Multilayered Chitosan – Alginate Hollow tubes for cardiovascular tissue engineering

last updated: 2017-05-05
ProjectMatryoshkas :: publications list
TitleMultilayered Chitosan – Alginate Hollow tubes for cardiovascular tissue engineering
Publication TypeComunications - Poster
Year of Publication2014
AuthorsSilva J. M., Duarte A. R. C., Reis R. L., and Mano J. F.

In this work we develop a method for the preparation of nanostructured hollow multilayered tubes combining layer-by-layer (LbL) technique and template leaching. The use of layer by layer techniques allows the production of nanometer-sized polymer films of particular interest for tissue engineering and regenerative medicine as they allow a precise control of physical and biological cues as well as the recreation of the natural complexity of ECM. Our aim was to produce hollow tubes for cardiovascular tissue engineering applications. Tubes of chitosan and alginate were prepared with or without crosslinking and their physic- chemical characterization was performed using different techniques. The permeability of the membranes towards glucose and oxygen was evaluated. We further evaluate the biological performance in terms of cell adhesion, viability and proliferation. The results suggested the potential of these structures to boost the development of innovative tubular structures for tissue engineering approaches. 

Conference NameSociety for Biomaterials 2014 Annual Meeting and Exposition: Pioneering the Future of Biomaterials,
Date Published2014-04-16
Conference LocationDenver
Keywordscardiovascular, layer-by-layer assembling, Multilayered films
Peer reviewedno

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