Physicochemical features assessment of acemannan-based ternary blended films for biomedical purposes

last updated: 2021-07-02
ProjectLight2Skin :: publications list
TitlePhysicochemical features assessment of acemannan-based ternary blended films for biomedical purposes
Publication TypePapers in Scientific Journals
Year of Publication2021
AuthorsRodrigues, L.C., Fernandes E. M., Ribeiro A. R., Ribeiro A. P., Silva S. S., and Reis R. L.
EditorsCoimbra M. A., and Edgar K.

The exploitation of natural origin macromolecules, as complex physical mixtures or drugs, increases in biomedical or tissue engineering (TE) solutions. Aloe Vera is a highly explored medicinal plant, from which the main polysaccharide is acemannan (ACE). The ACE combination with chitosan and alginate results in interactions that lead to mixed junction zones formation, predicting membrane functionality improvement.

This work proposes the development and characterization of ACE-based blended films as a promising strategy to design a nature-derived bioactive platform.

The results confirmed that stable complex polyelectrolyte structures were formed through different intermolecular interactions. The films present good dimensional stability, flexibility, an adequate swelling ability with mostly radial water uptake, and a sustainable ACE release to the medium. Positive biological performance of the ACE-based blended films with L929 cells also suggested that they can be applied in TE solutions, with the potential to act as bioactive topical platforms.

JournalCarbohydrate Polymers
Date Published2021-04-01
KeywordsAcemannan, ALGINATE, Aloe vera, bioactive agents, BIOMEDICAL APPLICATIONS, Blend Films, Chitosan
Peer reviewedyes

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