Recreation of a hair follicle regenerative microenvironment: successes and pitfalls,

last updated: 2024-06-19
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TitleRecreation of a hair follicle regenerative microenvironment: successes and pitfalls,
Publication TypeReview Paper
Year of Publication2021
AuthorsAbreu C. M., and Marques A. P.
Abstract Text

The hair follicle (HF) is an exquisite skin appendage endowed with cyclical regenerative capacity; however, de novo follicle formation does not naturally occur. Consequently, patients suffering from extensive skin damage or hair loss are deprived of the HF critical physiological and/or aesthetic functions, severally compromising skin function and the individual's psychosocial well-being. Translation of regenerative strategies has been prevented by the loss of trichogenic capacity that relevant cell populations undergo in culture and by the lack of suitable human-based in vitro testing platforms. Here, we provide a comprehensive overview of the major difficulties associated with HF regeneration and the approaches used to overcome these drawbacks. We describe key cellular requirements and discuss the importance of the HF extracellular matrix and associated signaling for HF regeneration. Finally, we summarize the strategies proposed so far to bioengineer human HF or hair-bearing skin models and disclose future trends for the field.

JournalBioengineering & Translational Medicine
Date Published2021-05-27
Publisher John Wiley & Sons, Inc
KeywordsHair follible, hair regeneration
Peer reviewedyes

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