Stromal Vascular Fraction Obtained From Subcutaneous Adipose Tissue: Ex-Obese and Older Population as Main Clinical Targets
| Title | Stromal Vascular Fraction Obtained From Subcutaneous Adipose Tissue: Ex-Obese and Older Population as Main Clinical Targets |
| Publication Type | Papers in Scientific Journals |
| Year of Publication | 2022 |
| Authors | Frias F., Matos B., Jarnalo M., Freitas-Ribeiro S., Reis R. L., Pirraco R. P., and Horta R. |
| Abstract | IntroductionHuman adipose tissue contains a heterogeneous and synergistic mixture of cells called stromal vascular fraction (SVF) with highly proliferative and angiogenic properties, conferring promising applicability in the field of regenerative medicine. This study aims to investigate if age, body mass index (BMI), history of obesity and massive weight loss, and harvest site are related to SVF cell marker expression. MethodsA total of 26 samples of subcutaneous adipose tissue were harvested from patients admitted to the Plastic and Reconstructive department in University Hospital Center of São João, Porto, Portugal, for body contouring surgery. The percentage of cells expressing CD31, CD34, CD45, CD73, CD90, and CD105 was assessed and compared with patient's age, BMI, history of obesity and massive weight loss (ex-obese group), and harvest site. ResultsIn the ex-obese group, a significantly higher number of cells expressing CD90 (P = 0.002) was found. BMI, harvest site, and age appear to have no association with SVF subpopulations. |
| Journal | Journal Of Surgical Research |
| Volume | 283 |
| Pagination | 632-639 |
| Date Published | 2022-11-26 |
| Publisher | Elsevier |
| ISSN | 1095-8673 |
| DOI | 10.1016/j.jss.2022.11.012 |
| URL | https://www.sciencedirect.com/science/article/pii/S002248042200751X |
| Keywords | adipose-derived stem cells, CD90, regenerative medicine, stromal vascular fraction |
| Rights | openAccess |
| Peer reviewed | yes |
| Status | published |
