Protein-Based Materials as Cancer In Vitro Models

last updated: 2023-06-12
ProjectHEALTH UNORTE :: publications list
TitleProtein-Based Materials as Cancer In Vitro Models
Publication TypeBook Chapter
Year of Publication2023
AuthorsRamos P., Maia F. R., Reis R. L., and Oliveira J. M.
EditorsMaia F. R., Reis R. L., and Oliveira J. M.
Abstract Text

The extracellular matrix (ECM) plays an active role in tumor progression. Increasing evidence points out a permissive tumor microenvironment that enhances malignancy and makes drug targeting a more difficult task. Protein-based materials as a substrate for cell culture hydrogels offer the advantage of having the presence of cell-responsive sequences as opposed to synthetic polymer-based hydrogels. This is important for cancer research to evaluate different aspects of tumor proliferation, such as cell growth, cell adhesion, and cell invasion. The gold standard for protein-based hydrogels has been Matrigel. However, its ill-defined nature, low reproducibility, and weak mechanical properties do not make it an ideal scaffold for more rigorous cancer research – especially in the mechanotransduction field. Therefore, alternatives are very much in need. Herein, it is presented the main proteinaceous materials used as scaffolds to model tumor development: collagen, gelatin, fibrin, and silk fibroin.

Book Title Handbook of the Extracellular Matrix : Biologically-Derived Materials
PublisherSpringer International Publishing
ISBN 978-3-030-92090-6
KeywordsBiomaterials, Collagen, Fibrin, Gelatin, Hydrogels, in vitro models, Silk Fibroin, Tumor microenvironment
RightsembargoedAccess (2 Years)
Peer reviewedyes

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