Trapping metastatic cancer cells with mechanical ratchet arrays

last updated: 2023-10-05
ProjectPREMiuM :: publications list
TitleTrapping metastatic cancer cells with mechanical ratchet arrays
Publication TypePapers in Scientific Journals
Year of Publication2023
AuthorsCaballero D., Reis R. L., and Kundu S. C.
EditorsWagner W. R.

Current treatments for cancer, such as chemotherapy, radiotherapy, immunotherapy, and surgery, have positive results but are generally ineffective against metastatic tumors. Treatment effectiveness can be improved by employing bioengineered cancer traps, typically utilizing chemoattractant-loaded materials, to attract infiltrating cancer cells preventing their uncontrolled spread and potentially enabling eradication. However, the encapsulated chemical compounds can have adverse effects on other cells causing unwanted responses, and the generated gradients can evolve unpredictably. Here, we report the development of a cancer trap based on mechanical ratchet structures to capture metastatic cells. The traps use an array of asymmetric local features to mechanically attract cancer cells and direct their migration for prolonged periods. The trapping efficiency was found to be greater than isotropic or inverse anisotropic ratchet structures on either disseminating cancer cells and tumor spheroids. Importantly, the traps exhibited a reduced effectiveness when targeting non-metastatic and non-tumorigenic cells, underscoring their particular suitability for capturing highly invasive cancer cells. Overall, this original approach may have therapeutic implications for fighting cancer, and may also be used to control cell motility for other biological processes.

JournalActa Biomaterialia
Date Published2023-10-05
KeywordsCancer, Directed migration, microfabrication, ratchet, Traps
Peer reviewedyes

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