Terpene-Based Natural Deep Eutectic Systems as Efficient Solvents To Recover Astaxanthin from Brown Crab Shell Residues

last updated: 2020-08-28
ProjectDez.Zyme :: publications list
TitleTerpene-Based Natural Deep Eutectic Systems as Efficient Solvents To Recover Astaxanthin from Brown Crab Shell Residues
Publication TypePapers in Scientific Journals
Year of Publication2020
AuthorsRodrigues L., Pereira C. V., Leonardo I., Férnandez N., Gaspar F., Silva J. M., Reis R. L., Duarte A. R. C., Paiva A., and Matias A. A.

The potential of natural deep eutectic systems
(NADESs) to e
fficiently extract astaxanthin (AXT) contained in
crab shell wastes was evaluated. Di
fferent terpene-based mixtures
were prepared and characterized. Aiming at maximizing the AXT
recovery, we evaluated the e
ffect of operating temperature and time
on the extraction performance. As a proof of concept, this paper
also highlights the potential of NADESs for AXT extraction from
shrimp shells, mussels, and
Haematococcus pluvialis. The biological
potential of AXT-rich extracts; the AXT standard; and NADESs,
their individual components, and equivalent physical mixtures was
evaluated, including cytotoxicity, antiproliferative e
ffects on human colorectal cancer cells, and antimicrobial potential against Staphylococcus aureus and Escherichia coli. Results showed that extractions with menthol:myristic acid (8:1) were able to match the AXT yield obtained by a Soxhlet extraction with acetone. Additionally, when using the same NADESs to recover AXT from the other biomasses under study, there was a 3- to 657-fold increase in yields when compared with the Soxhlet extraction. AXT-rich extracts obtained with NADESs showed antiproliferative and antimicrobial potential. This study suggests that NADESs can truly be used as alternative extraction media for the recovery of AXT from waste biomass and that these systems and respective extracts have the potential to be used as ingredients in industrial applications.

JournalACS Sustainable Chemistry Engineering
Date Published2020-01-27
Keywordsantiproliferative and antimicrobial effects, astaxanthin, bioactive extracts, biorefinery, Natural deep eutectic solvents, shell residues
Peer reviewedno

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