Nanoparticles for Bone Tissue Engineering.

last updated: 2017-04-26
ProjectPOLARIS :: publications list
TitleNanoparticles for Bone Tissue Engineering.
Publication TypeReview Paper
Year of Publication2017
AuthorsVieira S., Vial S., Reis R. L., and Oliveira J. M.
EditorsDomach M.
Abstract Text

Tissue engineering (TE) envisions the creation of functional substitutes for damaged tissues through integrated solutions, where medical, biological, and engineering principles are combined. Bone regeneration is one of the areas in which designing a model that mimics all tissue properties is still a challenge. The hierarchical structure and high vascularization of bone hampers a TE approach, especially in large bone defects. Nanotechnology can open up a new era for TE, allowing the creation of nanostructures that are comparable in size to those appearing in natural bone. Therefore, nanoengineered systems are now able to more closely mimic the structures observed in naturally occurring systems, and it is also possible to combine several approaches - such as drug delivery and cell labeling - within a single system. This review aims to cover the most recent developments on the use of different nanoparticles for bone TE, with emphasis on their application for scaffolds improvement; drug and gene delivery carriers, and labeling techniques.

JournalBiotechnology Progress
Date Published2017-04-26
PublisherJohn Wiley & Sons
KeywordsBone Tissue Engineering, Drug and Gene Delivery, Imaging, Nanoparticles, scaffolds
Peer reviewedyes

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