Project | ECM_INK :: publications list |
Title | TGF-b-laden polysaccharide material to modulate fibroblast-to-myofibroblast transition for scarring control |
Publication Type | Conference Abstract -ISI Web of Science Indexed |
Year of Publication | 2019 |
Authors | Mandon C. A., da Silva L. P., Reis R. L., and Marques A. P. |
Abstract | INTRODUCTION: During the reconstitution, and restoration of the integrity of injured skin, scar formation is frequently observed. A way to study and understand mechanisms underlying scaring and in turn, prevent it, is to focus on the fibroblast-to-myofibroblast transition. This work proposes the development of an ECM like material, linked with TGF-β1 and TGF-β3 growth factors, to generate a 3D platform in which their role and overlapping functions in the fibroblast-to-myofibroblast transition, and consequently on healing and scaring, can be unraveled. |
Journal | European Cells and Materials |
Volume | 3 |
Pagination | 386 |
Date Published | 2019-05-31 |
Publisher | AO Foundation |
ISSN | 2522-235X |
URL | https://www.ecmconferences.org/abstracts/2019/Collection3/collection3.pdf |
Keywords | scarring, Wound healing |
Rights | openAccess |
Peer reviewed | no |
Status | published |