REMOTE ACTIVATION OF ACTIVIN A TYPE II RECEPTOR VIA MAGNETIC NANOPARTICLES FOR TENDON REGENERATION STRATEGIES

last updated: 2019-01-30
ProjectRL2 – SCN :: publications list
TitleREMOTE ACTIVATION OF ACTIVIN A TYPE II RECEPTOR VIA MAGNETIC NANOPARTICLES FOR TENDON REGENERATION STRATEGIES
Publication TypeConference Abstract -ISI Web of Science Indexed
Year of Publication2018
AuthorsGonçalves A. I., Rotherham M., Markides H., Rodrigues M. T., Reis R. L., Gomes M. E., and Haj A. E.
Abstract

Tendon injuries are a worldwide problem affecting several age groups and stem cell based therapies hold potential for tendon strategies guiding tendon regeneration.

Tendons rely on mechano-sensing mechanisms that regulate homeostasis and influence regeneration. The mechanosensitive receptors available in cell membranes sense the external stimuli and initiate mechanotransduction processes. Activins are members of the TGF-β superfamily which participate in several tendon biological processes. It is envisioned that the activation of the activin receptor, trigger downstream Smad2/3 pathway thus regulating the transcription of tenogenic genes driving stem cell differentiation.
JournalOrthopaedic Proceedings
Conference NameEORS 2017
Volume100-B
IssueS4
Date Published2018-04-12
PublisherThe British Editorial Society of Bone & Joint Surgery
Conference LocationMunich
ISSN2049-4416
DOI10.1302/1358-992X.2018.4.072
URLhttps://online.boneandjoint.org.uk/doi/abs/10.1302/1358-992X.2018.4.072
KeywordsActivin receptor type IIA, TGF-β/Smad2/3 signaling pathway
RightsopenAccess
Peer reviewedyes
Statuspublished

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