Regeneration using Tissue Engineered Skin Strategies

This chapter focuses on the tissue engineering approaches that have been developed for the treatment of skin wounds with the aim of promoting cutaneous regeneration. It aims at revising and describing published work in skin tissue engineering with a focus on the most critical aspects of cutaneous wound healing, such as inflammation, re-epithelialization, matrix synthesis and remodeling, vascularization, and the generation of skin adnexal features. Tissue engineered skin substitutes are among the most promising therapeutic options for those wounds not amenable to primary closure. Along with active progress in the field, skin tissue engineering strategies have focused on exploring different tools to attain the complexity of skin tissue. Although the majority of commercialized skin tissue engineered constructs use keratinocytes and fibroblasts, a wide number of studies have included other relevant cell types such as endothelial cells.