In vitro and in vivo assessment of magnetically actuated biomaterials for tendon regeneration

last updated: 2018-01-29
ProjectRECOGNIZE :: publications list
TitleIn vitro and in vivo assessment of magnetically actuated biomaterials for tendon regeneration
Publication TypeConference Abstract -ISI Web of Science Indexed
Year of Publication2016
AuthorsSantos L. J., Silva M., Gonçalves A. I., Pesqueira T., Rodrigues M. T., Reis R. L., and Gomes M. E.
Abstract

Tendon regeneration can be undermined by the formation of fibrous adhesions (scar tissue) between the healing tendon and the surrounding tissues. Scarring is associated with the recruitment of inflammatory cells such as macrophages and mast cells[1]. To tackle this issue we advocate the implementation of postoperative rehabilitation programmes to control inflammation levels and scarring, ensuring this way better clinical outcomes. In this study we propose the insertion of a magnetic responsive biomaterial between the healing tendon and the surrounding tissues. We hypothesise this material in combination with a magnetic field will modulate inflammation and reduce fibrous adhesion. Here we present the results from the first stage of our study, where magnetic biomaterials were tested subcutaneously to evaluate the inflammatory response and the ability of this material to control the presence of fibrous tissue.

JournalFront. Bioeng. Biotechnol.
Conference Name10th World Biomaterials Congress
Date Published2016-03-30
Conference LocationMontréal, Canada
ISSN2296-4185
DOI10.3389/conf.FBIOE.2016.01.01620
URLhttps://www.frontiersin.org/10.3389/conf.FBIOE.2016.01.01620/event_abstract
Keywordsmedical application, regenerative medicine, stimuli-response
RightsopenAccess
Peer reviewedyes
Statuspublished

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