Project | EPIDisc :: publications list |
Title | Materials for cell delivery in degenerated intervertebral disc |
Publication Type | Book Chapter |
Year of Publication | 2018 |
Authors | Silva-Correia J., Oliveira J. M., and Reis R. L. |
Editors | Gonçalves R. M., and Barbosa M. A. |
Abstract Text | Several polymers have been investigated as potential cell delivery carriers for intervertebral disc (IVD) regeneration, which can be divided into natural and synthetic biopolymers and can be used in the form of hydrogels or solid scaffolds. Biomaterials provide a stable threedimensional (3D) environment for cell proliferation and extracellular matrix (ECM) synthesis, by serving as a load bearing structure to support IVD biomechanical forces. Ideally, it should degrade in parallel with neo-tissue formation, without forming toxic subproducts. Also, biomaterials enable better reproduction of the native tissue by providing clearly defined microstructures and macrostructures. Although some approaches to IVD regeneration consider the use of |
Book Title | Gene and Cell Delivery for Intervertebral Disc Degeneration |
Pagination | 137-153 |
Date | 2018-04-30 |
Publisher | Taylor & Francis Group |
ISBN | 978-1-4987-9940-9 |
DOI | 10.1201/9781351030182 |
URL | https://www.crcpress.com/Gene-and-Cell-Delivery-for-Invertebral-Disc-Degeneration/Goncalves-Barbosa/p/book/9781498799409 |
Keywords | intervertebral disc, materials |
Rights | restrictedAccess |
Peer reviewed | yes |
Status | published |