A novel silk fibroin bioink for 3D printing of personalized implants for musculoskeletal regeneration

Tissue engineering approaches for musculoskeletal regeneration that rely on the use of personalized implants are still pursuing the “perfect” biomimetic scaffold [1]. In these strategies, by using promising biomaterials-based inks combined with 3D printing, it is possible to control the architecture of the produced scaffolds and thus, reproduce tissue’s anatomy with a high degree of precision, resolution and reproducibility [2]. In this work, a novel fast-setting bioink based on enzymatically crosslinked silk fibroin (SF) [3] was developed for 3D printing of patient-specific implants.