Oxygen conditioning effect on an in vitro co-culture model of tendon-to-bone interface

last updated: 2021-02-02
ProjectMagTT :: publications list
TitleOxygen conditioning effect on an in vitro co-culture model of tendon-to-bone interface
Publication TypeConference Abstract -ISI Web of Science Indexed
Year of Publication2019
AuthorsCalejo I., Costa-Almeida R., Reis R. L., and Gomes M. E.
Abstract

Tendon-to-bone interface comprises a heterotypic cellular niche. The native interface is hypovascular, suggesting that the junction is physiologically hypoxic. As it bridges tendon and bone, which require different oxygen concentrations, a tight coordination of different oxygen concentrations along the junction must be considered when trying to mimic and understand biological events occurring within the tissue. Herein, an optimized in vitro co-culture model of tendon-derived cells (hTDCs) and pre-osteoblasts (pre-OBs) [1] was used to study the effect of a restricted oxygen environment on cell behavior.

JournalEuropean Cells & Materials Conferences
Conference NameERMIS European Chapter Meeting 2019
Date Published2019-09-01
Conference LocationRhodes, Greece
ISSN123
URLhttps://www.ecmconferences.org/abstracts/2019/Collection3/c3.html
Keywordsco-culture models, hypoxia
RightsopenAccess
Peer reviewedyes
Statuspublished

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