Synthesis of mussel-inspired poly(dopamine)-gallium nanoparticles for biomedical applications

last updated: 2021-01-21
Project IF/01285/2015 :: publications list
TitleSynthesis of mussel-inspired poly(dopamine)-gallium nanoparticles for biomedical applications
Publication TypePapers in Scientific Journals
Year of Publication2021
AuthorsTeixeira J. V. U., Maia F. R., Carvalho M. R., Reis R. L., Oliveira J. M., Lisboa-Filho P. N., and Claro A. P. R. A.

Aim: In this work, we established a simple, controlled, and reproducible method to synthesize gallium-coated polydopamine (PDA) nanoparticles. Methods: Polydopamine was synthetized in the alkali medium with posterior gallium shell formation due to ion chelation on the nanoparticle surface. Results: The obtained results with EDS spectra confirmed the incorporation of gallium on PDA surface. The cytotoxicity of Ga-coated PDA nanoparticles was evaluated in vitro at different concentrations in contact with human adipose-derived stem cells (hASCs). Further cell analysis also demonstrated the benefit of Ga-coated PDA, which increased the cell proliferation rate compared to non-coated PDA. Conclusion: This study indicated that gallium could work as an appropriate shell for PDA particles, inducing cell proliferation at the analyzed concentrations.

Date Published2021-01-07
PublisherFuture Medicine
Keywordscore/shell, cytotoxicity, gallium incorporation, nanoparticle synthesis
Peer reviewedyes

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