,
Tuzlakoglu K.
,
Gomes M. E.
,
Fuchs S.
,
Unger R. E.
,
Reis R. L.
, and
Kirkpatrick C. J.
,
"
Nano- and Micro-fiber Combined Scaffolds: An Innovative Design for Improving Endothelial Cell Migration in Bone Tissue Engineering Approaches
",
8th Annual Meeting of Tissue Engineering Society International, (TESI)
, 2005.
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Azevedo H. S.
,
Leonor I. B.
, and
Reis R. L.
,
"
Proteins Incorporated into Biomimetic Calcium-Phosphate Coatings Are Able to Modulate the Ca-P Layers Properties
",
6th International Symposium on Frontiers in Biomedical Polymers
, 2005.
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Azevedo H. S.
, and
Reis R. L.
,
"
Understanding the Enzymatic Degradation of Biodegradable Polymers and Strategies to Control their Degradation Rate
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Biodegradable Systems in Tissue Engineering and Regenerative Medicine
,
CRC Press
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, pp. 177-201, 2005.
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Alves C. M.
,
Reis R. L.
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Study of the Influence of Beta-Radiation Sterilization on the Properties and Mineralization of Different Starch Based Polymers
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Azevedo H. S.
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Incorporation of Proteins with Different Isoelectric Points into Biomimetic Ca-P Coatings: a New Approach to Produce Hybrid Coatings with Tailored Properties
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Novel Melt Processable Chitosan/Polyester Blends and Composites: Extensive Characterization Aiming at There Biomedical Application
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Preliminary Assessment of the Potential of Chitosan/Polyester Based Scaffolds for Bone and Cartilage Tissue Engineering
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