Prospects of magnetically based approaches addressing inflammation in tendon tissues

last updated: 2024-02-01
ProjectMagTendon :: publications list
TitleProspects of magnetically based approaches addressing inflammation in tendon tissues
Publication TypeReview Paper
Year of Publication2023
AuthorsVinhas A., Almeida A. F., Rodrigues M. T., and Gomes M. E.
Abstract Text

Tendon afflictions constitute a significant share of musculoskeletal diseases and represent a primary cause of incapacity worldwide. Unresolved/chronic inflammatory states have been associated with the onset and progression of tendon disorders, contributing to undesirable immune stimulation and detri- mental tissue effects. Thus, targeting persistent inflammatory events could assist important develop- ments to solve pathophysiological processes and innovative therapeutics to address impaired healing and accomplish complete tendon regeneration.

This review overviews the impact of inflammation and inflammatory mediators in tendon niches, unveiling the importance of tendon cell populations and their signature features, and the influence of microenvironmental factors on inflamed and injured tendons. The demand for non-invasive instructive strategies to manage persistent inflammatory mediators, guide inflammatory pathways, and modulate cellular responses will also be approached by exploring the role of pulsed electromagnetic field (PEMF). PEMF alone or combined with more sophisticated systems triggered by magnetic fields will be considered in the design of successful therapies to control inflammation in tendinopathic conditions.

JournalAdvanced Drug Delivery Reviews
Volume196
Issue114815
Pagination1-15
Date Published2023-03-30
PublisherElsevier
ISSN0169-409X
DOIhttps://doi.org/10.1016/j.addr.2023.114815
KeywordsInflammatory mediators, Magnetic field Therapies, regenerative medicine, Tendinopathies, Tendon
RightsopenAccess
Peer reviewedyes
Statuspublished

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