Project | SPARTAN :: publications list |
Title | Yicathins B and C and analogues: total synthesis, lipophilicity and biological activities |
Publication Type | Papers in Scientific Journals |
Year of Publication | 2020 |
Authors | Loureiro D. R. P., Magalhães A. F., Soares J. X., Pinto J., Azevedo C. M. G., Vieira S. F., Henriques A., Ferreira H., Neves N. M., Bousbaa H., Reis S., Afonso C. M. M., and Pinto M. M. M. |
Abstract | Natural products had always be an important source of new hits and leads in drug discovery. The marine environment has been regarded as a significant souce of novel and exquisite bioactive compounds. Yicathins B and C are two marine derived xanthones that have shown antibacterial and antifungal activities. Herein, the total synthesis of these yicathins is reported for the first time as well as six novel analogues. As marine natural products tend to bear very lipophilic scaffolds, the lipophilicity of yicathins and its analogues was |
Journal | ChemMedChem |
Date Published | 2020-03-11 |
Publisher | WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
ISSN | 1860-7187 |
DOI | 10.1002/cmdc.201900735 |
URL | https://onlinelibrary.wiley.com/doi/10.1002/cmdc.201900735 |
Keywords | Anti-inflammatory, lipophilicity, marine, total synthesis, Xanthone |
Rights | embargoedAccess (2 Years) |
Peer reviewed | yes |
Status | published |