Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure
last updated: 2021-06-28
| Project | PATH - Programa de Doutoramento Norte 2020 :: publications list |
| Title | Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure |
| Publication Type | Papers in Scientific Journals |
| Year of Publication | 2020 |
| Authors | Araújo A. R., Gigante S. C., Taboada P., Reis R. L., and Pires R. A. |
| Abstract | The isomers vescalagin and castalagin protect SH-SY5Y cells from Aβ42-mediated death. This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 position of the glycosidic chain, improving its capacity to remodel the secondary structure of toxic Aβ42 oligomers.
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| Journal | Chemical Communications |
| Volume | 56 |
| Issue | 21 |
| Pagination | 3187-3190 |
| Date Published | 2020-02-10 |
| Publisher | The Royal Society of Chemistry |
| ISSN | 1359-7345 |
| DOI | 10.1039/D1CC90090K |
| URL | https://pubs.rsc.org/en/content/articlehtml/2020/cc/d0cc00192a |
| Keywords | Alzheimer's disease, amyloid-beta, natural polyphenols |
| Rights | openAccess |
| Peer reviewed | yes |
| Status | published |
