Silk fibroin/chitosan pH-sensitive controlled microneedles

last updated: 2024-06-19
TitleSilk fibroin/chitosan pH-sensitive controlled microneedles
Publication TypePapers in Scientific Journals
Year of Publication2023
AuthorsJia T., Kuang D., Qi Z., Tan G., Yang X., Kundu S. C., and Lu S.
Abstract

Silk fibroin is a widely used biocompatible medical material with tunable mechanical, degradability and environmental non-toxicity. This paper prepared the silk fibroin/chitosan hydrogel microneedle with pH sensitivity by blending silk fibroin with chitosan to induce graft cross-linking. The cross-linked silk fibroin/chitosan microneedles network is expanded by hydrogen ions and water molecules, forming a more significant swelling. In vitro, the transdermal drug release showed that insulin loaded in microneedles exhibited pH-sensitive drug release behavior and was released faster under acidic conditions than under neutral conditions. By changing the pH of the solution, microneedles can achieve a stimulating response to the environment, thereby intelligently regulating the transdermal release of insulin.

JournalJournal of Materials Science
Volume58
Issue46
Pagination17711–17725
Date Published2023-12-03
PublisherSpringer
ISSN0022-2461
DOI10.1007/s10853-023-09148-1
URLhttps://link.springer.com/article/10.1007/s10853-023-09148-1#article-info
KeywordsChitosan, Fibroin microneedles, Glucose-responsive insulin, hydrogel
RightsrestrictedAccess
Peer reviewedyes
Statuspublished

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