Title | Silk fibroin/chitosan pH-sensitive controlled microneedles |
Publication Type | Papers in Scientific Journals |
Year of Publication | 2023 |
Authors | Jia T., Kuang D., Qi Z., Tan G., Yang X., Kundu S. C., and Lu S. |
Abstract | Silk fibroin is a widely used biocompatible medical material with tunable mechanical, degradability and environmental non-toxicity. This paper prepared the silk fibroin/chitosan hydrogel microneedle with pH sensitivity by blending silk fibroin with chitosan to induce graft cross-linking. The cross-linked silk fibroin/chitosan microneedles network is expanded by hydrogen ions and water molecules, forming a more significant swelling. In vitro, the transdermal drug release showed that insulin loaded in microneedles exhibited pH-sensitive drug release behavior and was released faster under acidic conditions than under neutral conditions. By changing the pH of the solution, microneedles can achieve a stimulating response to the environment, thereby intelligently regulating the transdermal release of insulin. |
Journal | Journal of Materials Science |
Volume | 58 |
Issue | 46 |
Pagination | 17711–17725 |
Date Published | 2023-12-03 |
Publisher | Springer |
ISSN | 0022-2461 |
DOI | 10.1007/s10853-023-09148-1 |
URL | https://link.springer.com/article/10.1007/s10853-023-09148-1#article-info |
Keywords | Chitosan, Fibroin microneedles, Glucose-responsive insulin, hydrogel |
Rights | restrictedAccess |
Peer reviewed | yes |
Status | published |