Kefiran cryogels as potential scaffolds for drug delivery and tissue engineering applications
last updated: 2020-08-06
| Project | KOAT :: publications list |
| Title | Kefiran cryogels as potential scaffolds for drug delivery and tissue engineering applications |
| Publication Type | Papers in Scientific Journals |
| Year of Publication | 2019 |
| Authors | Radhouani H., Bicho D., Gonçalves C., Maia F. R., Reis R. L., and Oliveira J. M. |
| Editors | De Geuser F., Giebeler L., Humphry-Baker S., Martin T., and Miquelard-Garnier G. |
| Abstract | A Kefiran-based scaffold was developed using a freeze gelation technique, and its potential use for both drug delivery system and tissue engineering applications were investigated. This scaffold showed, through micro-computed tomography and scanning electron microscopy, high porosity (82.3 ± 4.4%), thick pore walls (13.4 ± 0.7 μm), aerogel form with foam-like structure, and elastic behaviour (δ = 16 ± 0.7º). Moreover, the Kefiran scaffold degradation showed a delayed profile for over 28 days. The developed scaffold allowed a slow and sustained diclofenac release over two weeks, and the human Adipose-derived Stem Cells, cultured onto the Kefiran scaffold, were metabolically active after 72 h. Therefore, our research suggests that Kefiran cryogel could be a potential candidate for drug delivery of controlled bioactive molecules and tissue engineering scaffolding.
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| Journal | Materials Today Communications |
| Pagination | 100554 |
| Date Published | 2019-06-25 |
| Publisher | Elsevier |
| ISSN | 2352-4928 |
| DOI | 10.1016/j.mtcomm.2019.100554 |
| URL | https://www.sciencedirect.com/science/article/pii/S2352492818303064#abs0015 |
| Keywords | diclofenac, Drug Delivery System, Kefiran cryogels, scaffolds, Tissue engineering |
| Rights | closedAccess |
| Peer reviewed | yes |
| Status | published |
