Pharmacological and non-pharmacological agents versus bovine colostrum supplementation for the management of bone health using an osteoporosis-induced rat model

last updated: 2023-01-06
TitlePharmacological and non-pharmacological agents versus bovine colostrum supplementation for the management of bone health using an osteoporosis-induced rat model
Publication TypePapers in Scientific Journals
Year of Publication2022
AuthorsKydonaki, E.K., Freitas L., Reguengo, H., Raposo Simón C., Bastos A. R., Fernandes E. M., Canadas, R.F., Oliveira J. M., Correlo V. M., Reis R. L., Vliora M., Gkiata P., Koutedakis Y., Ntina G., Pinto R., Carrillo A. E., Marques F., and Amorim T.
EditorsWeaver C. M.
Abstract

Osteoporosis is defined by loss of bone mass and deteriorated bone microarchitecture. The present study compared the effects of available pharmacological and non-pharmacological agents for osteoporosis [alendronate (ALE) and concomitant supplementation of vitamin D (VD) and calcium (Ca)] with the effects of bovine colostrum (BC) supplementation in ovariectomized (OVX) and orchidectomized (ORX) rats. Seven-month-old rats were randomly allocated to: (1) placebo-control, (2) ALE group (7.5 μg/kg of body weight/day/5 times per week), (3) VD/Ca group (VD: 35 μg/kg of body weight/day/5 times per week; Ca: 13 mg/kg of body weight/day/3 times per week), and (4) BC supplementation (OVX: 1.5 g/day/5 times per week; ORX: 2 g/day/5 times per week). Following four months of supplementation, bone microarchitecture, strength and bone markers were evaluated. ALE group demonstrated significantly higher Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC and significantly lower Ct.Pr, Tb.Pr, Tb.Sp, Ct.BMD and Tb.BMD, compared to placebo (p < 0.05). BC presented significantly higher Ct.Pr, Ct.BMD, Tb.Pr, Tb.Sp, and Tb.BMD and significantly lower Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC compared to ALE in OVX rats (p < 0.05). OVX rats receiving BC experienced a significant increase in serum ALP and OC levels post-supplementation (p < 0.05). BC supplementation may induce positive effects on bone metabolism by stimulating bone formation, but appear not to be as effective as ALE.

JournalNutrients
Volume14
Edition14
Pagination2837
Date Published2022-07-11
PublisherMDPI
ISSN35889794
ISBN PMC9317446
DOI10.3390/nu14142837
Keywordsalessndronate, bovine colostrum, Calcium, Osteoporosis, vitamin D
RightsopenAccess
Peer reviewedyes
Statuspublished

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